Erythromycin (cas 114-07-8) Molecular Structure

CAS No. 114-07-8 (Erythromycin )

Molecular Formula: C37H67NO13Molecular Weight: 733.92678

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References of Erythromycin cas 114-07-8

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 10mg/kg/1D-I (10mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Annals of Internal Medicine. Vol. 115, Pg. 69, 1991.
child TDLo oral 250mg/kg (250mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: OTHER CHANGES

BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT
Pediatrics. Vol. 90, Pg. 624, 1992.
dog LDLo unreported > 100mg/kg (100mg/kg) ? Antibiotics and Chemotherapy Vol. 2, Pg. 281, 1952.
guinea pig LD50 intraperitoneal 413mg/kg (413mg/kg) ? Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 41, Pg. 555, 1952.
hamster LD50 oral 3018mg/kg (3018mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 41, Pg. 555, 1952.
mouse LD50 intramuscular 394mg/kg (394mg/kg) ? Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 44, Pg. 199, 1955.
mouse LD50 intraperitoneal 280mg/kg (280mg/kg) ? Journal of Antibiotics. Vol. 43, Pg. 938, 1990.
mouse LD50 intravenous 426mg/kg (426mg/kg) ? "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 273, 1967.
mouse LD50 oral 2580mg/kg (2580mg/kg) ? Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 31, Pg. 241, 1974.
mouse LD50 subcutaneous 1800mg/kg (1800mg/kg) ? Antibiotics and Chemotherapy Vol. 2, Pg. 281, 1952.
rat LD50 oral 4600mg/kg (4600mg/kg) ? Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 31, Pg. 241, 1974.
rat LDLo subcutaneous 427mg/kg (427mg/kg) ? Compilation of LD50 Values of New Drugs.

Safety

Poison by intravenous and intramuscular routes. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:?HarmfulXn,IrritantXi
Risk Statements: 42/43-36/37/38?
R42/43:May cause sensitization by inhalation and skin contact.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 45-37-24-36-26?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S37:Wear suitable gloves.?
S24:Avoid contact with skin.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
WGK Germany: 2
RTECS of Erythromycin (CAS NO.114-07-8): KF4375000