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Home> CAS DataBase Listed 1 > CAS 122111-03-9
Identification of 122111-03-9
  • Name:
  • Gemcitabine hydrochloride (Related Reference)
  • Synonyms:
  • Gemcitabine HCl; 2',2'-Difluorodeoxycytidine monohydrochloride; 2'-Deoxy-2',2'-difluorocytidine monohydrochloride; 2'-Deoxy-2',2'-difluorocytidine monohydrochloride (beta-isomer);
  • InChI:
  • InChI=1/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
  • This structure is also available as a 2d Mol file
Safety Data of 122111-03-9 Properties of 122111-03-9
  • Appearance:
  • White crystalline granular, odorless
  • Molecular Weight:
  • 299.66
  • Density:
  • ==
  • Boiling Point:
  • 482.7 °C at 760 mmHg
  • Melting Point:
  • >250°C dec
  • Flash Point:
  • 245.7 °C
  • Solubility:
  • In water, 5.13X10+4 mg/L at 25 deg C (est)
  • Biological Activity:
  • Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo .
  • Usage:
  • An antineoplastic

  • More>>

CAS No. 122111-03-9 (Gemcitabine hydrochloride )

  • CAS No:122111-03-9
  • Molecular Weight: 299.66
  • Molecular Formula: C9H11F2N3O4.HCl
Properties Safety and Handling MSDS NMR Spectrum Synthesis Route Precursor and Product
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Precursor and Product
References of Gemcitabine hydrochloride cas 122111-03-9

Toxicity

?

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 500mg/kg (500mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 391, 2000.
rat LD50 intravenous 236mg/kg (236mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 391, 2000.
women TDLo parenteral 300mg/kg/12W- (300mg/kg) LUNGS, THORAX, OR RESPIRATION: CONSOLIDATION

LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Cancer Vol. 80, Pg. 286, 1997.

Safety

Hazard Codes:?HarmfulXn,Xi
Risk Statements: 21-36/38-46-62-63
R21: Harmful in contact with skin.
R36/38: Irritating to eyes and skin.?
R46: May cause heritable genetic damage.?
R62: Risk of impaired fertility.?
R63: Possible risk of harm to the unborn child.
Safety Statements: 25-26-36/37-53
S25: Avoid contact with eyes.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37: Wear suitable protective clothing and gloves.?
S53: Avoid exposure - obtain special instructions before use.
Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx, HCl, and F?.

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