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Home> CAS DataBase Listed 1 > CAS 123-91-1
Identification of 123-91-1 Safety Data of 123-91-1 Properties of 123-91-1
  • Appearance:
  • Colorless clear liquid
  • Molecular Weight:
  • 88.11
  • Density:
  • 1.033
  • Boiling Point:
  • 101℃
  • Melting Point:
  • 12℃
  • Flash Point:
  • 12℃
  • Storage Temperature:
  • Flammables area
  • Refractive index:
  • 1.4205-1.422
  • Solubility:
  • Soluble in water
  • Stability:
  • Stable. Incompatible with oxidizing agents, oxygen, halogens, reducing agents, moisture. Highly flammable - note wide explosive range. May form explosive peroxides in storage (rate of formation increased by heating, evaporation or exposure to light).
  • More>>

CAS No. 123-91-1 (1,4-Dioxane )

  • CAS No:123-91-1
  • Molecular Weight: 88.11
  • Molecular Formula: C4H8O2
Properties Safety and Handling MSDS NMR Spectrum Precursor and Product
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Precursor and Product
References of 1,4-Dioxane cas 123-91-1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LCLo inhalation 44gm/m3/7H (44000mg/m3) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
"Beitrag zur Toxikologischen Wirkung Technischer Losungsmittel, Dissertation," Klimmer, O., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1937Vol. -, Pg. -, 1937.
cat LD50 oral 2gm/kg (2000mg/kg) ? Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.
cat LDLo intravenous 1500mg/kg (1500mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: IRRITABILITY
Journal of Hygiene. Vol. 35, Pg. 540, 1935.
guinea pig LD50 oral 3150mg/kg (3150mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

GASTROINTESTINAL: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
human LCLo inhalation 470ppm/3D (470ppm) BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LIVER: OTHER CHANGES
Pollution Engineering. Vol. 7(9), Pg. 22, 1975.
human TCLo inhalation 470ppm (470ppm) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION

GASTROINTESTINAL: OTHER CHANGES
AMA Archives of Industrial Health. Vol. 20, Pg. 445, 1959.
human TCLo inhalation 5500ppm/1M (5500ppm) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Public Health Reports. Vol. 45, Pg. 2023, 1930.
mammal (species unspecified) LC50 inhalation 20500mg/m3 (20500mg/m3) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(5), Pg. 61, 1986.
mouse LC50 inhalation 37gm/m3/2H (37000mg/m3) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 63, 1982.
mouse LD50 intraperitoneal 790mg/kg (790mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.
mouse LD50 oral 5300mg/kg (5300mg/kg) ? Indian Journal of Experimental Biology. Vol. 16, Pg. 54, 1978.
rabbit LD50 oral 2gm/kg (2000mg/kg) ? Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.
rabbit LD50 skin 7600uL/kg (7.6mL/kg) ? Union Carbide Data Sheet. Vol. 12/17/1971,
rabbit LDLo intravenous 1500mg/kg (1500mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Journal of Hygiene. Vol. 35, Pg. 540, 1935.
rat LC50 inhalation 46gm/m3/2H (46000mg/m3) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Kosmicheskaya Biologiya I Aviakosmicheskaya Meditsina. Space Biology and Aerospace Medicine. Vol. 11(6), Pg. 53, 1977.
rat LD50 intraperitoneal 799mg/kg (799mg/kg) ? Environmental Research. Vol. 40, Pg. 411, 1986.
rat LD50 oral 4200mg/kg (4200mg/kg) ? Industrial Health. Vol. 32, Pg. 145, 1994.

Safety

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion and inhalation. Mildly toxic by skin contact. Human systemic effects by inhalation: lachrymation, conjunctiva irritation, convulsions, high blood pressure, unspecified respiratory and gastrointestinal system effects. Mutation data reported. An eye and skin irritant. The irritant effects probably provide sufficient warning, in acute exposures, to enable a worker to leave exposure before being seriously affected. Repeated exposure to low concentrations has resulted in human fatalities, the organs chiefly affected being the liver and kidneys.
A very dangerous fire and explosion hazard when exposed to heat or flame; can react vigorously with oxidizing materials. Violent reaction with (H2 + Raney Ni), AgClO4. Can form dangerous peroxides when exposed to air. Potentially explosive reaction with nitric acid + perchloric acid, Raney nickel catalyst (above 210°C). Forms explosive mixtures with decaborane (impact-sensitive), triethynylaluminum (sensitive to heating or drying). Violent reaction with sulfur trioxide. Incompatible with sulfur trioxide. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also GLYCOL ETHERS.
The Hazard Codes of? ?: ?Xn,?? F,? T
The Risk Statements information of?Dioxane (CAS NO.123-91-1):
11:? Highly Flammable?
19:? May form explosive peroxides?
40:? Limited evidence of a carcinogenic effect?
41:? Risk of serious damage to eyes?
45:? May cause cancer?
46:? May cause heritable genetic damage?
36/37/38:? Irritating to eyes, respiratory system and skin?
39/23/24/25:? Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed?
48/20/22:? Harmful: danger of serious damage to health by prolonged exposure through inhalation and if swallowed?
The Safety Statements information:
7:? Keep container tightly closed?
9:? Keep container in a well-ventilated place?
16:? Keep away from sources of ignition - No smoking?
23:? Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)?
26:? In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
45:? In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)?
46:? If swallowed, seek medical advice immediately and show this container or label?
53:? Avoid exposure - obtain special instruction before use?
62:? If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label
24/25:? Avoid contact with skin and eyes?
36/37:? Wear suitable protective clothing and gloves?
RIDADR?: UN 1993 3/PG 2
WGK Germany:? 3

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