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Home> CAS DataBase Listed 1 > CAS 123318-82-1
Identification of 123318-82-1
  • Name:
  • Clofarabine (Related Reference)
  • Synonyms:
  • C1-F-Ara-A; 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-; 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine; Clofarabine, 5-(6-Amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol; 5-(6-Amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol; Clofarex; Clolar; 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine; (2R,3R,4S,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol; CAFDA; 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-; Clofarabine(Clofarabine or called Keluola foreshore); 2-Chloro-6-amino-purine-2'-fluoro-2'- deoxy arabineoside;
  • InChI:
  • InChI=1/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
  • This structure is also available as a 2d Mol file
Safety Data of 123318-82-1 Properties of 123318-82-1
  • Appearance:
  • White Solid
  • Molecular Weight:
  • 303.68
  • Density:
  • 2.12 g/cm3
  • Boiling Point:
  • 550 °C at 760 mmHg
  • Melting Point:
  • 228-2310C
  • Flash Point:
  • 286.4 °C
  • Refractive index:
  • 1.843
  • Biological Activity:
  • Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase- α and - ε and potently inhibits ribonucleotide reductase (IC 50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.
  • Usage:
  • ISecond generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic
  • More>>

CAS No. 123318-82-1 (Clofarabine )

  • CAS No:123318-82-1
  • Molecular Weight: 303.68
  • Molecular Formula: C10H11ClFN5O3
Properties Safety and Handling MSDS NMR Spectrum Precursor and Product
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Precursor and Product
References of Clofarabine cas 123318-82-1

Usage and Possible Side Effects of Clofarabine(CAS No. 123318-82-1)

Clofarabine(CAS No. 123318-82-1) belongs to the group of medicines known as antineoplastics. It is used to treat a type of cancer of the white blood cells called acute lymphoblastic leukemia (ALL) in patients 1 to 21 years of age who have already used at least two other cancer medicines. 

 

Clofarabine interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells also may be affected by clofarabine, other effects also occur. Some of these effects may be serious and must be reported to your doctor.

 

Before you begin treatment with clofarabine(CAS NO.123318-82-1), you and your doctor should talk about the good this medicine will do as well as the risks of using it. It is to be administered only by or under the immediate supervision of your doctor. So let me show you how it is given and what possible side effects it may have?

 

How Clofarabine(CAS NO.123318-82-1) is given?

 

Clofarabine(CAS NO.123318-82-1) is given as a drip (infusion) that usually takes about two hours. It's given in one of the following ways:

1.through a fine tube inserted into a vein, usually in the back of the hand (cannula).

2.through a fine, plastic tube inserted under the skin and into a vein near the collarbone (central line).

3.into a fine tube inserted into a vein in the crook of the arm (PICC line).

4.into a small port placed under the skin below the collarbone (Implantable ports).

 

Your doctor or specialist nurse will explain more about how it is given to you. Chemotherapy is usually given as a course of several sessions (or cycles) of treatment over a few months. Clofarabine(CAS NO.123318-82-1) is usually given every day for five days, and repeated every 2-6 weeks. The nurse or doctor will discuss your treatment plan with you and your child. Before your child begins treatment, their doctor will arrange for them to have blood tests. They will usually be given anti-sickness drugs before and/or during their treatment.

 

Possible side effects of Clofarabine(CAS NO.123318-82-1)

1.Tumor lysis syndrome (TLS). Clofarabine(CAS NO.123318-82-1) quickly kills leukaemia cells in the blood. The body may react to this. Signs include hyperkalemia, hyperuricemia, and hyperphosphatemia. TLS is very serious and can lead to death if it is not treated right away.

2.Systemic Inflammatory Response Syndrome (SIRS): Symptoms include fast breathing, fast heartbeat, low blood pressure, and fluid in the lungs.

3.Bone marrow problems (suppression). Clofarabine can stop the bone marrow from making enough red blood cells, white blood cells, and platelets. Serious side effects that can happen because of bone marrow suppression include severe infection (sepsis), bleeding, and anemia. Effects on pregnancy and breastfeeding. Girls and women should not become pregnant or breastfeed during treatment which may harm the baby.

4.Dehydration and low blood pressure. Clofarabine(CAS NO.123318-82-1) can cause vomiting and diarrhea which may lead to low body fluid (dehydration). Signs and symptoms of dehydration include dizziness, lightheadedness, fainting spells, or decreased urination.

5.Other side effects. The most common side effects are stomach problems (including vomiting, diarrhea, and nausea), and effects on blood cells (including low red blood cells count, low white blood cell count, low platelet count, fever, and infection. Clofarabine can also cause tachycardia and can affect the liver and kidneys.