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Home> CAS DataBase Listed 1 > CAS 124750-99-8
Identification of 124750-99-8
  • Name:
  • Losartan potassium (Related Reference)
  • Synonyms:
  • Lotim; L-158086; Ocsaar; Losacor; Tenopres; Lortaan; Losaprex; Hyzaar; Niten; DuP 753; Losartan monopotassium salt; MK 954; Lorzaan; Cozaar; Llosartan; Losartanpotassium; Lorzaar; 1H-Imidazole-5-methanol,2-butyl-4-chloro- 1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]- methyl]-,monopotassium salt; 2-Butyl-4-chloro-1-(2-(tetrazol-5-yl)biphenyl-4-ylmethyl)-1H-imidazole-5-methanol potassium; MK-0954; Losacar; MK 0954; potassium [2-butyl-5-chloro-3-[[4-[2-(2,3,4-triaza-1-azanidacyclopenta-2,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol; Cozaar (TN);
  • InChI:
  • InChI=1/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
  • This structure is also available as a 2d Mol file
Safety Data of 124750-99-8 Properties of 124750-99-8
  • Appearance:
  • white to off-white crystalline powder
  • Molecular Weight:
  • 461.01
  • Boiling Point:
  • 682 °C at 760mmHg
  • Melting Point:
  • 183.5-184.5 deg C /Losartan/
  • Flash Point:
  • 366.3 °C
  • Solubility:
  • Freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone.
  • Biological Activity:
  • Selective non-peptide angiotensin AT 1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA 2 = 8.27). Orally active antihypertensive agent.
  • Usage:
  •  Losartan potassium (CAS NO.124750-99-8) can be used as a nonpeptide angiotensin II AT1-receptor antagonist.

  • More>>

CAS No. 124750-99-8 (Losartan potassium )

  • CAS No:124750-99-8
  • Molecular Weight: 461.01
  • Molecular Formula: C22H22ClKN6OK
Properties Safety and Handling MSDS NMR Spectrum Synthesis Route Precursor and Product
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Precursor and Product
References of Losartan potassium cas 124750-99-8

Toxicity

dog LD oral > 320mg/kg (320mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
man TDLo oral 10mg/kg/2W-I (10mg/kg) BLOOD: HEMORRHAGE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Archives of Internal Medicine. Vol. 158, Pg. 191, 1998.
mouse LDLo intraperitoneal 400mg/kg (400mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
mouse LDLo oral 1gm/kg (1000mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
rat LDLo intraperitoneal 200mg/kg (200mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
rat LDLo oral 2gm/kg (2000mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3959, 1994.
women TDLo oral 1mg/kg/1D-I (1mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" Archives of Internal Medicine. Vol. 158, Pg. 2063, 1998.

Safety

Hazard Codes:?IrritantXi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RTECS: NI6755100

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