minocycline hydrochloride (cas 13614-98-7) Molecular Structure

CAS No. 13614-98-7 (minocycline hydrochloride )

Molecular Formula: C23H27N3O7?HClMolecular Weight: 493.94

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References of minocycline hydrochloride cas 13614-98-7

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 14286ug/kg/10 (14.286mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Archives of Internal Medicine. Vol. 154, Pg. 1633, 1994.
man TDLo intravenous 2857ug/kg (2.857mg/kg) LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Internal Medicine. Vol. 33, Pg. 177, 1994.
man TDLo oral 11429ug/kg/4D (11.429mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Archives of Dermatology. Vol. 123, Pg. 18, 1987.
man TDLo oral 3893mg/kg/4Y- (3893mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Archives of Dermatology. Vol. 122, Pg. 17, 1986.
mouse LD50 intraperitoneal 299mg/kg (299mg/kg) ? Drugs in Japan Vol. 6, Pg. 811, 1982.
mouse LD50 intravenous 154mg/kg (154mg/kg) ? Drugs in Japan Vol. 6, Pg. 811, 1982.
mouse LD50 oral 3600mg/kg (3600mg/kg) ? Drugs in Japan Vol. 6, Pg. 811, 1982.
mouse LD50 subcutaneous 2290mg/kg (2290mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990.
mouse LDLo parenteral 620mg/kg (620mg/kg) ? Chemotherapy Vol. 24, Pg. 17, 1978.
rat LD50 intraperitoneal 331mg/kg (331mg/kg) ? Drugs in Japan Vol. 6, Pg. 811, 1982.
rat LD50 intravenous 164mg/kg (164mg/kg) ? Drugs in Japan Vol. 6, Pg. 811, 1982.
rat LD50 oral 2380mg/kg (2380mg/kg) ? Drugs in Japan Vol. 6, Pg. 811, 1982.
rat LD50 subcutaneous 1700mg/kg (1700mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990.
women TDLo oral 42mg/kg/3W-I (42mg/kg) BLOOD: AGRANULOCYTOSIS
BLOOD: OTHER CHANGES
MUSCULOSKELETAL: JOINTS
Archives of Internal Medicine. Vol. 154, Pg. 1983, 1994.

Safety

Hazard Codes:?IrritantXi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
RIDADR: 3249
WGK Germany: 3
RTECS: QI7630500
HazardClass: 6.1(b)
PackingGroup:? III
Risk Statements:?Irritating to the eyes;Irritating to the respiratory system;Irritating to the skin
Safety Statements:?Wear suitable protective clothing
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and parenteral routes. Human systemic effects: dermatitis, eye effects, increased body temperature. When heated to decomposition it emits toxic fumes of NOx and HCl.