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Home> CAS DataBase Listed 1 > CAS 13614-98-7
Identification of 13614-98-7
  • Name:
  • minocycline hydrochloride (Related Reference)
  • EINECS:
  • 237-099-7
  • Synonyms:
  • Minocycline HCL; Minocyclin HCl; (4s-(4alpha,4aalpha,5aalpha,12aalpha))-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride
  • InChI:
  • InChI=1/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
  • This structure is also available as a 2d Mol file
Safety Data of 13614-98-7 Properties of 13614-98-7
  • Appearance:
  • crystalline yellow
  • Molecular Weight:
  • 493.94
  • Boiling Point:
  • 659.4°Cat760mmHg
  • Melting Point:
  • 205-210ºC(dec)
  • Flash Point:
  • 352.6°C
  • Storage Temperature:
  • 2-8°C
  • Usage:

  • Second generation tetracycline antibiotic. Antibacterial.

  • More>>

CAS No. 13614-98-7 (minocycline hydrochloride )
  • CAS No:13614-98-7
  • Molecular Weight: 493.94
  • Molecular Formula: C23H27N3O7?HCl
Properties Safety and Handling MSDS
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References of minocycline hydrochloride cas 13614-98-7

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 14286ug/kg/10 (14.286mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 Archives of Internal Medicine. Vol. 154, Pg. 1633, 1994.
man TDLo intravenous 2857ug/kg (2.857mg/kg) LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Internal Medicine. Vol. 33, Pg. 177, 1994.
man TDLo oral 11429ug/kg/4D (11.429mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 Archives of Dermatology. Vol. 123, Pg. 18, 1987.
man TDLo oral 3893mg/kg/4Y- (3893mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Archives of Dermatology. Vol. 122, Pg. 17, 1986.
mouse LD50 intraperitoneal 299mg/kg (299mg/kg) ? Drugs in Japan Vol. 6, Pg. 811, 1982.
mouse LD50 intravenous 154mg/kg (154mg/kg) ? Drugs in Japan Vol. 6, Pg. 811, 1982.
mouse LD50 oral 3600mg/kg (3600mg/kg) ? Drugs in Japan Vol. 6, Pg. 811, 1982.
mouse LD50 subcutaneous 2290mg/kg (2290mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990.
mouse LDLo parenteral 620mg/kg (620mg/kg) ? Chemotherapy Vol. 24, Pg. 17, 1978.
rat LD50 intraperitoneal 331mg/kg (331mg/kg) ? Drugs in Japan Vol. 6, Pg. 811, 1982.
rat LD50 intravenous 164mg/kg (164mg/kg) ? Drugs in Japan Vol. 6, Pg. 811, 1982.
rat LD50 oral 2380mg/kg (2380mg/kg) ? Drugs in Japan Vol. 6, Pg. 811, 1982.
rat LD50 subcutaneous 1700mg/kg (1700mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990.
women TDLo oral 42mg/kg/3W-I (42mg/kg) BLOOD: AGRANULOCYTOSIS
BLOOD: OTHER CHANGES
MUSCULOSKELETAL: JOINTS		 Archives of Internal Medicine. Vol. 154, Pg. 1983, 1994.

Safety

Hazard Codes:?IrritantXi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
RIDADR: 3249
WGK Germany: 3
RTECS: QI7630500
HazardClass: 6.1(b)
PackingGroup：? III
Risk Statements：?Irritating to the eyes；Irritating to the respiratory system；Irritating to the skin
Safety Statements：?Wear suitable protective clothing
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and parenteral routes. Human systemic effects: dermatitis, eye effects, increased body temperature. When heated to decomposition it emits toxic fumes of NOx and HCl.

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