CAS No. 13614-98-7 (minocycline hydrochloride )
Molecular Formula: C23H27N3O7?HClMolecular Weight: 493.94
Identification of 13614-98-7
- Name:
- minocycline hydrochloride (Related Reference)
- EINECS:
- 237-099-7
- Molecular Formula:
- C23H27N3O7?HCl
- CAS Registry Number:
- 13614-98-7
- Synonyms:
- Minocycline HCL; Minocyclin HCl; (4s-(4alpha,4aalpha,5aalpha,12aalpha))-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride
- InChI:
- InChI=1/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
- Molecular Structure:
- This structure is also available as a 2d Mol file
Chemical Properties
- Appearance:
- crystalline yellow
- Molecular Weight:
- 493.94
- Boiling Point:
- 659.4°Cat760mmHg
- Melting Point:
- 205-210ºC(dec)
- Flash Point:
- 352.6°C
- Storage Temperature:
- 2-8°C
- Usage:
Second generation tetracycline antibiotic. Antibacterial.
Safety Data of 13614-98-7
- Risk Codes:
- R36/37/38
- Safety Statements:
- S26;S36
- Hazard Symbols:
-
Xi:Irritant
HazardClass:6.1(b)
- MSDS infomation:
- minocycline hydrochloride (13614-98-7).msds
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References of minocycline hydrochloride cas 13614-98-7
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TDLo | oral | 14286ug/kg/10 (14.286mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Archives of Internal Medicine. Vol. 154, Pg. 1633, 1994. |
| man | TDLo | intravenous | 2857ug/kg (2.857mg/kg) | LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Internal Medicine. Vol. 33, Pg. 177, 1994. |
| man | TDLo | oral | 11429ug/kg/4D (11.429mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Archives of Dermatology. Vol. 123, Pg. 18, 1987. |
| man | TDLo | oral | 3893mg/kg/4Y- (3893mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Archives of Dermatology. Vol. 122, Pg. 17, 1986. |
| mouse | LD50 | intraperitoneal | 299mg/kg (299mg/kg) | ? | Drugs in Japan Vol. 6, Pg. 811, 1982. |
| mouse | LD50 | intravenous | 154mg/kg (154mg/kg) | ? | Drugs in Japan Vol. 6, Pg. 811, 1982. |
| mouse | LD50 | oral | 3600mg/kg (3600mg/kg) | ? | Drugs in Japan Vol. 6, Pg. 811, 1982. |
| mouse | LD50 | subcutaneous | 2290mg/kg (2290mg/kg) | ? | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990. |
| mouse | LDLo | parenteral | 620mg/kg (620mg/kg) | ? | Chemotherapy Vol. 24, Pg. 17, 1978. |
| rat | LD50 | intraperitoneal | 331mg/kg (331mg/kg) | ? | Drugs in Japan Vol. 6, Pg. 811, 1982. |
| rat | LD50 | intravenous | 164mg/kg (164mg/kg) | ? | Drugs in Japan Vol. 6, Pg. 811, 1982. |
| rat | LD50 | oral | 2380mg/kg (2380mg/kg) | ? | Drugs in Japan Vol. 6, Pg. 811, 1982. |
| rat | LD50 | subcutaneous | 1700mg/kg (1700mg/kg) | ? | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990. |
| women | TDLo | oral | 42mg/kg/3W-I (42mg/kg) | BLOOD: AGRANULOCYTOSIS BLOOD: OTHER CHANGES MUSCULOSKELETAL: JOINTS |
Archives of Internal Medicine. Vol. 154, Pg. 1983, 1994. |
Hazard Codes:?Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
RIDADR: 3249
WGK Germany: 3
RTECS: QI7630500
HazardClass: 6.1(b)
PackingGroup：? III
Risk Statements：?Irritating to the eyes；Irritating to the respiratory system；Irritating to the skin
Safety Statements：?Wear suitable protective clothing
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and parenteral routes. Human systemic effects: dermatitis, eye effects, increased body temperature. When heated to decomposition it emits toxic fumes of NOx and HCl.
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