
CAS No. 13614-98-7 (minocycline hydrochloride )
Molecular Formula: C23H27N3O7?HClMolecular Weight: 493.94
Identification of 13614-98-7
- Name:
- minocycline hydrochloride (Related Reference)
- EINECS:
- 237-099-7
- Molecular Formula:
- C23H27N3O7?HCl
- CAS Registry Number:
- 13614-98-7
- Synonyms:
- Minocycline HCL; Minocyclin HCl; (4s-(4alpha,4aalpha,5aalpha,12aalpha))-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride
- InChI:
- InChI=1/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
- Molecular Structure:
- This structure is also available as a 2d Mol file
Chemical Properties
- Appearance:
- crystalline yellow
- Molecular Weight:
- 493.94
- Boiling Point:
- 659.4°Cat760mmHg
- Melting Point:
- 205-210ºC(dec)
- Flash Point:
- 352.6°C
- Storage Temperature:
- 2-8°C
- Usage:
Second generation tetracycline antibiotic. Antibacterial.
Safety Data of 13614-98-7
- Risk Codes:
- R36/37/38
- Safety Statements:
- S26;S36
- Hazard Symbols:
-
Xi:Irritant
HazardClass:6.1(b)
- MSDS infomation:
- minocycline hydrochloride (13614-98-7).msds
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References of minocycline hydrochloride cas 13614-98-7
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
human | TDLo | oral | 14286ug/kg/10 (14.286mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Archives of Internal Medicine. Vol. 154, Pg. 1633, 1994. |
man | TDLo | intravenous | 2857ug/kg (2.857mg/kg) | LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Internal Medicine. Vol. 33, Pg. 177, 1994. |
man | TDLo | oral | 11429ug/kg/4D (11.429mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Archives of Dermatology. Vol. 123, Pg. 18, 1987. |
man | TDLo | oral | 3893mg/kg/4Y- (3893mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Archives of Dermatology. Vol. 122, Pg. 17, 1986. |
mouse | LD50 | intraperitoneal | 299mg/kg (299mg/kg) | ? | Drugs in Japan Vol. 6, Pg. 811, 1982. |
mouse | LD50 | intravenous | 154mg/kg (154mg/kg) | ? | Drugs in Japan Vol. 6, Pg. 811, 1982. |
mouse | LD50 | oral | 3600mg/kg (3600mg/kg) | ? | Drugs in Japan Vol. 6, Pg. 811, 1982. |
mouse | LD50 | subcutaneous | 2290mg/kg (2290mg/kg) | ? | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990. |
mouse | LDLo | parenteral | 620mg/kg (620mg/kg) | ? | Chemotherapy Vol. 24, Pg. 17, 1978. |
rat | LD50 | intraperitoneal | 331mg/kg (331mg/kg) | ? | Drugs in Japan Vol. 6, Pg. 811, 1982. |
rat | LD50 | intravenous | 164mg/kg (164mg/kg) | ? | Drugs in Japan Vol. 6, Pg. 811, 1982. |
rat | LD50 | oral | 2380mg/kg (2380mg/kg) | ? | Drugs in Japan Vol. 6, Pg. 811, 1982. |
rat | LD50 | subcutaneous | 1700mg/kg (1700mg/kg) | ? | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990. |
women | TDLo | oral | 42mg/kg/3W-I (42mg/kg) | BLOOD: AGRANULOCYTOSIS BLOOD: OTHER CHANGES MUSCULOSKELETAL: JOINTS |
Archives of Internal Medicine. Vol. 154, Pg. 1983, 1994. |
Hazard Codes:?Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
RIDADR: 3249
WGK Germany: 3
RTECS: QI7630500
HazardClass: 6.1(b)
PackingGroup:? III
Risk Statements:?Irritating to the eyes;Irritating to the respiratory system;Irritating to the skin
Safety Statements:?Wear suitable protective clothing
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and parenteral routes. Human systemic effects: dermatitis, eye effects, increased body temperature. When heated to decomposition it emits toxic fumes of NOx and HCl.