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Home> CAS DataBase Listed 1 > CAS 143-67-9
Identification of 143-67-9
  • Name:
  • Vinblastine sulfate (Related Reference)
  • EINECS:
  • 205-606-0
  • Synonyms:
  • Alkaban-AQ; Exal; VLBmonosulfate; Velban; Velbe; Velsar; Vincaleukoblastine derivative; vincaleukoblastine, (2'beta)-; (2'beta)-Vincaleukoblastine; Vincaleukoblastine sulfate (1:1) (salt); Vinblastine 5; Rozevin sulfate;
  • InChI:
  • InChI=1/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
  • This structure is also available as a 2d Mol file
Safety Data of 143-67-9 Properties of 143-67-9
  • Appearance:
  • white powder
  • Molecular Weight:
  • 909.06
  • Density:
  • 1.37 g/cm3
  • Melting Point:
  • 267℃
  • Alpha:
  • -21.7 o (C=2, CH3OH 21 oC)
  • Storage Temperature:
  • 2-8°C
  • Solubility:
  • H2O: 10 mg/mL
  • Biological Activity:
  • Anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells.
  • Stability:
  • No data.
  • Usage:
  • An antineoplastic

  • More>>

CAS No. 143-67-9 (Vinblastine sulfate )

  • CAS No:143-67-9
  • Molecular Weight: 909.06
  • Molecular Formula: C46H58N4O9
Properties Safety and Handling MSDS
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References of Vinblastine sulfate cas 143-67-9

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 500ug/kg (0.5mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3713-83,
hamster LD50 intraperitoneal 4300ug/kg (4.3mg/kg) ? Cancer Letters Vol. 2, Pg. 267, 1977.
human TDLo intravenous 557ug/kg (0.557mg/kg) BLOOD: LEUKOPENIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Cancer Chemotherapy Reports. Vol. 29, Pg. 111, 1963.
mouse LD50 intraperitoneal 2700ug/kg (2.7mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.
mouse LD50 intravenous 9500ug/kg (9.5mg/kg) ? Cancer Research. Vol. 39, Pg. 3575, 1979.
mouse LD50 oral 423mg/kg (423mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
mouse LD50 subcutaneous 324mg/kg (324mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
rat LD50 intraperitoneal 1mg/kg (1mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3713-83,
rat LD50 intravenous 37mg/kg (37mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
rat LD50 oral 305mg/kg (305mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.
rat LD50 subcutaneous 355mg/kg (355mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.

Safety

Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Human systemic effects by intravenous route: blood leukopenia and hair changes. Experimental reproductive effects. Questionable carcinogen. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also?vincaleukoblastine and?sulfates.
Hazard Codes:?HarmfulXn,ToxicT
Risk Statements: 22-37/38-41-61-36/37/38-63-23/24/25
R22:Harmful if swallowed.?
R37/38:Irritating to respiratory system and skin.?
R41:Risk of serious damage to the eyes.?
R61:May cause harm to the unborn child.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R63:Possible risk of harm to the unborn child.?
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36/39-53-45-37/39-36/37/39?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S53:Avoid exposure - obtain special instructions before use.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S37/39:Wear suitable gloves and eye/face protection.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 1544
WGK Germany: 3
RTECS: YY8400000
F: 8-10
HazardClass: 6.1(a)
PackingGroup: II

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