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Home> CAS DataBase Listed 2 > CAS 21187-98-4
Identification of 21187-98-4
  • Name:
  • Gliclazide (Related Reference)
  • EINECS:
  • 244-260-5
  • Synonyms:
  • Urea,1-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)- (8CI); Cyclopenta[c]pyrrole, benzenesulfonamide deriv.; 1-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea; Diabezidum; Diabyl; Diamicron; Diaprel; Glimicron; Glinormax; Glyzide; N-(4-Methylbenzenesulfonyl)-N'-[3-azabicyclo(3,3,0)oct-3-yl]urea; S1702; S 852; SE 1702; Benzenesulfonamide,N-[[(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-4-methyl-;
  • InChI:
  • InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)
  • This structure is also available as a 2d Mol file
Safety Data of 21187-98-4 Properties of 21187-98-4
  • Appearance:
  • white powder
  • Molecular Weight:
  • 323.41054
  • Density:
  • 1.35 g/cm3
  • Melting Point:
  • 163-169℃
  • Storage Temperature:
  • Keep tightly closed.
  • Refractive index:
  • 1.623
  • Solubility:
  • methylene chloride: soluble
  • Stability:
  • Stable at normal temperatures and pressures. Heat.
  • Usage:
  • A sulfonylurea hypoglycemic agent. Used as an antidiabetic

  • More>>

CAS No. 21187-98-4 (Gliclazide )

  • CAS No:21187-98-4
  • Molecular Weight: 323.41054
  • Molecular Formula: C15H21N3O3S
Properties Safety and Handling MSDS NMR Spectrum Precursor and Product
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Precursor and Product
precursor:
References of Gliclazide cas 21187-98-4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 1gm/kg (1000mg/kg) ? European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 17, Pg. 81, 1982.
mouse LD50 intravenous 295mg/kg (295mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 2661, 1980.
mouse LD50 oral 3gm/kg (3000mg/kg) ? Indian Drugs. Vol. 15, Pg. 161, 1978.
mouse LD50 subcutaneous 1034mg/kg (1034mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 2661, 1980.
rat LD50 intravenous 382mg/kg (382mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 2661, 1980.
rat LD50 oral 3gm/kg (3000mg/kg) ? Indian Drugs. Vol. 15, Pg. 161, 1978.
rat LD50 subcutaneous > 1gm/kg (1000mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 2661, 1980.
women TDLo oral 9600ug/kg/24D (9.6mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Internal Medicine. Vol. 33, Pg. 163, 1994.

Safety

Hazard Codes:HarmfulXn,IrritantXi
Risk Statements:21-36/38-46-62-63
R21:Harmful in contact with skin?
R36/38:Irritating to eyes and skin
R46:May cause heritable genetic damage?
R62:Possible risk of impaired fertility?
R63:Possible risk of harm to the unborn child?
Safety Statements:25-26-36/37-53
S25:Avoid contact with eyes?
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37:Wear suitable protective clothing and gloves???
S53:Avoid exposure - obtain special instruction before use
WGK Germany:2
RTECS:YT4500000