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Home> CAS DataBase Listed 2 > CAS 25122-46-7
Identification of 25122-46-7
  • Name:
  • Clobetasol propionate (Related Reference)
  • EINECS:
  • 246-634-3
  • Synonyms:
  • Pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11b,17-dihydroxy-16b-methyl-,17-propionate (8CI); 21-Chloro-21-deoxybetamethasone 17-propionate; CCl 4725; CGP 9555; Clobederm; Clobesol; Clobetasol 17-propionate; Clobex; Dermoval; Dermovate; Dermoxinale; GR 2/925; Karison; Olux; Skin Cap; Temovate; Pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11b,16b)-;
  • InChI:
  • InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1
Safety Data of 25122-46-7 Properties of 25122-46-7
  • Appearance:
  • White Crystalline Powder
  • Molecular Weight:
  • 466.969983
  • Density:
  • 1.28 g/cm3
  • Boiling Point:
  • 569 oC at 760 mmHg
  • Melting Point:
  • 195.5-197 °C
  • Flash Point:
  • 297.9 oC
  • Refractive index:
  • 1.56
  • Solubility:
  • 3.860 mg/L?at 25 °C in water
  • Usage:
  • Topical corticosteroid. Glucocorticoid; anti-inflammatory

  • More>>

CAS No. 25122-46-7 (Clobetasol propionate )

  • CAS No:25122-46-7
  • Molecular Weight: 466.969983
  • Molecular Formula: C25H32ClFO5
Properties Safety and Handling MSDS Synthesis Route Precursor and Product
Clobetasol Propionate Dermovate 25122-46-7
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Precursor and Product
precursor:
1062-09-5
product :
References of Clobetasol propionate cas 25122-46-7

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 118mg/kg (118mg/kg) ? Drugs in Japan Vol. 6, Pg. 241, 1982.
mouse LD50 oral > 3gm/kg (3000mg/kg) ? Drugs in Japan Vol. 6, Pg. 241, 1982.
mouse LD50 subcutaneous 81700ug/kg (81.7mg/kg) ? Drugs in Japan Vol. 6, Pg. 241, 1982.
rat LD50 intraperitoneal 351mg/kg (351mg/kg) ? Drugs in Japan Vol. 6, Pg. 241, 1982.
rat LD50 oral > 3gm/kg (3000mg/kg) ? Drugs in Japan Vol. 6, Pg. 241, 1982.
rat LD50 subcutaneous 366mg/kg (366mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 1066, 1978.

Safety

Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin??
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
36:Wear suitable protective clothing
Poison by subcutaneous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F? and Cl?.

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