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Home> CAS DataBase Listed 2 > CAS 26833-87-4
Identification of 26833-87-4
  • Name:
  • Homoharringtonine (Related Reference)
  • Synonyms:
  • Cephalotaxine,4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]-; Homoharringtonine (8CI); CGX 635; Ceflatonin; Myelostat; NSC 141633; Omacetaxine mepesuccinate; Ephalotaxine, 4-methyl(2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester);
  • InChI:
  • InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25+,28-,29?/m0/s1
Safety Data of 26833-87-4 Properties of 26833-87-4
  • Appearance:
  • Off-white Cryst
  • Molecular Weight:
  • 545.62126
  • Density:
  • 1.33 g/cm3
  • Boiling Point:
  • 713.1 ºC at 760 mmHg
  • Melting Point:
  • 144-146 °C
  • Flash Point:
  • 385.1 ºC
  • Storage Temperature:
  • 2-8°C
  • Refractive index:
  • 1.604
  • Solubility:
  • Soluble in DMSO or 100% ethanol.
  • Biological Activity:
  • Inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic.
  • Usage:
  • Homoharringtonine (HHT) combined with some botanical drugs could induce cancer cells to resemble normal cells. HHT was prepared by a semi-synthetic method from Cephalotaxine, a major alkaloid of Cepahlotaxus species through the formation of a-ketoes

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CAS No. 26833-87-4 (Homoharringtonine )

  • CAS No:26833-87-4
  • Molecular Weight: 545.62126
  • Molecular Formula: C29H39NO9
Properties Safety and Handling MSDS NMR Spectrum Precursor and Product
homoharringtonine
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Precursor and Product
References of Homoharringtonine cas 26833-87-4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD10 intravenous 640ug/kg (0.64mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

CARDIAC: CHANGE IN RATE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Cancer Institute Report. Vol. AUG1982,
mouse LD50 intraperitoneal 3170ug/kg (3.17mg/kg) ? Chinese Medical Journal Vol. 92, Pg. 175, 1979.
mouse LD50 intravenous 2400ug/kg (2.4mg/kg) ? Journal of Ethnopharmacology. Vol. 24, Pg. 1, 1988.
mouse LD50 oral 7456ug/kg (7.456mg/kg) ? National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 subcutaneous 3948ug/kg (3.948mg/kg) ? National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,

Safety

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
Safety information of Homoharringtonine (CAS NO.26833-87-4):
Hazard Codes: T+,Xi
Risk Statements: 26/27/28-36/37/38
R26/27/28: Very Toxic by inhalation, in contact with skin and if swallowed
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 36/37/39-45-27-26
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S27: Take off immediately all contaminated clothing
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
RIDADR: UN 1544 6.1/PG 2
WGK Germany: 3
RTECS: FK0260000
HazardClass: 6.1(a)
PackingGroup: II