In recent years, scientists has been using thiophene-2-ethylamine(CAS No. 30433-91-1) as raw material to develop a variety of prospects for the development of drugs. There are three synthetic routes of tThiophene-2-ethylamine, which have been widely used in industrialization or industrial applications. Each synthetic route has its advantages and disadvantages. Because of technical synthesis difficulty and low product yield In recent years, scholars has been continuing to optimize the based on the reaction conditions. Improving and refining these synthetic technologies is expected to reduce production costs, to improve product yield & quality and to achieved the desired results.
Synthetic Route 1
Thiophene-2-ethylamine(CAS No. 30433-91-1) is obtained from thiophene by Vilsmeier reaction and condensed with nitromethane, then reduced by diborane. The whole process is a lengthy reaction process, but this synthetic route results in relatively high yield and good product quality.
Synthetic Route 2
Thiophene-2-ethylamine(CAS No. 30433-91-1) is prepared from thiophene by Vilsmeier reaction, and with isopropyl chlorocetate by Darzens reaction, then reduced by 2-thienylacetaldehyde. Chloroacetic isopropyl or ethyl chloroacetate route create less environmental pollution. And it is cheap and easy to get the raw materials used. But Synthetic Route 1 is low at the product yield compared to Synthetic Route 1. If further optimized, Synthetic Route 2 would be regarded as a prospective industrialized route.
Synthetic Route 3
Thiophene is reacted with formaldehyde and hydrogen chloride to give 2-chloromethythiophene, then the object compound, 2-(2-thienyl)ethylamine is synthesized from 2-chloromethylthiophene via substitution, then reduced by LiAlH4. Fewer steps are in the the synthesis based on mild reaction conditions. And the product yield is higher. But the disadvantage is that using highly toxic chemicals-sodium cyanide can generate a certain amount of wastewater containing cyanide, which is a more serious environmental pollution. However, this synthetic route of thiophene-2-ethylamine(CAS No. 30433-91-1) is still regarded as a preferred industrialized route.