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Home> CAS DataBase Listed 3 > CAS 32986-56-4
Identification of 32986-56-4
  • Name:
  • Tobramycin (Related Reference)
  • EINECS:
  • 251-322-5
  • Synonyms:
  • D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-4))-2-deoxy- ; Deoxykanamycin B ; Gotabiotic ; Nebramycin ; O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-6))-2-deoxy-L-streptamine; O-3-Amino-3-deoxy-alpha-D-lucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ibohexopyranosyl-(1-4))-2-deoxy-D-streptamine; Tobamycin Base; Sulfate sterile;
  • InChI:
  • InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1
  • This structure is also available as a 2d Mol file
Safety Data of 32986-56-4 Properties of 32986-56-4
  • Appearance:
  • white solid
  • Molecular Weight:
  • 467.51448
  • Density:
  • 1.52 g/cm3
  • Boiling Point:
  • 775.4 °C at 760 mmHg
  • Melting Point:
  • 178 °C
  • Flash Point:
  • 422.8 °C
  • Storage Temperature:
  • 2-8°C
  • Refractive index:
  • 143 ° (C=4, H2O)
  • Solubility:
  • Very soluble in water
  • Stability:
  • Stable at normal temperatures and pressures.
  • Usage:
  • Single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex produced by Streptomyces tenebrarius. Antibacterial

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CAS No. 32986-56-4 (Tobramycin )

  • CAS No:32986-56-4
  • Molecular Weight: 467.51448
  • Molecular Formula: C18H37N5O9
Properties Safety and Handling MSDS NMR Spectrum Synthesis Route Precursor and Product
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Precursor and Product
precursor:
23155-02-4
product :
References of Tobramycin cas 32986-56-4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 37714ug/kg (37.714mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED American Journal of Kidney Diseases. Vol. 23, Pg. 118, 1994.
mouse LD50 intramuscular 440mg/kg (440mg/kg) ? Yakkyoku. Pharmacy. Vol. 27, Pg. 1467, 1976.
mouse LD50 intraperitoneal 445mg/kg (445mg/kg) ? Journal of International Medical Research. Vol. 2, Pg. 100, 1974.
mouse LD50 intravenous 72500ug/kg (72.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Antibiotiki. Vol. 29, Pg. 361, 1984.
mouse LD50 oral > 11500mg/kg (11500mg/kg) ? Yakkyoku. Pharmacy. Vol. 27, Pg. 1467, 1976.
mouse LD50 subcutaneous 367mg/kg (367mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Toxicology and Applied Pharmacology. Vol. 25, Pg. 398, 1973.
pig LD50 subcutaneous 676mg/kg (676mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 25, Pg. 398, 1973.
rat LD50 intramuscular 913mg/kg (913mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 107, 1977.
rat LD50 intraperitoneal 1030mg/kg (1030mg/kg) ? Journal of International Medical Research. Vol. 2, Pg. 100, 1974.
rat LD50 intravenous 104mg/kg (104mg/kg) ? Journal of International Medical Research. Vol. 2, Pg. 100, 1974.
rat LD50 oral > 7500mg/kg (7500mg/kg) ? Yakkyoku. Pharmacy. Vol. 27, Pg. 1467, 1976.
rat LD50 subcutaneous 969mg/kg (969mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION Toxicology and Applied Pharmacology. Vol. 22, Pg. 332, 1972.

Safety

Safty information about Tobramycin (CAS NO.32986-56-4) is:
Poison by intravenous and subcutaneous routes. Moderately toxic by intramuscular and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:?IrritantXi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: WK2100000
F: 3-10