Tobramycin (cas 32986-56-4) Molecular Structure

CAS No. 32986-56-4 (Tobramycin )

Molecular Formula: C18H37N5O9Molecular Weight: 467.51448

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References of Tobramycin cas 32986-56-4

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 37714ug/kg (37.714mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED American Journal of Kidney Diseases. Vol. 23, Pg. 118, 1994.
mouse LD50 intramuscular 440mg/kg (440mg/kg) ? Yakkyoku. Pharmacy. Vol. 27, Pg. 1467, 1976.
mouse LD50 intraperitoneal 445mg/kg (445mg/kg) ? Journal of International Medical Research. Vol. 2, Pg. 100, 1974.
mouse LD50 intravenous 72500ug/kg (72.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Antibiotiki. Vol. 29, Pg. 361, 1984.
mouse LD50 oral > 11500mg/kg (11500mg/kg) ? Yakkyoku. Pharmacy. Vol. 27, Pg. 1467, 1976.
mouse LD50 subcutaneous 367mg/kg (367mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Toxicology and Applied Pharmacology. Vol. 25, Pg. 398, 1973.
pig LD50 subcutaneous 676mg/kg (676mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 25, Pg. 398, 1973.
rat LD50 intramuscular 913mg/kg (913mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 107, 1977.
rat LD50 intraperitoneal 1030mg/kg (1030mg/kg) ? Journal of International Medical Research. Vol. 2, Pg. 100, 1974.
rat LD50 intravenous 104mg/kg (104mg/kg) ? Journal of International Medical Research. Vol. 2, Pg. 100, 1974.
rat LD50 oral > 7500mg/kg (7500mg/kg) ? Yakkyoku. Pharmacy. Vol. 27, Pg. 1467, 1976.
rat LD50 subcutaneous 969mg/kg (969mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION Toxicology and Applied Pharmacology. Vol. 22, Pg. 332, 1972.

Safety

Safty information about Tobramycin (CAS NO.32986-56-4) is:
Poison by intravenous and subcutaneous routes. Moderately toxic by intramuscular and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:?IrritantXi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: WK2100000
F: 3-10