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Home> CAS DataBase Listed 3 > CAS 33069-62-4
Identification of 33069-62-4
  • Name:
  • Paclitaxel (Related Reference)
  • EINECS:
  • 205-285-7
  • Synonyms:
  • 7,11-methano-5h-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid deriv.; taxal; taxol a
  • InChI:
  • InChI=1/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35+,36+,37+,38-,40-,45+,46-,47+/m0/s1
  • This structure is also available as a 2d Mol file
Safety Data of 33069-62-4 Properties of 33069-62-4
  • Appearance:
  • White Powder
  • Molecular Weight:
  • 853.92
  • Density:
  • 1.39g/cm3
  • Boiling Point:
  • 957.115 °C at 760 mmHg
  • Melting Point:
  • 213-216℃
  • Flash Point:
  • 532.644 °C
  • Storage Temperature:
  • 2-8°C
  • Refractive index:
  • -49 ° (C=1, MeOH)
  • Solubility:
  • solubile in methanol: 50 mg/mL, clear, colorless
  • Biological Activity:
  • Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.
  • Stability:
  • Stable. Incompatible with strong oxidizing agents. Combustible.
  • Usage:
  • An antineoplastic. Used in the study of structure and function of microtubles into tubulin

  • More>>

CAS No. 33069-62-4 (Paclitaxel )

  • CAS No:33069-62-4
  • Molecular Weight: 853.92
  • Molecular Formula: C47H51NO14
Properties Safety and Handling MSDS Synthesis Route Precursor and Product
Pure Paclitaxel CAS: 33069-62-4
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Paclitaxel (Related Reference)
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Precursor and Product
References of Paclitaxel cas 33069-62-4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 15mg/kg (15mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
National Technical Information Service. Vol. PB83-170969,
mouse LD50 intraperitoneal 128mg/kg (128mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER National Technical Information Service. Vol. PB83-170969,
mouse LD50 intravenous 12mg/kg (12mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Pharmaceutical Research. Vol. 4, Pg. 162, 1987.
rat LD50 intraperitoneal 32530ug/kg (32.53mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. PB83-170969,
rat LDLo intravenous 85mg/kg (85mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE
Journal of Toxicological Sciences. Vol. 19(Suppl,
women LDLo intravenous 4995mg/kg/3H- (4995mg/kg) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION

BLOOD: LEUKOPENIA

BLOOD: THROMBOCYTOPENIA
Lancet. Vol. 343, Pg. 727, 1994.

Safety

Safety Information about? Paclitaxel (CAS NO.33069-62-4):
Hazard Codes:?HarmfulXn
Risk Statements: 37/38-41-42/43-62-68-40-48-20/21/22
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.?
R37/38: Irritating to respiratory system and skin.?
R40: Limited evidence of a carcinogenic effect.
R41: Risk of serious damage to the eyes.?
R42/43: May cause sensitization by inhalation and skin contact.?
R48: Danger of serious damage to health by prolonged exposure.?
R62: Risk of impaired fertility.?
R68: Possible risk of irreversible effects.
Safety Statements: 22-26-36/37/39-45
S22: Do not breathe dust.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 1544
WGK Germany: 3
RTECS: DA8340700
F: 10-21
HazardClass: 6.1(b)
PackingGroup: III