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Home> CAS DataBase Listed 3 > CAS 36322-90-4
Identification of 36322-90-4
  • Name:
  • piroxicam usp (Related Reference)
  • EINECS:
  • 252-974-3
  • Synonyms:
  • PIROXICAM; 4-hydroxy-2-methyl-n-2-pyridinyl-2h-1,2-benzothiazine-3-carboxamide 1,1-dioxide
  • InChI:
  • InChI=1/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)
  • This structure is also available as a 2d Mol file
Safety Data of 36322-90-4 Properties of 36322-90-4
  • Appearance:
  • Off-white to pale yellow solid
  • Molecular Weight:
  • 331.34
  • Density:
  • 1.563 g/cm3
  • Melting Point:
  • 198-200 °C
  • Storage Temperature:
  • 2-8°C
  • Refractive index:
  • 1.714
  • Solubility:
  • Soluble
  • Biological Activity:
  • Anti-inflammatory; highly selective inhibitor of COX-1 (ratio of IC 50 values for COX-2/COX-1 ~ 600).
  • Stability:
  • Stable at normal temperatures and pressures.
  • Usage:
  • Non-steroidal anti-inflammatory with long half-life. Cyclooxygenase inhibitor. Clinically useful NSAID

  • More>>

CAS No. 36322-90-4 (piroxicam usp )

  • CAS No:36322-90-4
  • Molecular Weight: 331.34
  • Molecular Formula: C15H13N3O4S
Properties Safety and Handling MSDS NMR Spectrum Precursor and Product
 
 
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Precursor and Product
References of piroxicam usp cas 36322-90-4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 7143ug/kg (7.143mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BLOOD: APLASTIC ANEMIA
South African Medical Journal. Vol. 66, Pg. 31, 1984.
dog LD50 oral 108mg/kg (108mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4639, 1980.
guinea pig LD50 oral 388mg/kg (388mg/kg) ? Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
hamster LD50 oral 170mg/kg (170mg/kg) ? Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
man LDLo oral 3714mg/kg/13D (3714mg/kg) BLOOD: AGRANULOCYTOSIS
SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"
New England Journal of Medicine. Vol. 309, Pg. 795, 1983.
man TDLo oral 52mg/kg/26W-I (52mg/kg) ? Annals of Internal Medicine. Vol. 99, Pg. 282, 1983.
man TDLo oral 7636mg/kg/6W- (7636mg/kg) KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS American Journal of Nephrology. Vol. 5, Pg. 142, 1985.
monkey LD50 oral 1gm/kg (1000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4639, 1980.
mouse LD50 intraperitoneal 290mg/kg (290mg/kg) ? Russian Pharmacology and Toxicology Vol. 49, Pg. 98, 1986.
mouse LD50 oral 250mg/kg (250mg/kg) ? European Patent Application. Vol. #0079639,
mouse LD50 subcutaneous 300mg/kg (300mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4639, 1980.
rat LD50 intraperitoneal 335mg/kg (335mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4639, 1980.
rat LD50 oral 216mg/kg (216mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1714, 1978.
rat LD50 rectal 400mg/kg (400mg/kg) BEHAVIORAL: ANALGESIA Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 87, 1981.
rat LD50 skin > 5gm/kg (5000mg/kg) ? Yakkyoku. Pharmacy. Vol. 37(11), Pg. -, 1986.
rat LD50 subcutaneous 148mg/kg (148mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 4639, 1980.
women LDLo oral 2400ug/kg (2.4mg/kg) LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"
KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
British Medical Journal. Vol. 293, Pg. 540, 1986.
women TDLo oral 400ug/kg (0.4mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Allergy. Vol. 52(Suppl,
women TDLo oral 1200ug/kg/3D- (1.2mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Journal of Rheumatology. Vol. 11, Pg. 554, 1984.
women TDLo oral 28mg/kg (28mg/kg) BEHAVIORAL: HEADACHE
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM DUODENUM
GASTROINTESTINAL: NAUSEA OR VOMITING
Acta Medica Scandinavica. Vol. 216, Pg. 335, 1984.
?

Safety

Hazard Codes:? Xn,? F
Risk Statements:
22:? Harmful if swallowed?
Safety Statements:
26:? In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
36:? Wear suitable protective clothing?

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