Cimetidine (cas 51481-61-9) Molecular Structure

CAS No. 51481-61-9 (Cimetidine )

Molecular Formula: C10H16N6SMolecular Weight: 252.34

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References of Cimetidine cas 51481-61-9

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 100mg/kg (100mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP Annals of Internal Medicine. Vol. 97, Pg. 283, 1982.
dog LD50 intravenous 206mg/kg (206mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

GASTROINTESTINAL: OTHER CHANGES
Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 2806, 1980.
dog LD50 oral 2600mg/kg (2600mg/kg) ? Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 329, 1977.
hamster LD50 intraperitoneal 880mg/kg (880mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Gastroenterology. Vol. 74, Pg. 339, 1978.
hamster LD50 oral 4gm/kg (4000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Gastroenterology. Vol. 74, Pg. 339, 1978.
human TDLo oral 80mg/kg/8D (80mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

BLOOD: LEUKOPENIA
Lancet. Vol. 1, Pg. 444, 1978.
man TDLo intravenous 4286ug/kg/30M (4.286mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER
Annals of Internal Medicine. Vol. 97, Pg. 374, 1982.
man TDLo oral 2857ug/kg (2.857mg/kg) CARDIAC: OTHER CHANGES Lancet. Vol. 1, Pg. 225, 1987.
man TDLo oral 51mg/kg/3D-I (51mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" American Journal of Medicine. Vol. 75, Pg. 875, 1983.
man TDLo oral 57mg/kg/5D-I (57mg/kg) LIVER: "JAUNDICE, CHOLESTATIC" Digestive Diseases and Sciences. Vol. 32, Pg. 333, 1987.
man TDLo oral 270mg/kg/3W-I (270mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS
American Journal of Medicine. Vol. 70, Pg. 1272, 1981.
man TDLo unreported 600mg/kg/6W (600mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Lancet. Vol. 1, Pg. 1160, 1981.
mouse LD50 intraperitoneal 306mg/kg (306mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1655, 1983.
mouse LD50 intravenous 150mg/kg (150mg/kg) ? Journal of International Medical Research. Vol. 3, Pg. 86, 1975.
mouse LD50 oral 2550mg/kg (2550mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 1685, 1983.
mouse LD50 subcutaneous 437mg/kg (437mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 1685, 1983.
rabbit LD50 intraperitoneal 1063mg/kg (1063mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 1685, 1983.
rabbit LD50 intravenous 164mg/kg (164mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 1685, 1983.
rabbit LD50 oral > 8640mg/kg (8640mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 1685, 1983.
rat LD50 intraperitoneal 328mg/kg (328mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 1685, 1983.
rat LD50 intravenous 106mg/kg (106mg/kg) ? Journal of International Medical Research. Vol. 3, Pg. 86, 1975.
rat LD50 oral 5gm/kg (5000mg/kg) ? Journal of International Medical Research. Vol. 3, Pg. 86, 1975.
rat LD50 subcutaneous 860mg/kg (860mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 1685, 1983.
women LDLo intravenous 1008mg/kg/6W- (1008mg/kg) VASCULAR: OTHER CHANGES Drug Intelligence and Clinical Pharmacy. Vol. 17, Pg. 126, 1983.
women TDLo intravenous 4mg/kg/2M-C (4mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP Lancet. Vol. 1, Pg. 99, 1987.
women TDLo oral 30mg/kg/2D-I (30mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: REGIDITY

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Annals of Emergency Medicine. Vol. 16, Pg. 1162, 1987.

Safety

Hazard Codes:?ToxicT,HarmfulXn
Risk Statements: 60-42/43-36/37/38-20/22?
R60:May impair fertility.?
R42/43:May cause sensitization by inhalation and skin contact.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R20/22:Harmful by inhalation and if swallowed.
Safety Statements: 53-26-36/37/39-45-36-22?
S53:Avoid exposure - obtain special instructions before use.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36:Wear suitable protective clothing.?
S22:Do not breathe dust.
WGK Germany: 3
RTECS of Cimetidine (CAS NO.51481-61-9): MF0035500