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Home> CAS DataBase Listed 5 > CAS 56-75-7
Identification of 56-75-7
  • Name:
  • chloroamphenicol (Related Reference)
  • EINECS:
  • 200-287-4
  • Synonyms:
  • chloramphenicol; 2,2-dichloro-n-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide; d-(-)-threo-2,2-dichloro-n-[beta-hydroxy-alpha-(hydroxy-methyl)-p-nitrophenethyl]acetamide; chloromycetin
  • InChI:
  • InChI=1/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
  • This structure is also available as a 2d Mol file
Safety Data of 56-75-7 Properties of 56-75-7
  • Appearance:
  • white to off-white crystalline powder
  • Molecular Weight:
  • 323.13
  • Density:
  • 1.547 g/cm3
  • Boiling Point:
  • 644.9 oC at 760 mmHg
  • Melting Point:
  • 149-153℃
  • Flash Point:
  • 343.8 oC
  • Alpha:
  • 19.5 o (C=6, ETOH)
  • Storage Temperature:
  • 2-8°C
  • Refractive index:
  • 20 ° (C=5, EtOH)
  • Solubility:
  • Slightly soluble
  • Stability:
  • Stable under normal shipping and handling conditions.
  • Usage:
  • Broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial

  • More>>

CAS No. 56-75-7 (chloroamphenicol )

  • CAS No:56-75-7
  • Molecular Weight: 323.13
  • Molecular Formula: C11H12Cl2N2O5
Properties Safety and Handling MSDS NMR Spectrum Precursor and Product
(-)-Chloramphenicol
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Precursor and Product
References of chloroamphenicol cas 56-75-7

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo unreported 250mg/kg/10D (250mg/kg) LIVER: OTHER CHANGES

BLOOD: HEMORRHAGE

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE
Clinical Pediatrics Vol. 14, Pg. 499, 1975.
dog LD intramuscular > 101mg/kg (101mg/kg) ? Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949.
dog LD oral > 300mg/kg (300mg/kg) ? Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949.
dog LDLo intravenous 150mg/kg (150mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Bacteriology. Vol. 55, Pg. 425, 1948.
guinea pig LD50 intravenous 560mg/kg (560mg/kg) ? Farmaco, Edizione Scientifica. Vol. 9, Pg. 21, 1954.
guinea pig LD50 oral 500mg/kg (500mg/kg) ? Farmaco, Edizione Scientifica. Vol. 10, Pg. 3, 1955.
infant LDLo intravenous 30mg/kg/3D-I (30mg/kg) CARDIAC: CARDIAC OUTPUT

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Pediatrics. Vol. 103, Pg. 487, 1983.
infant LDLo unreported 200mg/kg/4D-I (200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"

BLOOD: EOSINOPHILIA
Lancet. Vol. 1, Pg. 555, 1986.
infant TDLo intramuscular 250mg/kg/2D (250mg/kg) VASCULAR: CHANGE IN PLASMA OR BLOOD VALUME New England Journal of Medicine. Vol. 262, Pg. 787, 1960.
infant TDLo oral 440mg/kg (440mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: OTHER CHANGES
JAMA, Journal of the American Medical Association. Vol. 234, Pg. 149, 1975.
mouse LD50 intraperitoneal 1100mg/kg (1100mg/kg) ? Dissertationes Pharmaceuticae. Vol. 14, Pg. 21, 1962.
mouse LD50 intravenous 110mg/kg (110mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949.
mouse LD50 oral 1500mg/kg (1500mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 1, 1955.
mouse LD50 subcutaneous 400mg/kg (400mg/kg) ? "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 493, 1978.
rabbit LD50 intravenous 117mg/kg (117mg/kg) ? Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949.
rat LD50 intraperitoneal 1811mg/kg (1811mg/kg) ? Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 intravenous 171mg/kg (171mg/kg) ? Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949.
rat LD50 oral 2500mg/kg (2500mg/kg) ? Farmaco, Edizione Scientifica. Vol. 10, Pg. 3, 1955.
rat LD50 subcutaneous 5gm/kg (5000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Toxicology and Applied Pharmacology. Vol. 9, Pg. 445, 1966.
women LDLo oral 400mg/kg (400mg/kg) BEHAVIORAL: COMA

VASCULAR: SHOCK

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
JAMA, Journal of the American Medical Association. Vol. 234, Pg. 149, 1975.

Safety

?Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by an unknown route: changes in plasma or blood volume, unspecified liver effects, and hemorrhaging. Experimental teratogenic and reproductive effects. Human mutation data reported. An antibiotic. When heated to decomposition it emits very toxic fumes of NOx and Cl?.
Hazard Codes:?T
Risk Statements: 45?
R45:May cause cancer.
Safety Statements: 53-45?
S53:Avoid exposure - obtain special instructions before use.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 2811
WGK Germany: 3
RTECS of Chloramphenicol (CAS NO.56-75-7): AB6825000