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Home> CAS DataBase Listed 5 > CAS 56390-09-1
Identification of 56390-09-1
  • Name:
  • Epirubicin hydrochloride (Related Reference)
  • EINECS:
  • 260-145-2
  • Synonyms:
  • 5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S,10S)- (9CI); 5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S-cis)-; 4'-Epidoxorubicin hydrochloride; 4'-epi-Adriamycinhydrochloride; Ellence; Epidoxorubicin hydrochloride;
  • InChI:
  • InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10?,13?,15-,17?,22?,27-;/m0./s1
  • This structure is also available as a 2d Mol file
Safety Data of 56390-09-1 Properties of 56390-09-1
  • Appearance:
  • Orange-Red Crystalline Solid
  • Molecular Weight:
  • 579.9802
  • Density:
  • 1.61g/cm3
  • Boiling Point:
  • 810.3 °C at 760 mmHg
  • Melting Point:
  • 185°C dec
  • Flash Point:
  • 443.8 °C
  • Storage Temperature:
  • Desiccate at +4°C
  • Refractive index:
  • 1.709
  • Solubility:
  • Soluble in water and in methanol
  • Biological Activity:
  • Antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC 50 = 62.7 μ M in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.
  • Usage:
  • Used as an antineoplastic

  • More>>

CAS No. 56390-09-1 (Epirubicin hydrochloride )

  • CAS No:56390-09-1
  • Molecular Weight: 579.9802
  • Molecular Formula: C27H29NO11.HCl
Properties Safety and Handling MSDS NMR Spectrum
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References of Epirubicin hydrochloride cas 56390-09-1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 2250ug/kg (2.25mg/kg) ? Drugs in Japan Vol. -, Pg. 200, 1990.
mouse LD50 intravenous 31500ug/kg (31.5mg/kg) ? Drugs in Japan Vol. -, Pg. 200, 1990.
mouse LD50 oral > 2gm/kg (2000mg/kg) ? Drugs in Japan Vol. -, Pg. 200, 1990.
mouse LD50 subcutaneous 37500ug/kg (37.5mg/kg) ? Drugs in Japan Vol. -, Pg. 200, 1990.
rat LD50 intraperitoneal 10800ug/kg (10.8mg/kg) ? Drugs in Japan Vol. -, Pg. 200, 1990.
rat LD50 intravenous 17mg/kg (17mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995.
rat LD50 oral 1350mg/kg (1350mg/kg) ? Drugs in Japan Vol. -, Pg. 200, 1990.
rat LD50 subcutaneous 17600ug/kg (17.6mg/kg) ? Drugs in Japan Vol. -, Pg. 200, 1990.
women TDLo intravenous 1622mg/kg (1622mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Lancet. Vol. 2, Pg. 629, 1986.

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