Quinine dihydrochloride (cas 60-93-5) Molecular Structure

CAS No. 60-93-5 (Quinine dihydrochloride )

Molecular Formula: C20H26Cl2N2O2Molecular Weight: 397.38

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    DetailDesc: EC NO:200-493-4 INCHI:InChI=1/C20H24N2O2.2ClH/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;2*1H/t13-,14-,19-,20+;;/m0../s1 MF:C 20 H 24 N 2 O 2 路2(HCl) MW:397.34 Synonyms: Quinine Dihydochloride;

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References of Quinine dihydrochloride cas 60-93-5

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 630mg/kg/1W-I (630mg/kg) SENSE ORGANS AND SPECIAL SENSES: "RETINAL CHANGES (PIGMENTARY DEPOSITIONS, RETINITIS, OTHER): EYE"

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

GASTROINTESTINAL: NAUSEA OR VOMITING
Japanese Journal of Ophthalmology. Vol. 28, Pg. 409, 1984.
guinea pig LD50 intravenous 57mg/kg (57mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
guinea pig LDLo subcutaneous 199mg/kg (199mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 32, Pg. 595, 1935.
mouse LD50 intravenous 86mg/kg (86mg/kg)   Biochemical Journal. Vol. 28, Pg. 426, 1934.
mouse LD50 oral 660mg/kg (660mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rabbit LD50 intravenous 35mg/kg (35mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rabbit LD50 oral 641mg/kg (641mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rat LD50 intravenous 78mg/kg (78mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.
rat LD50 oral 1392mg/kg (1392mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947.

Safety

Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. Safety Information of Quinine dihydrochloride (CAS NO.60-93-5) is:
Hazard Codes: Xi
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin 
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 36: Wear suitable protective clothing   
RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III