Benzoicacid, 2-[(2,3-dimethylphenyl)amino]- (cas 61-68-7) Molecular Structure

CAS No. 61-68-7 (Benzoicacid, 2-[(2,3-dimethylphenyl)amino]- )

Molecular Formula: C15H15 N O2Molecular Weight: 241.2851

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References of Benzoicacid, 2-[(2,3-dimethylphenyl)amino]- cas 61-68-7

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intravenous 100mg/kg (100mg/kg) ? Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976.
man TDLo oral 14285ug/kg/3D (14.285mg/kg) ? British Journal of Clinical Practice. Vol. 49, Pg. 161, 1995.
man TDLo oral 14285ug/kg/3D (14.285mg/kg) ? British Journal of Clinical Practice. Vol. 49, Pg. 161, 1995.
man TDLo oral 257mg/kg/12D- (257mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" British Medical Journal. Vol. 291, Pg. 661, 1985.
man TDLo oral 840mg/kg/6W-I (840mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
British Medical Journal. Vol. 287, Pg. 1626, 1983.
mouse LD50 intramuscular 400mg/kg (400mg/kg) ? Pharmaceutical Chemistry Journal Vol. 17, Pg. 353, 1983.
mouse LD50 intraperitoneal 120mg/kg (120mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 36, 1969.
mouse LD50 intravenous 96mg/kg (96mg/kg) ? Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 1392, 1969.
mouse LD50 oral 525mg/kg (525mg/kg) ? Journal de Pharmacologie. Vol. 2, Pg. 259, 1971.
mouse LDLo subcutaneous > 2gm/kg (2000mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1579, 1970.
rat LD50 intraperitoneal 327mg/kg (327mg/kg) ? Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 intravenous 112mg/kg (112mg/kg) ? Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976.
rat LD50 oral 740mg/kg (740mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 28, Pg. 99, 1981.
women LDLo oral 280mg/kg/2W-I (280mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA
Drug Safety. Vol. 6, Pg. 230, 1991.
women TDLo oral 20mg/kg/4D-I (20mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS Canadian Medical Association Journal. Vol. 126, Pg. 894, 1982.
women TDLo oral 450mg/kg (450mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: TOXIC PSYCHOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
South African Medical Journal. Vol. 67, Pg. 823, 1985.
women TDLo unreported 120mg/kg/4D (120mg/kg) BEHAVIORAL: WITHDRAWAL

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Lancet. Vol. 2, Pg. 745, 1980.

Safety

Safty information about Mefenamic acid (CAS NO.61-68-7) is:
Hazard Codes:?Xn
Risk Statements: 22-40-20/21/22?
R22:Harmful if swallowed.?
R40:Limited evidence of a carcinogenic effect.?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-36
S22:Do not breathe dust.?
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: CB4550000