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Home> CAS DataBase Listed 6 > CAS 6211-32-1
Identification of 6211-32-1
  • Name:
  • Yohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, hydrochloride (1:1), (16b,17a,20a)- (Related Reference)
  • EINECS:
  • 208-977-7
  • Synonyms:
  • 20a-Yohimban-16b-carboxylic acid, 17a-hydroxy-, methyl ester,monohydrochloride (8CI); Yohimban-16-carboxylic acid, 17-hydroxy-, methylester, monohydrochloride, (16b,17a,20a)- (9CI); NSC 407307; Rauwolscine hydrochloride; a-Yohimbine hydrochloride
  • InChI:
  • InChI=1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15+,17+,18+,19+;/m1./s1
  • This structure is also available as a 2d Mol file
Safety Data of 6211-32-1 Properties of 6211-32-1
  • Appearance:
  • white solid
  • Molecular Weight:
  • 390.90368
  • Density:
  • 1.31 g/cm3
  • Boiling Point:
  • 543 °C at 760 mmHg
  • Melting Point:
  • 270-280°C
  • Flash Point:
  • 282.2 °C
  • Storage Temperature:
  • Store at RT
  • Solubility:
  • H2O: soluble in water
  • Biological Activity:
  • Standard α 2 -adrenergic antagonist (K i values are 3.5, 4.6 , and 0.6 nM at cloned human α 2A , α 2B , and α 2C -adrenoceptors respectively). Partial agonist at 5-HT 1A receptors. Also available as part of the α 2 -Adrenoceptor Tocriset™ .
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CAS No. 6211-32-1 (Yohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, hydrochloride (1:1), (16b,17a,20a)- )

  • CAS No:6211-32-1
  • Molecular Weight: 390.90368
  • Molecular Formula: C21H26 N2 O3 . Cl H
Properties Safety and Handling MSDS
Rauwolscine hydrochloride
  • FOB Price:1 USD/Kilogram 
  • Cas No:6211-32-1 
  • Min.Order:1/Kilogram 
  • Purity:95%, 99% 
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  • Formula:C21H26 N2 O3 . Cl H 
  • Payment:T/T, L/C 
  • Updatetime:Jun 15 2018 
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  • Formula:C21H26 N2 O3 . Cl H 
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ALPHA YOHIMBINE(RAUWOLSCINE) 90% 98%
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  • Purity:99% 
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  • Formula:C21H26 N2 O3 . Cl H 
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  • Formula:C21H26 N2 O3 . Cl H 
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  • Formula:C21H26 N2 O3 . Cl H 
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  • Updatetime:Mar 29 2016 
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  • Formula:C21H26 N2 O3 . Cl H 
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  • Cas No:6211-32-1 
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  • Formula:C21H26 N2 O3 . Cl H 
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Rauwolscine hydrochloride
  • FOB Price:  
  • Cas No:6211-32-1 
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  • Formula:C21H26 N2 O3 . Cl H 
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Yohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, hydro...
  • FOB Price:  
  • Cas No:6211-32-1 
  • Min.Order: 
  • Supply Ability:  
  • Formula:C21H26 N2 O3 . Cl H 
  • Payment: 
  • Updatetime:Dec 18 2010 
Yohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, hydro...
  • FOB Price:  
  • Cas No:6211-32-1 
  • Min.Order: 
  • Supply Ability:  
  • Formula:C21H26 N2 O3 . Cl H 
  • Payment: 
  • Updatetime:Dec 18 2010 
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References of Yohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, hydrochloride (1:1), (16b,17a,20a)- cas 6211-32-1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo subcutaneous 20mg/kg (20mg/kg) BEHAVIORAL: GENERAL ANESTHETIC
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
"Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J., Institute fuer Pharmakologie und Experimentelle Therapie der Universitat Breslau, Poland, 1932Vol. -, Pg. -, 1932.
frog LD50 parenteral 200mg/kg (200mg/kg)   Bulletin des Sciences Pharmacologiques. Vol. 47, Pg. 33, 1940.
guinea pig LD50 intraperitoneal 162mg/kg (162mg/kg)   Bulletin des Sciences Pharmacologiques. Vol. 47, Pg. 33, 1940.
mouse LDLo oral 125mg/kg (125mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD "Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J., Institute fuer Pharmakologie und Experimentelle Therapie der Universitat Breslau, Poland, 1932Vol. -, Pg. -, 1932.
rabbit LDLo intravenous 2mg/kg (2mg/kg)   "Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J., Institute fuer Pharmakologie und Experimentelle Therapie der Universitat Breslau, Poland, 1932Vol. -, Pg. -, 1932.

Safety

Poison by ingestion and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also YOHIMBINE.
 

Hazard Codes of Rauwolscine hydrochloride (CAS NO.503-49-1): ToxicT
Risk Statements: 23/24/25
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-36/37/39-45
S22:Do not breathe dust. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)