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Home> CAS DataBase Listed 6 > CAS 65271-80-9
Identification of 65271-80-9
  • Name:
  • 9,10-Anthracenedione,1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]- (Related Reference)
  • EINECS:
  • 274-619-1
  • Synonyms:
  • 1,4-Bis[(2-(2-hydroxyethylamino)ethyl)amino]-5,8-dihydroxyanthraquinone; 1,4-Dihydroxy-5,8-bis-[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone; 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione; DHAQ; Dihydroxyanthraquinone; Mitoxanthrone; Mitoxantrone; Mitozantrone; NSC 279836; Novantron; Ralenova;
  • InChI:
  • InChI=1/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2
  • This structure is also available as a 2d Mol file
Safety Data of 65271-80-9 Properties of 65271-80-9
  • Appearance:
  • blue powder
  • Molecular Weight:
  • 444.48
  • Density:
  • 1.45 g/cm3
  • Boiling Point:
  • 805.7 °C at 760 mmHg
  • Melting Point:
  • 170-1740C
  • Flash Point:
  • 441.1 °C
  • Storage Temperature:
  • -20°C Freezer
  • Refractive index:
  • 1.709
  • Solubility:
  • Sparingly soluble in water; slightly sol in methanol; practically insoluble in acetonitrile chloroform; acetone
  • Usage:
  • A DNA intercalating drug. Inhibits DNA synthesis. Used as an anti-cancer agent

  • More>>

CAS No. 65271-80-9 (9,10-Anthracenedione,1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]- )

  • CAS No:65271-80-9
  • Molecular Weight: 444.48
  • Molecular Formula: C22H28N4O6
Properties Safety and Handling MSDS NMR Spectrum Synthesis Route Precursor and Product
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<Pre123Next >
Precursor and Product
References of 9,10-Anthracenedione,1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]- cas 65271-80-9

Toxicity

1. ???

mmo-sat 20?μg/plate

??? TCMUD8 ?? Teratogenesis, Carcinogenesis, and Mutagenesis. 5 (1985),319.
2. ???

cyt-hmn:lym 100 μmol/L

??? MUREAV ?? Mutation Research. 93 (1982),185.
3. ???

ipr-mus LD50:7100?μg/kg

??? HYDXET ?? Huaxi Yike Daxue Xuebao. Journal of West China University of Medical Sciences. 20 (1989),303.
4. ???

scu-mus LD50:20,910?μg/kg

??? NCISP* ?? National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 .
5. ???

ivn-mus LD50:6600?μg/kg

??? HYDXET ?? Huaxi Yike Daxue Xuebao. Journal of West China University of Medical Sciences. 20 (1989),303.

Safety

Poison by subcutaneous, intravenous, and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
?

Hazard Codes: T,T+
Risk Statements:
26: ?Very Toxic by inhalation
27: ?Very Toxic in contact with skin
28: ?Very Toxic if swallowed
46: ?May cause heritable genetic damage
61: ?May cause harm to the unborn child
Safety Statements:
22: ?Do not breathe dust
36: ?Wear suitable protective clothing?
37: ?Wear suitable gloves
39: ?Wear eye/face protection
45: ?In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53: ?Avoid exposure - obtain special instruction before use

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