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Home> CAS DataBase Listed 6 > CAS 66357-35-5
Identification of 66357-35-5
  • Name:
  • Ranitidine (Related Reference)
  • EINECS:
  • 266-332-5
  • Synonyms:
  • Midaven; Zenetac; 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-; Acidex;
  • InChI:
  • InChI=1/C13H22N4O3S/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3/h4-5,9,14-15H,6-8,10H2,1-3H3/b13-9+
  • This structure is also available as a 2d Mol file
Safety Data of 66357-35-5 Properties of 66357-35-5
  • Appearance:
  • White powder
  • Molecular Weight:
  • 350.87
  • Density:
  • 1.184 g/cm3
  • Boiling Point:
  • 437.1 °C at 760 mmHg
  • Melting Point:
  • 69-70℃
  • Flash Point:
  • 437.1 °C at 760 mmHg
  • Storage Temperature:
  • Ranitidine hydrochloride tablets or solution should be stored in a dry place at 15-30C in tight, light-resistant containers.
  • Refractive index:
  • 1.558
  • Solubility:
  • 24.7 mg/mL in water
  • Biological Activity:
  • Potent, selective and competitive histamine H 2 receptor antagonist (pA 2 = 6.95-7.2). In vivo, inhibits gastric acid secretion induced by histamine, pentagastrin, bethanecol and food. Also inhibits aspirin-induced gastric lesions.
  • Stability:
  • No data.
  • Usage:
  • Medication.

  • More>>

CAS No. 66357-35-5 (Ranitidine )

  • CAS No:66357-35-5
  • Molecular Weight: 350.87
  • Molecular Formula: C13H22N4O3S
Properties Safety and Handling MSDS NMR Spectrum Synthesis Route Precursor and Product
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Precursor and Product
References of Ranitidine cas 66357-35-5

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 4286ug/kg/2D- (4.286mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
American Journal of Emergency Medicine. Vol. 17, Pg. 258, 1999.
man TDLo oral 60mg/kg/14D-I (60mg/kg) LIVER: "JAUNDICE, CHOLESTATIC"

LIVER: LIVER FUNCTION TESTS IMPAIRED

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
American Journal of Gastroenterology. Vol. 93, Pg. 822, 1998.
mouse LD50 intramuscular 280mg/kg (280mg/kg) ? United States Patent Document. Vol. #4613602,
mouse LD50 intravenous 80mg/kg (80mg/kg) ? United States Patent Document. Vol. #4613602,
mouse LD50 oral 884mg/kg (884mg/kg) ? European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 25, Pg. 749, 1990.
rat LD50 intramuscular 2018mg/kg (2018mg/kg) ? United States Patent Document. Vol. #4613602,
rat LD50 intravenous 93mg/kg (93mg/kg) ? United States Patent Document. Vol. #4613602,
rat LD50 oral > 5gm/kg (5000mg/kg) ? United States Patent Document. Vol. #4613602,
women TDLo oral 12mg/kg/2D-I (12mg/kg) KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS

BLOOD: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER TOPICAL EXPOSURE"
American Journal of Emergency Medicine. Vol. 12, Pg. 67, 1994.

Safety

Safety Statements: 22-24/25?
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
WGK Germany: 2
RTECS: KM6557000