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Home> CAS DataBase Listed 6 > CAS 665-66-7
Identification of 665-66-7
  • Name:
  • 1-Adamantanamine hydrochloride (Related Reference)
  • EINECS:
  • 211-560-2
  • Synonyms:
  • 1-Aminoadamantane hydrochloride; Amantadine hydrochloride; AMANTADINE HCL; 1-Adamantamine hydrochloride 99%
  • InChI:
  • InChI=1/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H
  • This structure is also available as a 2d Mol file
Safety Data of 665-66-7 Properties of 665-66-7
  • Appearance:
  • Crystalline Solid
  • Molecular Weight:
  • 187.71
  • Density:
  • 1.067g/cm3
  • Boiling Point:
  • 225.7 °C at 760 mmHg
  • Melting Point:
  • 300℃
  • Flash Point:
  • 96 °C
  • Storage Temperature:
  • Store in a cool, dry place. Store in a tightly closed container.
  • Refractive index:
  • 1.558
  • Solubility:
  • 50 mg/mL in water
  • Stability:
  • No data.
  • Usage:
  • NMDA-receptor antagonist. Antiviral; antiparkinsonian

  • More>>

CAS No. 665-66-7 (1-Adamantanamine hydrochloride )

  • CAS No:665-66-7
  • Molecular Weight: 187.71
  • Molecular Formula: C10H17N?HCl
Properties Safety and Handling MSDS NMR Spectrum Synthesis Route Precursor and Product
Amantadine hydrochloride(Amantadine Hydrochloride 665-66-7...
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Precursor and Product
References of 1-Adamantanamine hydrochloride cas 665-66-7

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 37mg/kg (37mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
guinea pig LD50 oral 360mg/kg (360mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
man LDLo oral 28571ug/kg (28.571mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BLOOD: HEMORRHAGE
American Journal of Psychiatry. Vol. 145, Pg. 267, 1988.
man LDLo oral 286mg/kg (286mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TOXIC PSYCHOSIS
American Journal of Psychiatry. Vol. 145, Pg. 267, 1988.
man TDLo oral 13mg/kg/5D-I (13mg/kg) BEHAVIORAL: EUPHORIA

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
American Journal of Psychiatry. Vol. 143, Pg. 1170, 1985.
man TDLo oral 24mg/kg/1D-I (24mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: EXCITEMENT
Annals of Emergency Medicine. Vol. 19, Pg. 668, 1990.
mouse LD50 intraperitoneal 198mg/kg (198mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
mouse LD50 intravenous 95mg/kg (95mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
mouse LD50 oral 700mg/kg (700mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
mouse LD50 subcutaneous 290mg/kg (290mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 intraperitoneal 150mg/kg (150mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 15, Pg. 642, 1969.
rat LD50 intravenous 90mg/kg (90mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 oral 800mg/kg (800mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 164, 1988.
rat LD50 subcutaneous 500mg/kg (500mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 13, Pg. 1269, 1971.
women LDLo oral 50mg/kg (50mg/kg) BEHAVIORAL: COMA

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

CARDIAC: PULSE RATE
American Journal of Medicine. Vol. 77, Pg. 388, 1984.

Safety

Safety Information of Amantadine hydrochloride (CAS NO.665-66-7):
Hazard Codes: XnHarmful
Risk Statements: 22-40-20/21/22
20:?Harmful by inhalation?
21:?Harmful in contact with skin?
22:?Harmful if swallowed?
40:?Limited evidence of a carcinogenic effect?
Safety Statements: 22-36/37-36
22:?Do not breathe dust?
36:?Wear suitable protective clothing??
37:?Wear suitable gloves?

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