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Home> CAS DataBase Listed 6 > CAS 68-41-7
Identification of 68-41-7
  • Name:
  • 3-Isoxazolidinone,4-amino-, (4R)- (Related Reference)
  • EINECS:
  • 200-688-4
  • Synonyms:
  • 3-Isoxazolidinone,4-amino-, (+)- (8CI); 3-Isoxazolidinone, 4-amino-, (R)-; (+)-Cycloserine; (4R)-4-Amino-3-isoxazolidinone; (R)-4-Amino-3-isoxazolidinone; (R)-Cycloserine; Cyclo-D-serine; Cycloserine; D-4-Amino-3-isoxazolidinone; D-4-Amino-3-isoxazolidone; D-CS; Farmiserina; Micoserina; Miroseryn; NSC 154851; Novoserin; Orientomycin; Oxamycin; Seromycin; Tisomycin; Wasserina;
  • InChI:
  • InChI=1/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
  • This structure is also available as a 2d Mol file
Safety Data of 68-41-7 Properties of 68-41-7
  • Appearance:
  • white to off-white powder
  • Molecular Weight:
  • 102.09
  • Density:
  • 1.278 g/cm3
  • Boiling Point:
  • 267
  • Melting Point:
  • 147℃
  • Alpha:
  • 111 o (C=5, 2N NAOH)
  • Storage Temperature:
  • ?20°C
  • Solubility:
  • SOLUBLE IN WATER
  • Stability:
  • Stable under normal temperatures and pressures.
  • Usage:
  • In the treatment of nocardiosis, sulfonamides have been used with cycloserine.

  • More>>

CAS No. 68-41-7 (3-Isoxazolidinone,4-amino-, (4R)- )

  • CAS No:68-41-7
  • Molecular Weight: 102.09
  • Molecular Formula: C3H6N2O2
Properties Safety and Handling MSDS NMR Spectrum Precursor and Product
D-Cycloserine
  • FOB Price:550 USD/Kilogram 
  • Cas No:68-41-7 
  • Min.Order:1/Kilogram 
  • Purity:99% 
  • Supply Ability:2 Month/Metric Ton 
  • Formula:C3H6N2O2 
  • Payment: 
  • Updatetime:Jun 15 2018 
Hangzhou Utanpharma biology co,.Ltd 1YR Main Products
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D-Cycloserine
  • FOB Price:3 USD/Kilogram 
  • Cas No:68-41-7 
  • Min.Order:1/Kilogram 
  • Purity:95%, 99% 
  • Supply Ability:50 Year/Metric Ton 
  • Formula:C3H6N2O2 
  • Payment:T/T, L/C 
  • Updatetime:Jun 15 2018 
D-Cycloserine
  • FOB Price:  
  • Cas No:68-41-7 
  • Min.Order:1/Kilogram 
  • Purity:99% 
  • Supply Ability:1-100 Year/Metric Ton 
  • Formula:C3H6N2O2 
  • Payment:T/T L/C 
  • Updatetime:Jun 15 2018 
3-Isoxazolidinone,4-amino-, (4R)- CAS 68-41-7
  • FOB Price:1 USD/Gram 
  • Cas No:68-41-7 
  • Min.Order:1/Gram 
  • Purity:99% 
  • Supply Ability:100 Day/Kilogram 
  • Formula:C3H6N2O2 
  • Payment:T/T,Western Union,MoneyGram, 
  • Updatetime:Jun 14 2018 
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D-CycloserineCAS NO.: 68-41-7
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  • Cas No:68-41-7 
  • Min.Order:1/Kilogram 
  • Purity:99% 
  • Supply Ability:10 Day/Metric Ton 
  • Formula:C3H6N2O2 
  • Payment:L/C,T/T,Western Union,MoneyGram,The currency, 
  • Updatetime:Jun 14 2018 
Hebei yanxi chemical co., LTD 3YRS Main Products
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D-Cycloserine
  • FOB Price:  
  • Cas No:68-41-7 
  • Min.Order: 
  • Purity:99% 
  • Supply Ability:  
  • Formula:C3H6N2O2 
  • Payment: 
  • Updatetime:Jun 07 2018 
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D-cycloserine
  • FOB Price:  
  • Cas No:68-41-7 
  • Min.Order: 
  • Purity:97% 
  • Supply Ability:  
  • Formula:C3H6N2O2 
  • Payment: 
  • Updatetime:May 23 2018 
D-Cycloserine
  • FOB Price:  
  • Cas No:68-41-7 
  • Min.Order:1/Gram 
  • Purity:97.00% 
  • Supply Ability:10 Month/Kilogram 
  • Formula:C3H6N2O2 
  • Payment:L/C D/A D/P T/T Western Union MoneyGran 
  • Updatetime:Apr 10 2018 
Nanjing Chemlin Chemical Co., Ltd. 7YRS Main Products
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D-cycloserine
  • FOB Price:  
  • Cas No:68-41-7 
  • Min.Order: 
  • Supply Ability:  
  • Formula:C3H6N2O2 
  • Payment: 
  • Updatetime:Apr 08 2018 
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pharmaceutical intermediates and fine chemical products
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3-Isoxazolidinone,4-amino-, (4R)-
  • FOB Price:100 USD/Kilogram 
  • Cas No:68-41-7 
  • Min.Order:1/Kilogram 
  • Purity:99% 
  • Supply Ability:100 Month/Kilogram 
  • Formula:C3H6N2O2 
  • Payment:T/T 
  • Updatetime:Mar 13 2018 
Jinlan Pharm-Drugs Technology Co., Limited 5YRS Main Products
Veterinary products,Nutrition products,Agrochemicals,Active pharmaceutical Ingredients,Custom systhesis,Contract manufacturing
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D-Cycloserine
  • FOB Price:  
  • Cas No:68-41-7 
  • Min.Order:0/Metric Ton 
  • Purity:98.0%~101.0% 
  • Supply Ability:Metric Day/Ton 
  • Formula:C3H6N2O2 
  • Payment:T/T,Western Union,MoneyGram, 
  • Updatetime:May 16 2018 
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D-Cycloserine
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  • Cas No:68-41-7 
  • Min.Order:1/Gram 
  • Purity:98% 
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  • Formula:C3H6N2O2 
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  • Updatetime:Feb 06 2018 
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D-Cycloserine
  • FOB Price:1 USD/Gram 
  • Cas No:68-41-7 
  • Min.Order:1/Gram 
  • Purity:98% 
  • Supply Ability:100 Month/Kilogram 
  • Formula:C3H6N2O2 
  • Payment:TT,Western Union 
  • Updatetime:Jun 28 2017 
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D-cycloserine
  • FOB Price:800 USD/Kilogram 
  • Cas No:68-41-7 
  • Min.Order:1/Kilogram 
  • Purity:99% 
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  • Updatetime:Jun 14 2017 
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D-Cycloserine
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  • Cas No:68-41-7 
  • Min.Order: 
  • Purity:contact us for more details about D-Cycloserine, CAS:68-41-7 
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  • Formula:C3H6N2O2 
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  • Updatetime:Jun 06 2017 
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D-Cycloserine
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  • Cas No:68-41-7 
  • Min.Order:10/Gram 
  • Purity:98.00% 
  • Supply Ability:800 Month/Kilogram 
  • Formula:C3H6N2O2 
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  • Updatetime:May 24 2017 
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D-4-Amino-3-isoxazolidinone
  • FOB Price:  
  • Cas No:68-41-7 
  • Min.Order:1/Kilogram 
  • Purity:98% 
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  • Formula:C3H6N2O2 
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  • Updatetime:Dec 06 2016 
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  • FOB Price:1 USD/Kilogram 
  • Cas No:68-41-7 
  • Min.Order:10/Gram 
  • Purity:99% 
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  • Formula:C3H6N2O2 
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  • Updatetime:Sep 29 2016 
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D-Cycloserin
  • FOB Price:  
  • Cas No:68-41-7 
  • Min.Order: 
  • Supply Ability:  
  • Formula:C3H6N2O2 
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  • Updatetime:Sep 22 2016 
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D-Cycloserine
  • FOB Price:1 USD/Gram 
  • Cas No:68-41-7 
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  • Purity:99.9% 
  • Supply Ability:10 Month/Metric Ton 
  • Formula:C3H6N2O2 
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  • Updatetime:Sep 21 2016 
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Precursor and Product
References of 3-Isoxazolidinone,4-amino-, (4R)- cas 68-41-7

Toxicity

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NY2975000
CHEMICAL NAME :
3-Isoxazolidinone, 4-amino-, D-
CAS REGISTRY NUMBER :
68-41-7
BEILSTEIN REFERENCE NO. :
0080798
LAST UPDATED :
199612
DATA ITEMS CITED :
20
MOLECULAR FORMULA :
C3-H6-N2-O2
MOLECULAR WEIGHT :
102.11
WISWESSER LINE NOTATION :
T5OMVTJ DZ -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
560 mg/kg/4W-I
TOXIC EFFECTS :
Behavioral - wakefulness Behavioral - tremor
REFERENCE :
DICHAK Diseases of the Chest. (Chicago, IL) V.1-56, 1935-69. For publisher information, see CHETBF. Volume(issue)/page/year: 29,241,1956
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Behavioral - coma
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,907,1965
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
40 mg/kg/2D-I
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
REFERENCE :
TUBEAS Tubercle. (Williams & Wilkins Co., 428 E. Preston Street, Baltimore, MD 21202) V.1- 1919- Volume(issue)/page/year: 38,297,1957
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
64 mg/kg/4D-I
TOXIC EFFECTS :
Behavioral - sleep Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 3,148,1955/1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 6,360,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 6,360,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5290 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 6,360,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,238,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 31,1085,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 31,1085,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 6,360,1956
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - tremor Gastrointestinal - nausea or vomiting
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 6,708,1956
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - nausea or vomiting
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 6,708,1956
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 6,382,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 6,360,1956
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 6,360,1956 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
15 gm/kg/60D-I
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 6,708,1956
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
45 gm/kg/90D-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 6,708,1956 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5527 No. of Facilities: 31 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 756 (estimated) No. of Female Employees: 559 (estimated)

Safety

Poison by intraperitoneal route. Moderately toxic by intravenous and subcutaneous routes. Mildly toxic by ingestion. Human systemic effects by ingestion and possibly other routes: wakefulness, sleep, altered sleep time, hallucinations, distorted perceptions, tremors, convulsions, and coma. An antibiotic used in the treatment of human pulmonary tuberculosis. When heated to decomposition it emits toxic fumes of NOx.

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