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Home> CAS DataBase Listed 7 > CAS 73963-72-1
Identification of 73963-72-1
  • Name:
  • Cilostazol (Related Reference)
  • Synonyms:
  • 6-[4-(1-cyclohexyltetrazol-5-yl)butoxy]-3,4-dihydro-1H-quinolin-2-one; Pletal; OPC 13013; Cilostazol (JAN/USAN); 2(1H)-Quinolinone,6-[4-(1-cyclohexyl-1Htetrazol- 5-yl)butoxy]-3,4-dihydro-; Pletal (TN); Cilostazole; Cilostal;
  • This structure is also available as a 2d Mol file
Safety Data of 73963-72-1 Properties of 73963-72-1
  • Appearance:
  • off-white solid
  • Molecular Weight:
  • 369.52
  • Density:
  • 1.34 g/cm3
  • Boiling Point:
  • 664.7 °C at 760 mmHg
  • Melting Point:
  • 159-160°C
  • Flash Point:
  • 355.8 °C
  • Storage Temperature:
  • Store in original container in a cool dark place.
  • Refractive index:
  • 1.675
  • Solubility:
  • DMSO: 18 mg/mL, soluble
  • Biological Activity:
  • Potent phosphodiesterase III A (PDE3A) inhibitor (IC 50 = 0.2 μ M) and inhibitor of adenosine uptake. Has antimitogenic, antithrombotic, vasodilatory and cardiotonic properties in vivo . Also affects lipid levels in vivo .
  • Usage:
  • A potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo

  • More>>

CAS No. 73963-72-1 (Cilostazol )

  • CAS No:73963-72-1
  • Molecular Weight: 369.52
  • Molecular Formula: C20H27N5O2
Properties Safety and Handling MSDS NMR Spectrum Synthesis Route Precursor and Product
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Cilostazol (Related Reference)
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Precursor and Product
References of Cilostazol cas 73963-72-1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg) ? Drugs in Japan Vol. -, Pg. 504, 1990.
man TDLo oral 1248ug/kg (1.248mg/kg) BEHAVIORAL: HEADACHE Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 1173, 1985.
mouse LD50 intramuscular > 1gm/kg (1000mg/kg) ? Drugs in Japan Vol. -, Pg. 504, 1990.
mouse LD50 intraperitoneal > 2gm/kg (2000mg/kg) ? Drugs in Japan Vol. -, Pg. 504, 1990.
mouse LD50 oral > 5gm/kg (5000mg/kg) ? Drugs in Japan Vol. -, Pg. 504, 1990.
rat LD50 intramuscular > 1gm/kg (1000mg/kg) ? Drugs in Japan Vol. -, Pg. 504, 1990.
rat LD50 intraperitoneal > 2gm/kg (2000mg/kg) ? Drugs in Japan Vol. -, Pg. 504, 1990.
rat LD50 oral > 5gm/kg (5000mg/kg) ? Drugs in Japan Vol. -, Pg. 504, 1990.

Safety

Possible side effects of cilostazole use include headache (the most common), diarrhea, abnormal stools, increased heart rate, and palpitations. Although drugs similar to cilostazol have increased the risk of death in patients with congestive heart failure, studies of significant size have not addressed people without the disease.
Hazard Codes:?IrritantXi
WGK Germany: 2
RTECS: VC8277500