Lovastatin (cas 75330-75-5) Molecular Structure

CAS No. 75330-75-5 (Lovastatin )

Molecular Formula: C24H36O5Molecular Weight: 404.54

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    DetailDesc:Name: Lovastatin Molecular Formula: C24H36O5 Formula Weight: 404.54

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    DetailDesc: lovastatin Name:Lovastatin Synonym:ethyl]-1-naphthalenylester;[1s-[1alpha(r*),3alpha,7beta,8beta(2s*,4s*),8abeta]]-2-methylbutanoicacid1,2,;1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobuty;2-methyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-butanoicaci;3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl;3r,7s,8s,8ar)-1,2,3,7,8,8a...

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References of Lovastatin cas 75330-75-5

} Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 17mg/kg/3W-I (17mg/kg) BEHAVIORAL: WAKEFULNESS Lancet. Vol. 343, Pg. 973, 1994.
human TDLo oral 8750ug/kg/14D (8.75mg/kg) BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Clinical Pharmacology and Therapeutics Vol. 50, Pg. 730, 1991.
man TDLo oral 240mg/kg/60W- (240mg/kg) BEHAVIORAL: MUSCLE WEAKNESS Annals of Pharmacotherpy. Vol. 26, Pg. 190, 1992.
mouse LD50 oral > 1gm/kg (1000mg/kg) ? Journal of Antibiotics. Vol. 32, Pg. 852, 1979.
women TDLo oral 285mg/kg/30W- (285mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"

LIVER: LIVER FUNCTION TESTS IMPAIRED

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Israel Journal of Medical Sciences. Vol. 28, Pg. 101, 1992.

Safety

Hazard Codes of Lovastatin (CAS NO.75330-75-5):?IrritantXi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36/37/39-26?
S22:Do not breathe dust.?
S24/25:Avoid contact with skin and eyes.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: 3077
WGK Germany: 3
RTECS: EK7907000
HazardClass: 9
PackingGroup: III