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Home> CAS DataBase Listed 7 > CAS 7689-03-4
Identification of 7689-03-4
  • Name:
  • Camptothecine (Related Reference)
  • EINECS:
  • 444-280-6
  • Synonyms:
  • 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (+)-Camptothecin; Camptothecin, Camptotheca acuminata; 4-Ethyl-4-hydroxy-1H-pyrano-[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Camptothecin,95%; Camptothecin; 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Camptothecin
  • InChI:
  • InChI=1/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
  • This structure is also available as a 2d Mol file
Safety Data of 7689-03-4 Properties of 7689-03-4
  • Appearance:
  • light yellow crystal powde
  • Molecular Weight:
  • 348.36
  • Density:
  • 1.51 g/cm3
  • Boiling Point:
  • 264℃
  • Melting Point:
  • 260℃
  • Flash Point:
  • 411.6 °C
  • Storage Temperature:
  • 2-8°C
  • Refractive index:
  • 1.787
  • Solubility:
  • insoluble in water,chloroform/methanol (4:1): 4 mg/mL
  • Biological Activity:
  • Cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor.
  • Usage:
  • Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent
  • More>>

CAS No. 7689-03-4 (Camptothecine )

  • CAS No:7689-03-4
  • Molecular Weight: 348.36
  • Molecular Formula: C20H16N2O4
Properties Safety and Handling MSDS NMR Spectrum Precursor and Product
(S)-(+)-Camptothecin
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Precursor and Product
References of Camptothecine cas 7689-03-4

Toxicity

1.    

dnd-omi 100 mg/L/30M

    NATUAS    Nature. 248 (1974),226.
2.    

dnd-hmn:hla 20 µmol/L

    CNREA8    Cancer Research. 33 (1973),2834.
3.    

dni-hmn:hla 5 µmol/L

    HXPHAU    Handbuch der Experimentellen Pharmakologie. 38 (Pt 2),(1975),649.
4.    

oms-hmn:hla 5 µmol/L

    HXPHAU    Handbuch der Experimentellen Pharmakologie. 38 (Pt 2),(1975),649.
5.    

oms-mus:lym 1 mg/L

    BCPCA6    Biochemical Pharmacology. 21 (1972),1977.
6.    

dni-ckn:emb 500 µg/L

    CJBIAE    Canadian Journal of Biochemistry. 55 (1977),1180.
7.    

ipr-mus LD50:64 mg/kg

    CNREA8    Cancer Research. 39 (1979),2204.
8.    

ivn-mus LD50:38 mg/kg

    NCISP*    National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program, Bethesda, MD 20205 JAN86 .

Safety

Safety Information of Camptothecine (CAS NO.7689-03-4):
Hazard Codes: ToxicT,IrritantXi,HarmfulXn
Risk Statements:36/37/38-25-20/21/22
36/37/38:Irritating to eyes, respiratory system and skin 
25:Toxic if swallowed 
20/21/22:Harmful by inhalation, in contact with skin and if swallowed
Safety Statements:45-36/37/39-26-36
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
36/37/39:Wear suitable protective clothing, gloves and eye/face protection 
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36:Wear suitable protective clothing 
RIDADR:UN 1544 6.1/PG 3
WGK Germany:3
RTECS Note:UQ0492000
Hazard Note:Irritant
Poison by intravenous and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also CAMPTOTHECIN, SODIUM SALT.