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Home> CAS DataBase Listed 9 > CAS 93479-97-1
Identification of 93479-97-1
  • Name:
  • Glimepiride (Related Reference)
  • Synonyms:
  • 1h-pyrrole-1-carboxamide,2,5-dihydro-3-ethyl-4-methyl-n-(2-(4-(((((4-methylcyc; glimepirid; hoe490; trans-lohexyl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo; 1-[[p-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]phenyl]sulfonyl]-3-(trans-4-methylcyclohexyl)urea; amary; AMARYL; Glimpiride
  • InChI:
  • InChI=1/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19-
  • This structure is also available as a 2d Mol file
Safety Data of 93479-97-1 Properties of 93479-97-1
  • Appearance:
  • White Cyrstalline Solid
  • Molecular Weight:
  • 490.62
  • Density:
  • 1.29 g/cm3
  • Melting Point:
  • 212-214℃
  • Storage Temperature:
  • Room temp
  • Refractive index:
  • 1.599
  • Solubility:
  • DMSO: >10 mg/mL
  • Biological Activity:
  • Potent K ATP channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac K ATP channels with an IC 50 of 6.8 nM.
  • Usage:
  • A sulfonylurea hypoglycemic agent. Used as an antidiabetic

  • More>>

CAS No. 93479-97-1 (Glimepiride )

  • CAS No:93479-97-1
  • Molecular Weight: 490.62
  • Molecular Formula: C24H34N4O5S
Properties Safety and Handling MSDS NMR Spectrum Synthesis Route Precursor and Product
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Glimepiride (Related Reference)
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Precursor and Product
References of Glimepiride cas 93479-97-1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 28ug/kg/2D-I (0.028mg/kg) BLOOD: HEMORRHAGE
BLOOD: THROMBOCYTOPENIA
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Annals of Pharmacotherpy. Vol. 34, Pg. 120, 2000.
mouse LD50 unreported > 10gm/kg (10000mg/kg) ? Diabetes Frontier. Vol. 3, Pg. 565, 1992.
rat LD intraperitoneal > 3950mg/kg (3950mg/kg) LIVER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 547, 1993.
rat LD oral > 10gm/kg (10000mg/kg) LIVER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 547, 1993.
rat LD50 unreported > 10gm/kg (10000mg/kg) ? Diabetes Frontier. Vol. 3, Pg. 565, 1992.

Safety

Hazard Codes:?HarmfulXn,IrritantXi
Risk Statements: 21-36/38-46-62-63?
R21:Harmful in contact with skin.?
R36/38:Irritating to eyes and skin.?
R46:May cause heritable genetic damage.?
R62:Risk of impaired fertility.?
R63:Possible risk of harm to the unborn child.
Safety Statements: 25-26-36/37-53
S25:Avoid contact with eyes.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37:Wear suitable protective clothing and gloves.?
S53:Avoid exposure - obtain special instructions before use.
WGK Germany: 3
RTECS: UX9363950