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Home> CAS DataBase Listed 9 > CAS 99300-78-4
Identification of 99300-78-4
  • Name:
  • Venlafaxine hydrochloride (Related Reference)
  • Synonyms:
  • 1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol; Cyclohexanol,1-[2-(dimethylamino)-1-(4- methoxyphenyl)ethyl]-,hydrochloride; Venlafaxina [INN-Spanish]; venlafaxine HCl; Effexor XR; Elafax; Venlafaxine hydrochloride (JAN/USAN); Effexor (TN); Cyclohexanol, 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, hydrochloride; Venlafaxine Hydrochlorid; Venlafaxin HCL; Wy-45030; Effexor; Wy-45,030; Venlafaxinum [INN-Latin]; (+-)-1-(alpha-((Dimethylamino)methyl)-p-methoxybenzyl)cyclohexanol hydrochloride; N,N-dimethyl-2-p-methoxy- phenyl-2-(1-hydroxycyclohexyl) ethylamine hyd- rochloride;
  • This structure is also available as a 2d Mol file
Safety Data of 99300-78-4 Properties of 99300-78-4
  • Appearance:
  • white crystalline powder
  • Molecular Weight:
  • 277.40178
  • Density:
  • 1.394 g/cm3
  • Boiling Point:
  • 397.6 °C at 760 mmHg
  • Melting Point:
  • 207-209 °C
  • Flash Point:
  • 194.2 °C
  • Solubility:
  • Soluble
  • Biological Activity:
  • Dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (K i values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.
  • Usage:
  •  Venlafaxine hydrochloride (CAS NO.99300-78-4) can be used as a selective serotonin noradrenaline reuptake inhibitor and also used as an antidepressant. And, it is used primarily for the treatment of major depression in adults.

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CAS No. 99300-78-4 (Venlafaxine hydrochloride )

  • CAS No:99300-78-4
  • Molecular Weight: 277.40178
  • Molecular Formula: C17H28ClNO2
Properties Safety and Handling MSDS NMR Spectrum Synthesis Route Precursor and Product
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Precursor and Product
References of Venlafaxine hydrochloride cas 99300-78-4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 1071ug/kg (1.071mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER
Journal of Toxicology, Clinical Toxicology. Vol. 35, Pg. 211, 1997.
man TDLo oral 32mg/kg/9W-I (32mg/kg) BEHAVIORAL: HEADACHE

BEHAVIORAL: WITHDRAWAL
Medical Journal of Australia. Vol. 169, Pg. 91, 1998.
women LDLo oral 168mg/kg (168mg/kg) BEHAVIORAL: COMA

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Medical Journal of Australia. Vol. 169, Pg. 445, 1998.
women LDLo oral 235mg/kg/12D- (235mg/kg) LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"

GASTROINTESTINAL: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Journal of Analytical Toxicology. Vol. 20, Pg. 266, 1996.
women TDLo oral 94500ug/kg/9W (94.5mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER
Annals of Pharmacotherpy. Vol. 33, Pg. 1009, 1999.
women TDLo oral 315mg/kg/30W- (315mg/kg) BEHAVIORAL: WITHDRAWAL

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
Medical Journal of Australia. Vol. 169, Pg. 91, 1998.
women TDLo oral 360mg/kg/17W- (360mg/kg) BEHAVIORAL: WITHDRAWAL

SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Medical Journal of Australia. Vol. 169, Pg. 91, 1998.
?

Safety

Hazard Codes:?IrritantXi
Risk Statements 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S37/39:Wear suitable gloves and eye/face protection.

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