Synonyms: (2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-Methyl 4a,6a-diMethyl-2,4'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate; Eplerenone [USAN]; Eplerenone for system suitability; Eplerenone intermediate Eplerenone; HSDB 7522; plerenone;
White SolidEplerenone derives its antihypertensive effect by blocking the binding of aldosteroneat the mineralocorticoid receptor (MR). The drug, which was previously approvedonly for the oral treatment of hypertension, is now indicated to improve survival ofstable patients with left ventricular systolic dysfunction (ejection fraction ＜40%) andclinical evidence congestive heart failure (CHF) after an acute myocardial infarction.
Pharmacology and Side Effects of Eplerenone Aldosterone, the final product of the renin-angiotensin-aldosterone system (RAAS), is a mineralocorticoid hormone that classically acts, via the mineralocorticoid (aldosterone) receptor, on epithelia of the kidneys, colon, and sweat glands to maintain electrolyte homeostasis. Aldosterone has also b...more+May 17 2021
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