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Home> Products > Other Chemicals > Others > CAS DataBase Listed 1 > CAS 1193383-09-3
1193383-09-3 structure 3D

CAS 1193383-09-3 products price,suppliers

  • Name: Copper, tetrakis[m-[2-hydroxy-3,5-bis(1-methylethyl)benzoato-kO:kO']]di-, (Cu-Cu), hydrate (9CI)
  • Molecular Weight: 346.65
  • Formula: C15H15CLN6OS
  • Synonyms: 1-(5-Chloro-6-(trifluoromethoxy)-1H-benzo[d]imidazol-2-yl)-1H-pyrazole-4-carboxylic acid; 1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid; 1-[6-Chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]-1H-pyrazole-4-carboxylic acid; 1H-Pyrazole-4-carboxylic acid, 1-[6-chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]-; CS-1577; HIF-PHD Inhibitor II;
  • Hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) enzymes act as central gatekeepers of posttranscriptional and transcriptional adaptation to hypoxia, oxidative stress, and excitotoxicity. Their catalytic activity is dependent on iron, 2-oxoglutarate (2-OG), and oxygen, and leads to the stabilization of a host of proteins, including the hypoxia-inducible transcription factors in response to oxygen availability. Inhibitors of PHD have been used to mimic a hypoxic response in order to study a range of oxygen-deprivation-related disorders, including anemia, ulcerative colitis, myocardial ischemia, stroke, and metabolic disorders. JNJ-42041935 is a selective, 2-OG competitive, and reversible inhibitor of PHD enzymes (pKis = 7.91, 7.29, and 7.65 for PHD1, 2, and 3, respectively). It is >100-fold selective for PHD compared to the related FIH (factor-inhibiting HIF) and a panel of various other enzymes. In an inflammation-induced anemia model in rats, 100 μM/kg/day JNJ-42041935 significantly increased the number of circulating reticulocytes and red blood cells, increased blood hemoglobin and hematocrit, and restored mean corpuscular volume and mean cell hemoglobin of red bloods cells.[Cayman Chemical] 1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acidSupplier
Properties Safety and Handling MSDS Computational chemical data
Identification Safety Data
Properties
  • Molecular Weight:
  • 346.65
  • Density:
  • 0.79
  • Boiling Point:
  • 576.4°Cat760mmHg
  • Flash Point:
  • 379.5°C
  • More Properties>>
There are 8 suppliers who can provide Copper, tetrakis[m-[2-hydroxy-3,5-bis(1-methylethyl)benzoato-kO:kO']]di-, (Cu-Cu), hydrate (9CI) with CAS No. 1193383-09-3
1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid
1-(6-chloro-5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyr...
  • FOB Price:1 USD/Gram 
  • Min.Order:1kg Kilogram 
  • Supply Ability:1000 Metric Ton/Day 
  • Appearance:COA 
  • Purity:99% 
  • Packaging:1KG/BAG 
  • Usage:For Medical research 
  • Brand:CLAP 
  • Description:Pls feel free to contact us for detailed product specifications, product tech. date sheet, COA and MSDS, prices, delivery time and payment terms.
  • Updatetime:Dec 26 2020 
JNJ-42041935
JNJ-42041935
  • Purity:95% 
  • Packaging:according to customer’s requirement 
  • Description:Superiority we promise quality; we deliver goods timely; we test product purity before delivery;we quote price reasonabl;we guarantee after sale service. Details Transportation:FEDEX/DHL/TNT/By Sea / By Air Storage:2-8℃ Keywords:JNJ-42041935 fast delivery,JNJ...
  • Updatetime:Feb 26 2019 
JNJ-42041935
JNJ-42041935
  • Min.Order:1 Gram 
  • Supply Ability:10 Kilogram/Month 
  • Appearance:Solid powder 
  • Purity:98% 
  • Description:Superiority jnj-42041935 is a potent (pk(i) = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of phd enzymes. jnj-42041935 is a new pharmacological tool, which can investigate phd inhibition and demonstrate that phd inhibitors offer g...
  • Updatetime:Feb 26 2019 
JNJ-42041935
JNJ-42041935
  • Purity:98.0% 
  • Packaging:10g, 100g,1kg, 5kg, 10kg, 7783kg 
  • Description:Superiority 1.we are specializing in providing customers with complete chemical raw materials. 2.superior quality, moderate price & quick delivery. 3. extensive international cooperation experience. 7688. outstanding communication skills. Details pharmaceutica...
  • Updatetime:Feb 25 2019 
1-[6-chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]pyrazole-4-carboxylic acid
1-[6-chloro-5-(trifluoromethoxy)-1H-benzimidazol-2-yl]pyrazole-4-carboxylic acid
JNJ-42041935
JNJ-42041935
  • Updatetime:Nov 25 2019 
JNJ-42041935
JNJ-42041935
  • Updatetime:Nov 25 2019 
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