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Home> Products > Other Chemicals > Others > CAS DataBase Listed 1 > CAS 130112-42-4
130112-42-4 structure 3D

CAS 130112-42-4 products price,suppliers

  • Mivotilate is an orally-active hepatoprotective agent introduced for the treatment of liver cirrhosis and hepatitis-B infection. It is adithietanylidene malonate analogue of malotilate and is without thehaemotological adverse effects associated with the latter. Mivotilate can beobtained by partial saponification of the corresponding diisopropylmalonate,conversion of the acid function into mixed anhydride then to the amide with anaminothiazole. It displays potent hepatoprotective activity in rat and mice liverinjury models by a mechanism involving the inactivation of Kupffer cells.Mivotilate was shown to exert multiple effects on the hepatic cytochrome P450system, particularly to inhibit CYP2E1 expression and to up-regulate theCYP1A1 expression. The low oral bioavailability of Mivotilate in rats (F<0.22%)could be primarilly attributed to poor absorption and considerable hepatic andgastrointestinal first-pass effects. Mivotilate prevents mutagenesis caused byagents such as benzo[a]pyrene and reduces skin tumors induced by theseagents.
  • Name: 3-[(4-chlorophenyl)sulfonyl]-1-hexyl-2-imino-10-methyl-1,2-dihydro-5h-dipyrido[1,2-a:2',3'-d]pyrimidin-5-one
  • Molecular Weight: 330.44616
  • Formula: C18H15F3N2O2S2
  • Synonyms: 1,3-Dithietane, propanoic acid deriv.; 1-Methylethyl 2-(1,3-dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxopropanoate; 2-(1,3-Dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-propanoic acid 1-methylethyl ester; Ccris 8109; Isopropyl 2-(1,3-dithietane-2-ylidine)-2-(N-(4-methyl-2-thiazol-2-yl)carbamoyl)acetate; Isopropyl-2-(1,3-dithietane-2-ylidene)-2[N-(4-methyl2-thiazol-2-yl)carbamoyl] acetate;
Properties Safety and Handling MSDS Computational chemical data
Safety Data
  • Molecular Weight:
  • 330.44616
  • Density:
  • 1.312±0.06 g/cm3(Predicted)
  • Refractive index:
  • 1.68
  • More Properties>>
There are 3 suppliers who can provide 3-[(4-chlorophenyl)sulfonyl]-1-hexyl-2-imino-10-methyl-1,2-dihydro-5h-dipyrido[1,2-a:2',3'-d]pyrimidin-5-one with CAS No. 130112-42-4
Propanoic acid,2-(1,3-dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-,1-methylethyl ester
2-(1,3-Dithietan-2-ylidene)-2-[N-(4-methylthiazol-2-yl)carbamoyl]acetic acid isopropyl ester
  • Description:2-(1,3-Dithietan-2-ylidene)-2-[N-(4-methylthiazol-2-yl)carbamoyl]acetic acid isopropyl ester
  • Updatetime:Apr 25 2014 
  • Updatetime:Nov 26 2019 
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