CAS 130112-42-4 products price,suppliers

Mivotilate is an orally-active hepatoprotective agent introduced for the treatment of liver cirrhosis and hepatitis-B infection. It is adithietanylidene malonate analogue of malotilate and is without thehaemotological adverse effects associated with the latter. Mivotilate can beobtained by partial saponification of the corresponding diisopropylmalonate,conversion of the acid function into mixed anhydride then to the amide with anaminothiazole. It displays potent hepatoprotective activity in rat and mice liverinjury models by a mechanism involving the inactivation of Kupffer cells.Mivotilate was shown to exert multiple effects on the hepatic cytochrome P450system, particularly to inhibit CYP2E1 expression and to up-regulate theCYP1A1 expression. The low oral bioavailability of Mivotilate in rats (F<0.22%)could be primarilly attributed to poor absorption and considerable hepatic andgastrointestinal first-pass effects. Mivotilate prevents mutagenesis caused byagents such as benzo[a]pyrene and reduces skin tumors induced by theseagents.

Name: 3-[(4-chlorophenyl)sulfonyl]-1-hexyl-2-imino-10-methyl-1,2-dihydro-5h-dipyrido[1,2-a:2',3'-d]pyrimidin-5-one
Molecular Weight: 330.44616
Formula: C_₁₈H_₁₅F_₃N_₂O_₂S_₂
Synonyms: 1,3-Dithietane, propanoic acid deriv.; 1-Methylethyl 2-(1,3-dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxopropanoate; 2-(1,3-Dithietan-2-ylidene)-3-[(4-methyl-2-thiazolyl)amino]-3-oxo-propanoic acid 1-methylethyl ester; Ccris 8109; Isopropyl 2-(1,3-dithietane-2-ylidine)-2-(N-(4-methyl-2-thiazol-2-yl)carbamoyl)acetate; Isopropyl-2-(1,3-dithietane-2-ylidene)-2[N-(4-methyl2-thiazol-2-yl)carbamoyl] acetate;

Properties Safety and Handling MSDS Computational chemical data

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Identification

Cas NO.:130112-42-4
CID:148185
Name:
3-[(4-chlorophenyl)sulfonyl]-1-hexyl-2-imino-10-methyl-1,2-dihydro-5h-dipyrido[1,2-a:2',3'-d]pyrimidin-5-one (Related Reference)
InChI:
InChI=1S/C12H14N2O3S3/c1-6(2)17-10(16)8(11-19-5-20-11)9(15)14-12-13-7(3)4-18-12/h4,6H,5H2,1-3H3,(H,13,14,15)
This structure is also available as a 2d Mol file

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Properties

Molecular Weight:
330.44616
Density:
1.312±0.06 g/cm3(Predicted)
Refractive index:
1.68
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