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Home> Products > Organic Intermediates > Pharmaceutical Intermediates > CAS DataBase Listed 1 > CAS 14484-47-0
14484-47-0 structure

CAS 14484-47-0 Deflazacort products price,suppliers

  • Acetone-hexane, m.p. 255-256.5 ℃. [Α] D + 62.3 ° (C = 0.5, chloroform). UV absorption maximum (methanol): 241~242nm (E1cm1% 352.5). Acute toxicity LD50 in mice (mg/kg): 5200 oral; 1610 subcutaneous injection. Rats Acute toxicity LD50 (mg/kg): 109 subcutaneously. Dog Acute toxicity LD50 (mg/kg):> 4000 Oral; 50 subcutaneous injection. Off-White to Pale Yellow SolidDeflazacort (trade name Emflaza among others) is a glucocorticoid used as an anti-inflammatory and immunosuppressant. It belongs to a


    Deflazacort is a corticosteroid hormone.|Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA. Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dystrophin gene, which is important for muscle function. This disease can cause serious muscle weakness and progressive breathing and cardiovascular disability, severely impacting patient quality of life and survival. This disease usually manifests by muscle weakness in early childhood followed by loss of the ability to walk (ambulation) as early as age 7. Deflazacort delays the onset of muscle related complications resulting from DMD, prolonging the lives of children diagnosed with this disease and exerting less harmful effects on the bone health and weight than other steroid medications.|Deflazacort is a Corticosteroid. The mechanism of action of deflazacort is as a Corticosteroid Hormone Receptor Agonist.|Deflazacort is a synthetic glucocorticoid prodrug, with anti-inflammatory and immunomodulating properties. Upon administration, the active metabolite of deflazacort, 21-desacetyl deflazacort, binds to and activates tissue glucocorticoid receptors. This results in the inhibition of specific leukocyte functions and the inhibition of proinflammatory cytokine production.

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  • Name: Deflazacort
  • Molecular Weight: 441.52
  • Formula: C25H31NO6
  • Synonyms: (11b,16b)-21-(Acetyloxy)-11-hydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione; (5'β)-11β-Hydroxy-21-acetyloxy-2'-methyl-1,2,4,5-tetradehydropregnano[17,16-d]oxazole-3,20-dione; (5'β)-21-Acetyloxy-11β-hydroxy-2'-methylpregnano[17,16-d]oxazole-1,4-diene-3,20-dione; 11b,21-Dihydroxy-2'-; 11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate; 16-d)oxazole-3,20-dione,11-beta,21-dihydroxy-2’-5’-beta-h-pregna-4-dieno(17;
Properties Safety and Handling MSDS NMR Spectrum Synthesis Route Precursor and Product Computational chemical data
Identification
  • Cas NO.:14484-47-0
  • CID:189821
  • Name:
  • Deflazacort (Related Reference)
  • EINECS:
  • 238-483-7
  • InChI:
  • InChI=1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3/t17-,18-,19-,21+,22+,23-,24-,25+/m0/s1
Safety Data
  • [Risk Codes]
  • [Safety Statements]
Properties
  • Molecular Weight:
  • 441.52
  • Density:
  • 1.41
  • Boiling Point:
  • 544.2 °C at 760 mmHg
  • Melting Point:
  • 255-256.5°C
  • Flash Point:
  • 282.9 °C
  • Alpha:
  • D +62.3° (c = 0.5 in chloroform)
  • Storage Temperature:
  • 2-8°C
  • Refractive index:
  • 1.675
  • Solubility:
  • DMSO: ≥20mg/mL
  • More Properties>>
Upstream Product Downtream information
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Deflazacort CAS 14484-47-0
Deflazacort CAS 14484-47-0
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Deflazacort CAS 14484-47-0
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  • Description:Product Description Density 1.4±0.1 g/cm3 Boiling Point 595.4±50.0 °C at 760 mmHg Melting Point 255-256.5ºC Molecular Formula C25H31NO6 Molecular Weight 441.517 Flash Point 313.9±30.1 °C Exact Mass 441.215149
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DeflazacortCAS NO.: 14484-47-0
DeflazacortCAS NO.: 14484-47-0
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11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate
11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,...
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  • Usage:A systemic corticosteroid. A derivative of prednisolone. Used for rheumatoid arthritis and 
  • Brand:royals 
  • Description:11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate Appearance: COA Molecular Weight: 441.52 Density: 1.41 g/cm3 Boiling Point: 595.4 oC at 760 mmHg Melting Point: 255-256.5oC Flash Point: 313.9oC Solubility: 3.4 mg/L (25 C) ...
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Deflazacort 14484-47-0 manufacturer/low price/high quality/in stock
Deflazacort 14484-47-0 manufacturer/low price/high quality/i...
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  • Description:16-d)oxazole-3,20-dione,11-beta,21-dihydroxy-2’-5’-beta-h-pregna-4-dieno(17;azacort;calcort;deflan;(5'β)-11β-Hydroxy-21-acetyloxy-2'-methyl-1,2,4,5-tetradehydropregnano[17,16-d]oxazole-3,20-dione;
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CAS:14484-47-0 Deflazacort
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Deflazacort
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  • Description:Name: Deflazacort Synonyms: deflan; Dezacor; azacort; calcort; Lantadin; DL 458-IT; Flantadin; Denazacort; EINECS 238-483-7; 11b,21-Dihydroxy-2'-; Cortax,Decortil,Deflanil; 16-d)oxazole-3,20-dione,11-beta,21-dihydroxy-2’-5’-beta-h-pregna-4-dieno(17; Pregna-1...
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  • Description:Product name: Deflazacort Synonyms: 11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate CAS: 14484-47-0 Molecular Formula: C25H31NO
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Deflazacort
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  • Description:Name: Deflazacort Synonyms: (11b,16b)-21-(Acetyloxy)-11-hydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione; (5'β)-11β-Hydroxy-21-acetyloxy-2'-methyl-1,2,4,5-tetradehydropregnano[17,16-d]oxazole-3,20-dione; (5'β)-21-Acetyloxy-11β-hydroxy-2'-m...
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11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate
11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxa...
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  • Description:Name:11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate;CAS No.:14484-47-0;Appearance:White crystalline powder;Assay:≥97%.;Brief Introduction:intermediates, drug discovery
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Deflazacort
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  • Description:Name: Deflazacort Synonyms: H894; D4523; s1888; Zamene; D03671; Cortax; l-5458; deflan; calcort; azacort; Emflaza; KS-1158; CS-2349; 484D470; MDL-458; RL01810; Dezacor; MDL 458; DB11921; C-22370; Deflanil; Enzocort; HY-13609; Decortil; DL-458IT; CC-26308; Q-10...
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Deflazacort
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Deflazacort CAS 14484-47-0
Deflazacort CAS 14484-47-0
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