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Home> Products > Organic Intermediates > Agrochemical Intermediates > CAS DataBase Listed 1 > CAS 1481-32-9
1481-32-9 structure

CAS 1481-32-9 6-Fluoro-1-indanone | Products & Prices & Suppliers

  • AlCl3-(4-Fluoro-phenyl)-propionic acid (5 g, 29.7 mmol; Compound E in FIG. 7) was added to polyphosphoric acid (PPA; 65.4 g, 0.654 mol) at 50° C. The viscous mixture was heated at 90° C. for 2 hours. The syrup was poured into ice water and stirred for 30 minutes. The aqueous mixture was extracted with ether (3.x.50 mL) and the combined organics were washed with HExample 150: (+/-)-3-[5-Chloro-2-(6-fluoro-indan-1 -yloxy)-phenoxy1-azetidine.; Step A: Preparation of (+/-)-6-fluoro-indan-1-ol.; To a solution of 6-fluoro- indan-1 -one (0.50 g, 3.3 mmol) in DCE (10 ml_) and MeOH (10 ml_) was added NaBH4 (0.25 g, 6.6 mmol). After 30 min the reaction was quenched with H2O (10 ml_) and extracted with CH2CI2 (3 x 20 ml_). The organic layers were combined and dried to give the title compound (0.49 g, 97%). MS (ESI): mass calcd. for C9H7FO, 150.1 ; m/z found, 151.4 [M+H]+. 1H NMR (CDCI3): 7.23 - 7.13 (m, 1 H), 7.09 (dd, J = 8.6, 2.5 Hz, 1 H), 6.99 - 6.90 (m, 1 H), 5.21 (t, J = 6.3 Hz, 1 H), 3.13 - 2.91 (m, 1 H), 2.85 - 2.68 (m, 1 H), 2.63 - 2.44 (m, 1 H), 2.09 - 1.74 (m, 2H).General procedure: NaBH4 (1.49 g, 39.3 mmol) was added to a solution of 6-methoxyindan-1-one (5.50 g, 33.9 mmol) in MeOH (100 mL) and stirred for 90 min at r.t. The reaction was quenched with H2O (400 mL) and themixture stirred for 15 min. The resulting mixture was extracted with Et2O (3 × 150 mL). The combined extracts were dried (MgSO4), filteredand concentrated to afford 6-methoxyindan-1-ol (5.82 g, quantitative yield) as a yellow oil.To a solution of A solution of the indanone (Compound F in FIG. 7; 2.06 g, 13.7 mmol) and ethyl bromoacetate (EBA; 3.44 g, 20.6 mmol) in benzene (10 mL) was added over a 5 minute period to activated zinc (3.77 g, 57.7 mmol) in benzene (21 mL) and ether (10 mL). A few crystals of iodine were added to initiate the reaction and the mixture was held at reflux. At 3 hour intervals, 2 batches of zinc (1.8 g, 27.5 mmol) and ethyl bromoacetate (EBA; 1.8 g, 10.8 mmol) were added and the mixture was refluxed overnight. The solution was cooled to room temperature and ethanol (5 mL) and acetic acid (23 mL) were added. The solution was poured into 1:1 aqueous acetic acid (100 mL) and the organic layer was separated. The aqueous phase was extracted with diethyl ether (Et2O; 2×25 mL) and the combined organics were washed with water, NaHCO3, water, dried (MgSO4), filtered, and concentrated in vacuo to give the crude product (Compound G in FIG. 7; 3.55 g).General procedure: To a solution of LDA or LHMDS (48.0 mmol, 2.0 equiv) in anhydrous THF (100 mL) was added EtOAc (61.0 mmol, 2.5 equiv) at -78 C. The mixture was stirred at -78 C for 30 min. To the resulting mixture was added dropwise a solution of indenone (24.0 mmol, 1.0 equiv) in anhydrous THF (20 mL). The mixture was stirred at -78 C for another 4 h and then quenched with a saturated aqueous NH4Cl. The mixture was extracted with EtOAc (20 mL × 3). The combined organic layers were dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. To the residue was added HOAc/ H2SO4 (10/1, 40 mL). After stirring for 4 h at room temperature, the mixture was extracted with EtOAc (15 mL × 3). The combined extracts were washed successively with water, saturated NaHCO3, and brine, dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel to afford inden-3-yl acetate.3-(4-Fluoro-phenyl)-propionic acid (5 g, 29.7 mmol; Compound E in FIG. 7) was added to polyphosphoric acid (PPA; 65.4 g, 0.654 mol) at 50 C. The viscous mixture was heated at 90 C. for 2 hours. The syrup was poured into ice water and stirred for 30 minutes. The aqueous mixture was extracted with ether (3×50 mL) and the combined organics were washed with H2O (2×50 mL) and NaHCO3 until neutralized. The resulting organic phase was washed with H2O (50 mL), dried (MgSO4), filtered, and concentrated in vacuo. Purification using flash chromatography (7:1 hexane/ethyl acetate (EtOAc)) afforded the indanone (Compound F in FIG. 7) as a yellow solid (2.06 g, 46%). 1H NMR (CDCl3) delta 7.45 (ddd, J=0.5, 4.5, 8.4 Hz, 1H), 7.39 (ddd, J=0.3, 2.6, 7.8 Hz, 1H), 7.30 (td, J=2.6, 8.6 Hz, 1H), 3.12 (t, J=5.7 Hz, 2H), 2.75 (m, 2H); ESI-CID 151 (M-H+).A mixture of 3-(4-fluorophenyl)propionic acid (20.0 g) and polyphosphoric acid (800 g) was stirred and heated at 100 C. for 2 hr. The mixture was then poured into an ice/water mixture (1 kg) and extracted with ethyl acetate. The organic phase was washed with water, dilute sodium bicarbonate solution and water again, then dried (MgSO4) and evaporated to give

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  • Name: 6-Fluoro-1-indanone
  • Molecular Weight: 150.152
  • Formula: C9H7FO
  • Synonyms: 1H-Inden-1-one, 6-fluoro-2,3-dihydro-; 1H-Inden-1-one, 6-fluoro-2,3-dihydro-, compd. with 5-methoxy-2,4-pyrimidinediol (1:1); 6-Fluor-2,3-dihydro-1H-inden-1-on; 6-Fluorindan-1-on; 6-Fluoro-1-indanone - 5-methoxy-2,4-pyrimidinediol (1:1); 6-Fluoro-1-indenone;
Properties Safety and Handling MSDS Synthesis Route Precursor and Product Computational chemical data
Safety Data
  • [Risk Codes]
  • R22:Harmful if swallowed
  • [Safety Statements]
  • S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
  • S36:Wear suitable protective clothing
  • Hazard Symbols:
  • HazardClass:IRRITANT
  • Molecular Weight:
  • 150.152
  • Density:
  • 600.5
  • Boiling Point:
  • 60 °C
  • Melting Point:
  • 56-60℃
  • Flash Point:
  • 29.9°C
  • Refractive index:
  • 1.367
  • More Properties>>
Question & Answer
  • How to Synthesize 6-Fluoro-1-indanone? Background and Overview[1] 6-Fluoro-1-indanone is a pharmaceutical intermediate that can be synthesized from p-fluorocinnamic acid. The first step involves the preparation of 3-(4-fluorophenyl)propion..more+ Jul 13 2020
Upstream Product Downtream information
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  • Description:Amitychem Corporation manufacture and supply 6-Fluoro-1-indanone with high quality, low price and bulk supply. We have been focusing on the research and production of concrete chemicals for 14+ years. Our product quality has ISO, SGS, CQC,FAMI-QS, etc. Cetific...
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  • Description:6-Fluoro-1-indanone Basic information Product Name: 6-Fluoro-1-indanone CAS: 1481-32-9
  • Updatetime:Jul 07 2023 
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  • Description:Name: 1H-Inden-1-one,6-fluoro-2,3-dihydro- Synonyms: 1-Indanone,6-fluoro- (6CI,7CI,8CI); CAS Registry number: 1481-32-9 EINECS:-0 Molecular Formula: C9H7FO Boiling Point: 60 °C Flash Point: 29.9°C Density: 600.5 Appearance: white to light yellow crystal powde...
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  • Description:Product name 6-Fluoro-1-indanone Synonyms 6-Fluoro-1-indanone CAS No. 1481-32-9 Molecular Formula C9H7FO Molecular Weight 150.15 Appearance white powder Assay 98% Application Used as Pharmaceutical intermediates Packing as required
  • Updatetime:Sep 21 2023 
  • Min.Order:1 Kilogram 
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  • Purity:99 
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  • Description:Trimeric sodium phosphate detergent auxiliary agent is a kind of excellent properties, is one of the biggest component of detergent consumption during the production, it has four aspects: 1, chelation of heavy metal ions, heavy metal ions in the water in the w...
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  • Description:Shanghai Credit Asia Chemical Co., Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.We will provide you with better service, better quality, better pri...
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  • Brand:Rlavie 
  • Description:Density 1.3±0.1 g/cm3
  • Updatetime:Apr 28 2022 
  • Appearance:contact us for more details about 6-Fluoro-1-indanone, CAS:1481-32-9 
  • Purity:contact us for more details about 6-Fluoro-1-indanone, CAS:1481-32-9 
  • Packaging:Glass bottle in aluminum foil bag, from mg scale to kg scale 
  • Usage:Chemicals, pharmaceutical research, pharmaceutical intermediates, reagents 
  • Brand:FINETECH 
  • Description:FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the 6-Fluoro-1-indanone, CAS:1481-32-9 with the most competitive price and the best quality. We can...
  • Updatetime:Nov 21 2018 
  • Min.Order:1 Kilogram 
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  • Purity:0.98 
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  • Description:Name: 1H-Inden-1-one,6-fluoro-2,3-dihydro- (Related Reference) EINECS: -0 Molecular Formula: C9H7FO CAS Registry Number: 1481-32-9 Synonyms: 1-Indanone,6-fluoro- (6CI,7CI,8CI); InChI: InChI=1/C5H10ClF3Si/c1-10(2,6)4-3-5(7,8)9/h3-4H2,1-2H3
  • Updatetime:Nov 29 2022 
  • Min.Order:1 Gram 
  • Purity:98.00% 
  • Packaging:Clients requirement 
  • Usage:Pharmaceutical intermediates 
  • Brand:Isen 
  • Description:【Appearance】 white to light yellow crystal powder【Density】 600.5【Melting Point】 56-60℃【Boiling Point】 60 °C【Vapour】 14.5mmHg at 25°C【Refractive Index】 1.367【Flash Point】 29.9°C
  • Updatetime:May 26 2022 
  • Min.Order:0.1 Kilogram 
  • Purity:98% 
  • Packaging:According to the customer's requirements 
  • Description:Notes: For more information and products, please feel free to contact our sales department about your inquiries. Claim: Products are sold only to countries where patents are not infringed. Customers are responsible for their own obligations.
  • Updatetime:Aug 31 2015 
  • Min.Order:1 Kilogram 
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  • Packaging:According to your demand 
  • Description:1-Indanone,6-fluoro- (6CI,7CI,8CI); 6-Fluoro-1-indanone
  • Updatetime:Nov 21 2018 
  • Min.Order:1 Gram 
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  • Purity:98% 
  • Packaging:Aluminum foil bag,or according to your requirements. 
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  • Description:SC-01210
  • Updatetime:Dec 15 2016 
  • Purity:97% 
  • Packaging:According to customer requirements 
  • Description:Pharmaceutical intermediates
  • Updatetime:Jul 26 2023 
  • Purity:99% 
  • Packaging:as requested 
  • Description:off-white solid
  • Updatetime:May 05 2019 
  • Description:Name: 1H-Inden-1-one,6-fluoro-2,3-dihydro- Synonyms: 1-Indanone,6-fluoro- (6CI,7CI,8CI); CAS Registry number: 1481-32-9 EINECS:-0 Molecular Formula: C9H7FO Boiling Point: 60 °C Flash Point: 29.9°C Density: 600.5 Appearance: white to light yellow crystal powde...
  • Updatetime:Jun 12 2019 
  • Updatetime:Nov 26 2019 
  • Updatetime:Nov 21 2018 
  • Updatetime:Nov 13 2010 
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