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3-((5-Amino-6-methylpyridin-2-yl)ethynyl)-7, 7-dimethyl-7, 8-dihydroquinoone[00319] A mixture of 6-methyl-5-nitropyridin-2-ol (500 mg, 3.24 mmol), POCIThe raw material 3 (150 mg) and PCl(c) To 6-Hydroxy-3-nitro-2-picoline (15.73 g, 0.102 mol) was added PCls (5.73 g, 0.027 mol) and POCh (2.9 ml, 0.032 mol). This mixture was heated at 110-115°C for 3 hrs. However, the amount of POCh added was only enough to moisten the starting material. More POC13 (3 ml) was added, the reaction mixture heated at 110-115°C but only sublination of PCls (100°C) was observed. DMF (5 ml) was added and the solution was heated at 115°C for 5 hrs, cooled and poured into a slush of ice and water. A beige product precipitated and the water suspension was stirred for 48 hrs. The brown precipitate was filtered off and washed with water. Purification by dry-flash dichloromethane yielded 10.93 g (62 percent) of 6-chloro-2-picoline.B. To a solution of