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Home> Products > Pharmaceuticals and Biochemicals > Antibiotic and Antimicrobial Agents > CAS DataBase Listed 2 > CAS 224452-66-8
224452-66-8 structure

CAS 224452-66-8 RETAPAMULIN products price,suppliers
  • Antibacterial retapamulin is a derivative of the naturalproduct pleuromutilin and was developed by Glaxo and approvedin the US in 2007 for the treatment of skin infections. It has a unique mechanism of action, inhibiting bacterialprotein synthesis by inhibiting the larger subunit of the ribosome,and thus has no cross resistance to other antibacterialagents.Pleuromutilin is a tricyclic diterpenoid that was first isolated in 1951 from the edible mushroom Pleurotus mutilus. The first semisynthetic analogs tiamulin and valnemulin, developed for veterinary use, have been shown to interact uniquely with bacterial ribosomes by high affinity binding to a site on the 50S subunit. Binding to this site interferes with ribosomal peptidyl transferase activity, blocks P-site interactions, and prevents the evolution of active 50S ribosomal subunits. Retapamulin, the first pleuromutilin approved for human use, behaves similarly to selectively inhibit bacterial protein synthesis. This novel mechanism of action has been implicated in the lack of in vitro target-specific cross-resistance with other classes of antibiotics.
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  • Name: RETAPAMULIN
  • Molecular Weight: 517.76348
  • Formula: C30H47NO4S
  • Synonyms: (1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetraMethyl-9-oxotricyclo[5.4.3.0^{1,8}]tetradecan-6-yl 2-{[(1R,3S,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl]sulfanyl}acetate; (2R,3S,4S,6R,8R)-3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.01,8]tetradec-6-yl {[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]sulfanyl}acetate; (3aS,4R,5S,6S,8R,9R,9aR,10R)-2-(exo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ylsulfanyl)acetic acid 5-hydroxy-4,6,9,10-tetraMethyl-1-oxo-6-vinylperhydro-3a,9-propanocyclopentacycloocten-8-yl ester; Acetic acid, [[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester; Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester; Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (4R,5S,6S,8R,9aR)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester;
Properties Safety and Handling MSDS Synthesis Route Precursor and Product Computational chemical data
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Identification
  • Cas NO.:224452-66-8
  • CID:6918462
  • Name:
  • RETAPAMULIN (Related Reference)
  • InChI:
  • InChI=1S/C30H47NO4S/c1-7-28(4)16-24(35-25(33)17-36-22-14-20-8-9-21(15-22)31(20)6)29(5)18(2)10-12-30(19(3)27(28)34)13-11-23(32)26(29)30/h7,18-22,24,26-27,34H,1,8-17H2,2-6H3/t18-,19+,20-,21+,22?,24-,26+,27+,28-,29+,30+/m1/s1
Safety Data
Properties
  • Molecular Weight:
  • 517.76348
  • Density:
  • 1.16±0.1 g/cm3(Predicted)
  • Boiling Point:
  • 623.8°Cat760mmHg
  • Melting Point:
  • 128-131°C
  • Flash Point:
  • 331°C
  • Refractive index:
  • 1.571
  • Solubility:
  • 3.94e-04 g/L
  • More Properties>>
Upstream Product Downtream information
There are 101 suppliers who can provide RETAPAMULIN with CAS No. 224452-66-8
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Retapamulin
Retapamulin
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  • Description:Product name：Retapamulin CAS：224452-66-8 Molecular Formula：C30H47NO4S Molecular Weight：517.76 Pharmaceutical raw materials；API；Antibiotics；Pharmaceutical intermediates Product name：Retapamu
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Retapamulin
Retapamulin
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Retapamulin
Retapamulin
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Retapamulin
Retapamulin
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  • Description:Name: Acetic acid,2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-,(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-ylester Synonyms: s4056; CR0022; CS-0618; DB01256; MP-0763; 4...
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Retapamulin
Retapamulin
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Mutilin14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)acetate
Mutilin14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)...
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Hot selling Retapamulin CAS NO.224452-66-8
Hot selling Retapamulin CAS NO.224452-66-8
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  • Description:Quick Details Common Name Retapamulin CAS Number 224452-66-8 Molecular Weight 517.763 Density 1.2±0.1 g/cm3 Boiling Point
  • Updatetime:Nov 25 2022 
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RETAPAMULIN
RETAPAMULIN
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  • Description:Product Description R&D, intermediates. Packing&Delivery package:1kg
  • Updatetime:Nov 15 2022 
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Retapamulin
Retapamulin
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Acetic acid
Acetic acid
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High quality Yellow Petroleum Jelly supplier in China
High quality Yellow Petroleum Jelly supplier in China
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  • Brand:Chemzhongyuan 
  • Description:Name: Acetic acid,2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-,(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-ylester Synonyms: Altabax; Altargo; SB275833; Mutilin14-(exo-...
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RETAPAMULIN 224452-66-8 supplier
RETAPAMULIN 224452-66-8 supplier
  • Min.Order:1 Milligram 
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RETAPAMULIN
RETAPAMULIN
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  • Description:Superiority product name :retapamulin product cas:224452-66-8 purity:more than 99% appearance :white powder storage:2kg in store Details product name :RETAPAMULIN product cas:224452-66-8 purity:more than 99% appearance :white powder storage:2kg in store Molecu...
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Acetic acid,2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-,(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-ylester
Acetic acid,2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl...
  • Min.Order:1 Kilogram 
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  • Description:Aceticacid, [[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-,(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-ylester (9CI); Altabax; Altargo; Mutilin14-(exo-8-methyl-8-azabicyclo...
  • Updatetime:Nov 21 2018 
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RETAPAMULIN
RETAPAMULIN
  • FOB Price:0 USD/kilogram 
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  • Updatetime:Mar 01 2017 
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Retapamulin
Retapamulin
  • Purity:95% 
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High Quality Retapamulin 224452-66-8 in stock fast delivery good supplier
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Retapamulin 224452-66-8
Retapamulin 224452-66-8
  • Min.Order:1 Gram 
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  • Updatetime:Dec 10 2015 
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Retapamulin
Retapamulin
  • Description:Zhejiang Kaili Industrial Co., Ltd. is collect Science, Industrial and Trade together for a comprehensive high-tech entities. We are mainly engaged in the research, development, production and sales of APIs and pharmaceutical intermediates.
  • Updatetime:Apr 01 2019 
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RETAPAMULIN
RETAPAMULIN
  • Purity:99% 
  • Packaging:as requested 
  • Description:RETAPAMULIN
  • Updatetime:May 05 2019 
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Related Categories
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