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Home> Products > Organic Intermediates > Organic Intermediate > CAS DataBase Listed 2 > CAS 231291-22-8
231291-22-8 structure

CAS 231291-22-8 6-(Trifluoromethyl)nicotinic acid | Products & Prices & Suppliers

  • In a 10L three-necked flask was charged water 1420g, sulfuric acid 2440g, glacial acetic acid 150mL slowly added 6- (trifluoromethyl) nicotinonitrile 870g (5mol).Reflux overnight reaction.Cool, add ice and cool with ice-brine to precipitate a white solid.The filtrate was extracted with ethyl acetate. The organic phases were combined, washed twice with water and the organic phase was dried to dryness and acid-washed to give 930 g of 6-(trifluoromethyl)-3-picolinic acid as a beige solid. The yield was 97.3percent.In a 10 L three-necked flask, 1420 g of water, 2440 g of sulfuric acid and 150 mL of glacial acetic acid were added, and 870 g (5 mol) of 6- (trifluoromethyl) nicotinonitrile was added slowly.Reflux overnight reaction. Cooling, adding ice cubes, and cooling with ice brine, precipitating a white solid was filtered, the filtrate was extracted with ethyl acetate, the organic phases were combined, washed twice with water, the organic phase was dried and swirled, The residue was acid washed to give 930 g of 5- (trifluoromethyl) picolinic acid as an off-white solid in a yield of 97.3percent.In a 10 L three-necked flask, 1420 g of water, 2440 g of sulfuric acid, and 150 mL of glacial acetic acid were added, and 870 g (5 mol) of 6-(trifluoromethyl)nicotinonitrile was slowly added thereto.The reaction was refluxed overnight.The temperature was lowered, ice was added, and cooled with iced brine to precipitate a white solid.After filtration, the filtrate was extracted with ethyl acetate. The organic phases were combined and washed twice with water. The organic phase was dried by rotary evaporation and the acid eluted to give 930 g of 6-(trifluoromethyl)picolinic acid as an off-white solid. The yield was 97.3percent.

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  • Name: 6-(Trifluoromethyl)nicotinic acid
  • Molecular Weight: 191.109
  • Formula: C7H4F3NO2
  • Synonyms: 2-(trifluoromethyl)pyridine-5-carboxylic acid; 2-TRIFLUOROMETHYL-5-PYRIDINECARBOXYLIC ACID; 3-Pyridinecarboxylic acid, 6-(trifluoromethyl)-; 3-Pyridinecarboxylicacid, 6-(trifluoroMethyl)-; 6- threefluorine Methylnicotinate; 6-(Trifluoromethyl)-3-pyridinecarboxylic acid;
Properties Safety and Handling MSDS Synthesis Route Precursor and Product Computational chemical data
Safety Data
  • [Risk Codes]
  • R36/37/38:Irritating to eyes, respiratory system and skin
  • [Safety Statements]
  • S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
  • S36:Wear suitable protective clothing
  • Hazard Symbols:
  • HazardClass:IRRITANT
  • Molecular Weight:
  • 191.109
  • Density:
  • 1.484
  • Boiling Point:
  • 259.3 °C at 760 mmHg
  • Melting Point:
  • 193-197℃
  • Flash Point:
  • 110.6 °C
  • Storage Temperature:
  • Inert atmosphere,Room Temperature
  • Refractive index:
  • 1.475
  • More Properties>>
Question & Answer
Upstream Product Downtream information
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6-(Trifluoromethyl)nicotinic acid
6-(Trifluoromethyl)nicotinic acid
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6-(Trifluoromethyl)nicotinic acid
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6-(Trifluoromethyl)nicotinic acid
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  • Description:Name: 6-(Trifluoromethyl)nicotinic acid Synonyms: 6-(Trifluoromethyl)pyridine-3-carboxylic acid; 6-Trifluoromethyl Nicotinic acid CAS Registry number: 231291-22-8 Molecular Formula: C7H4F3NO2 Boiling Point: 259.3 °C at 760 mmHg Flash Point: 110.6 °C Density: 1...
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6-(trifluoromethyl)pyridin-3-carboxylic acid
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6-(Trifluoromethyl)nicotinic acid
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6-(Trifluoromethyl)nicotinic acid,factory supply
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3-Pyridinecarboxylicacid, 6-(trifluoromethyl)- 231291-22-8 C7H4F3NO2
3-Pyridinecarboxylicacid, 6-(trifluoromethyl)- 231291-22-8 C...
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  • Brand:H.X.K 
  • Description:Product Name: 3-Pyridinecarboxylicacid, 6-(trifluoromethyl)- 130×55 Product Number: B100330 CAS Number: 231291-22-8 Formula: C7H4F3NO2 Molecular Weight: 191.11 Appearance: - Bp(Mp): - ℃ density: - g/ml
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6-(Trifluoromethyl)nicotinic acid
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  • Description:【Name】 6-(trifluoromethyl)nicotinic acid 【CAS】 231291-22-8 【Synonyms】 2-TRIFLU
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6-(Trifluoromethyl)nicotinic acid
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6-(Trifluoromethyl)nicotinic acid
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6-(Trifluoromethyl)pyridine-3-carboxylic Acid
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