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Home> Products > Organic Intermediates > Pharmaceutical Intermediates > CAS DataBase Listed 3 > CAS 377727-87-2
377727-87-2 structure

CAS 377727-87-2 Unii-950o97nupo products price,suppliers

  • Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.


    Preladenant has been used in trials studying the treatment of Brain Diseases, Parkinson Disease, Movement Disorders, Antipsychotic Agents, and Parkinsonian Disorders, among others.|Preladenant is an orally bioavailable antagonist of the adenosine A2A receptor (A2AR; ADORA2A), with potential immunomodulating and antineoplastic activities. Upon administration, preladenant selectively binds to and inhibits A2AR expressed on T-lymphocytes. This blocks tumor-released adenosine from interacting with A2AR and prevents the adenosine/A2AR-mediated inhibition of T-lymphocytes. This results in the proliferation and activation of T-lymphocytes, and stimulates a T-cell-mediated immune response against tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits T-cell proliferation and activation. Adenosine is often overproduced by cancer cells and plays a key role in immunosuppression.

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  • Name: Unii-950o97nupo
  • Molecular Weight: 503.5563
  • Formula: C25H29N9O3
  • Synonyms: 2-(2-Furanyl)-7-[2-[4-[4-(2-Methoxyethoxy)phenyl]-1-piperazinyl]ethyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyriMidin-5-aMine; 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)-ethyl)-7H-pyrazolo[4,3-e][1,2,4; 2-Furan-2-yl-7-(2-{4-[4-(2-Methoxy-ethoxy)-phenyl]-piperazin-1-yl}-ethyl)-7,9a-dihydro-5H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyriMidin-5-ylaMine; 2-Furan-2-yl-7-(2-{4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl}ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine; 7H-Pyrazolo(4,3-E)(1,2,4)triazolo(1,5-C)pyrimidin-5-amine, 2-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl)-; 7H-Pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-amine,2-(2-furanyl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)-1-piperazinyl)ethyl);
Properties Safety and Handling MSDS Computational chemical data
Identification
  • Cas NO.:377727-87-2
  • CID:10117987
  • Name:
  • Unii-950o97nupo (Related Reference)
  • InChI:
  • InChI=1S/C25H29N9O3/c1-35-15-16-36-19-6-4-18(5-7-19)32-11-8-31(9-12-32)10-13-33-23-20(17-27-33)24-28-22(21-3-2-14-37-21)30-34(24)25(26)29-23/h2-7,14,17H,8-13,15-16H2,1H3,(H2,26,29)
Safety Data
Properties
There are 19 suppliers who can provide Unii-950o97nupo with CAS No. 377727-87-2
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Unii-950o97nupo CAS 377727-87-2
Unii-950o97nupo CAS 377727-87-2
  • FOB Price:100 USD/kilogram 
  • Min.Order:1 Kilogram 
  • Supply Ability:1000 Kilogram/Day 
  • Appearance:white powder 
  • Purity:99% 
  • Packaging:5kg/drum, 10kg/drum,25kg/drum 
  • Usage:Syntheses Material Intermediates, Others 
  • Brand:Crovell 
  • Description:At present our company has a large number of spot, if you have any requirements, please contact me:Spring Whatsapp: + 86 19930507977 Wickr: springliu Wechat: 199 3050 7977 Telegram: 199 3050 7977
  • Updatetime:May 30 2023 
2-Furan-2-yl-7-(2-{4-[4-(2-Methoxy-ethoxy)-phenyl]-piperazin-1-yl}-ethyl)-7,9a-dihydro-5H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyriMidin-5-ylaMine
2-Furan-2-yl-7-(2-{4-[4-(2-Methoxy-ethoxy)-phenyl]-piperazin...
  • Min.Order:1 Kilogram 
  • Supply Ability:100 Kilogram/Quarter 
  • Appearance:White to off-white powde 
  • Purity:0.98 
  • Packaging:500g 
  • Usage:pharmaceutical Intermedaites 
  • Brand:Dochemical 
  • Description:Name: Unii-950o97nupo Molecular Formula: C25H29N9O3 Formula Weight: 503.55626
  • Updatetime:Nov 29 2022 
Unii-950o97nupo
Unii-950o97nupo
  • Min.Order:10 Gram 
  • Packaging:plastic bag,flouride bottle,fiber drums,plastic drums 
  • Brand:Aopharm 
  • Description:Unii-950o97nupo CAS 377727-87-2MFC7H5BrO2 MW 201.02Offer will be given soon after your inquiry.
  • Updatetime:May 05 2019 
Preladenant,SCH-420814; SCH 420814; SCH420814/377727-87-2/99% in stock
Preladenant,SCH-420814; SCH 420814; SCH420814/377727-87-2/99...
  • FOB Price:100 USD/gram 
  • Min.Order:1 Gram 
  • Supply Ability:1000 Gram/Week 
  • Appearance:white or off-white powder 
  • Purity:99% 
  • Packaging:1g/bag 10/bag 100g/bag 1kg/bag 10kg/ba... 
  • Description:Superiority high purity 99% in stock manufacturer from china Details Shengda Pharmaceutical Co.,Limited was established in December 2009 for Hongkong. We are a leading high-tech enterprise expertised in researching, developing and manufacturing innovative and ...
  • Updatetime:Jul 06 2022 
Preladenant
Preladenant
  • Appearance:Solid 
  • Purity:99% 
  • Packaging:1g/bag, 5g/bag 
  • Description:Superiority wuhan sunrise technology development company limited(wuhan sunrise pharmaceutical tehcnology co., ltd) wuhan sunrise technology development company limited is a high-tech pharmaceutical enterprise dedicated to r&d of chemical drug. the main busines...
  • Updatetime:Apr 01 2019 
Preladenant
Preladenant
  • Appearance:White-Off White Powder 
  • Purity:98% 
  • Packaging:As per client requirement 
  • Description:Superiority we supply 1.in very competitive price; 2.quality guaranteed; 3.fast delivery; Details AvansCure was established to provide global sourcing and international marketing expertise services to pharmaceutical, biotech and medical devices companies in th...
  • Updatetime:Feb 25 2019 
Preladenant
Preladenant
  • Min.Order:0 Metric Ton 
  • Supply Ability:Metric Ton/Day 
  • Purity:98 
  • Description:Superiority name:preladenant synonyms:2-(2-furanyl)-7-[2-[4-[4-(2-methoxyethoxy)phenyl]-1-piperazinyl]ethyl]-7h-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine; sch 420814 cas no.:377727-87-2 Details Keywords:Preladenant,377727-87-2,2-(2-Furanyl)-7-[2-[...
  • Updatetime:Feb 24 2019 
Unii-950o97nupo/377727-87-2
Unii-950o97nupo/377727-87-2
  • Min.Order:0 Metric Ton 
  • Supply Ability:Metric Ton/Day 
  • Appearance:white powder 
  • Purity:98% 
  • Packaging:1g 
  • Description:Superiority in stock Details Molecular Formula:C25H29N9O3 Storage:RT Keywords:377727-87-2,SCH-420814,Preladenant
  • Updatetime:Feb 25 2019 
Preladenant
Preladenant
  • Purity:98.0% 
  • Packaging:10g, 100g,1kg, 5kg, 10kg, 7129kg 
  • Description:Superiority 1.we are specializing in providing customers with complete chemical raw materials. 2.superior quality, moderate price & quick delivery. 3. extensive international cooperation experience. 7034. outstanding communication skills. Details pharmaceutica...
  • Updatetime:Feb 25 2019 
SCH 420814
SCH 420814
  • Purity:98% 
  • Packaging:As per Customer‘ requirements 
  • Description:Superiority good price, high purity, mature production technology, in stock, accept custom synthesis per customer's requirements Details Senova means "Serve For Innovation", we are a professional company who's supplying APIs(mainly New Generics), Advanced Inte...
  • Updatetime:Feb 23 2019 
CAS 377727-87-2, Unii-950o97nupo, C25H29N9O3
CAS 377727-87-2, Unii-950o97nupo, C25H29N9O3
  • Min.Order:0 Metric Ton 
  • Supply Ability:Metric Ton/Day 
  • Purity:99% 
  • Description:Superiority cas 377727-87-2, unii-950o97nupo, c25h29n9o3 Details Keywords:CAS 377727-87-2, Unii-950o97nupo, C25H29N9O3,STOCK,good price
  • Updatetime:Feb 25 2019 
2-(furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
2-(furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-...
  • Purity:95 
  • Description:Superiority high quality,stable supply,all in stock Details Molecular Formula:C25H29N9O3 Keywords:2-(furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
  • Updatetime:Feb 25 2019 
Preladenant
Preladenant
  • Purity:98% 
  • Packaging:Asyourrequirement 
  • Description:Superiority wehaveamaturetechnologhyandhavestockinhand Details Transportation:ByExpress Keywords:SCH420814
  • Updatetime:Feb 25 2019 
SCH-420814
SCH-420814
  • Description:Superiority sch-420814 Details SCH-420814
  • Updatetime:Feb 25 2019 
Preladenant
Preladenant
  • Purity:98% 
  • Updatetime:Apr 01 2019 
Preladenant
Preladenant
  • Purity:98% 
  • Updatetime:Apr 01 2019 
Preladenant
Preladenant
  • Purity:98% 
  • Updatetime:Apr 01 2019 
Preladenant
Preladenant
  • Updatetime:Nov 25 2019 
377727-87-2
  • Updatetime:Mar 29 2019 
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