CAS 68774-77-6 8-CHLORO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE | Products & Prices & Suppliers

It was stirred for 4 hours at reflux mixture of the compound obtained in Step 1 (8 g) and triethyl orthoformate (32 mL). The reaction solution was cooled to room temperature, the precipitated solid was washed after filtration, with ethanol, To give the title compound followed by drying under reduced pressure (8.10g, 95percent).A mixture of l-(3-chloropyrazin-2-yl)hydrazine (0.90 g, 62 mmol), triethyl orthoformate (2.3 mL), 14 mmol), and dry xylene (15 mL) was refluxed with stirring for 2 h. The mixture was brought to RT, diethyl ether was added and the suspension was filtered. The solid collected was washed with diethyl ether to afford 8-chloro-[l, 2, 4]triazolo[4, 3- ajpyrazine (0.60 g, 62percent yield). MS m/z: 155.0 (M+l).Step 3: Compound 49A is added to trimethyl orthoformate, The temperature was raised to reflux for 10 hours, cooled to room temperature, and filtered.Obtaining Compound 49B Solid(2 g, yield 70percent).