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Home> Products > Pharmaceuticals and Biochemicals > Cardiovascular Agents > CAS DataBase Listed 7 > CAS 75330-75-5
75330-75-5 structure 3D

CAS 75330-75-5 products price,suppliers

  • Lovastatin is a hexahydro naphthalene ester isolated from Aspergillus terreus broth. It is an inactive lactone only yielding activity upon hydrolysis after oral administration. It has a strong competitive inhibition on the HMG-CoA reductase in the liver. HMG-CoA reductase is rate-limiting enzyme for de novo cholesterol synthesis in vivo. The inhibition of the enzyme can block the conversion of HMG-CoA to methacrylic acid, causing significant reduction in cholesterol synthesis, and leading to increased expression of the liver LDL receptor which promotes the plasma LDL-C clearance. The reduction of cholesterol synthesis can also cause reduced synthesis of liver ApoB100, thus causing that reduction of VLDL synthesis. Clinical observations show that it has a good effect of lowering of plasma total cholesterol and LDLC on hypercholesterolemia caused by various kinds of reasons such as heterozygous familial hypercholesterolemia, polygenic hypercholesterolemia, and diabetes or kidney disease syndrome.Statins are the secondary metabolites of filamentous fungi. It is capable of selectively inhibiting the activity of HMG coenzyme A (HMG-CoA) reductase and blocking cholesterol biosynthesis, which is due to the similarity of its acid structure with HMG-CoA. These drugs currently used in humans (statin drugs, statins) are mainly either natural or synthetic statins. Natural statins include lovastatin, mevastatin, Pravastatin and simvastatin. Lovastatin is produced by the fermentation of Aspergillus terreus); mevastatin is produced through the fermentation of penicillium citrinum and further conversion by streptomyces carbophilus; Simvastatin is made by semi-synthesis (chemically modified side chains) through lovastatin. Synthetic statins include fluvastatin, cerivastatin and atorvastatin.
  • Name: Benzenesulfonamide,N-[4-[(3S)-1-propyl-3-pyrrolidinyl]phenyl]-3-(trifluoromethoxy)-
  • Molecular Weight: 404.547
  • Formula: C15H16N4O3
  • Synonyms: (+)-Mevinolin; (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl (S)-2-Methylbutyrate; (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl (2S)-2-methylbutanoate; (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate; (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl-(2S)-2-methylbutanoat; (2S)-2-Methylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester;
Properties Safety and Handling MSDS Synthesis Route Precursor and Product Computational chemical data
Identification
Safety Data
  • [Risk Codes]
  • R36/37/38:Irritating to eyes, respiratory system and skin
  • [Safety Statements]
  • S22:Do not breathe dust
  • S24/25:Avoid contact with skin and eyes
  • Hazard Symbols:
  • HazardClass:9
Properties
  • Molecular Weight:
  • 404.547
  • Melting Point:
  • 175℃
  • Storage Temperature:
  • 2-8°C
  • Refractive index:
  • 320 ° (C=0.5, CH3CN)
  • Solubility:
  • 0.0004 mg/mL at 25 oC
  • Stability:
  • Stable under recommended storage conditions.
  • More Properties>>
Upstream Product Downtream information
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Lovastatin CAS No.: 75330-75-5
Lovastatin CAS No.: 75330-75-5
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Lovastatin CAS.75330-75-5
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  • Description:Quick Details Classification: Pharmaceutical Intermediates Cas NO.:75330-75-5 Name:Lovastatin Formula:C24H36O5 Boiling Point: 559
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lovastatin Cas 75330-75-5 from China
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Factory supply Lovastatin,cas:75330-75-5
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Hot selling high quality Lovastatin Cas 75330-75-5 with favorable price and good service
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  • Description:Name: Lovastatin Synonyms: MK-803;Belvas;(1S-(1alpha(R),3alpha,7beta,8beta(2S,4S),8abeta))-(1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthyl) 2-methylbutanoate;Rodatin;Paschol;Artein;Butanoic acid, 2-methyl-,...
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Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hex...
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  • Description:Lovastatin 【 Synonyms 】1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2-methylbutanoate 【 CAS No. 】75330-75-5
  • Updatetime:Nov 02 2020 
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factory supply Red yeast rice extract Lovastatin/Monacolin K
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  • Description:factory supply Red yeast rice extract Lovastatin/Monacolin K Brief Description Latin name: monascus purpureus Plant Origin: seed Active ingredient: (Monacolin K) Specification: 1%.1.5%,2%,2.5%.3%.4%.5% Assay Method: HPLC CAS No.:75330-75-5 Appearance: Red fine...
  • Updatetime:Mar 03 2016 
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