Guidechem | China Chemical Manufacturers,suppliers,B2B Marketplace
Products
  • Products
  • Encyclopedia
  • Buy offers
  • Suppliers
Home> Products > Organic Intermediates > Pharmaceutical Intermediates > CAS DataBase Listed 8 > CAS 857064-38-1
857064-38-1 structure

CAS 857064-38-1 WP1066 products price,suppliers

  • WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.


    WP1066 has been used in trials studying the treatment of Melanoma, Brain Cancer, Solid Tumors, and Central Nervous System Neoplasms.|STAT3 Inhibitor WP1066 is an orally bioavailable, small molecule inhibitor of signaling transducer and activator 3 (STAT3), with potential antineoplastic and immunomodulatory activities. Upon administration, STAT3 inhibitor WP1066 blocks the intranuclear translocation of p-STAT, thereby suppressing STAT3 signaling and decreasing the levels of downstream products including c-Myc. Additionally, WP1066 may upregulate costimulatory molecules including CD80 and CD86 on human microglia, and reverse glioma cancer stem cell (gCSC)-mediated innate and adaptive immune suppression allowing for the restoration of antitumor effector immune responses. The STAT3 pathway is overly active in many cancer types and is implicated in CSC-mediated growth, recurrence and resistance to conventional chemotherapies.

  • + show more
  • Name: WP1066
  • Molecular Weight: 356.21656
  • Formula: C17H14BrN3O
  • Synonyms: (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide; (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide WP 1066; Stat3 Inhibitor III, WP1066; WP1066; wp1066(STAT Inhibitor III); WP1066/WP-1066;
Properties Safety and Handling MSDS Computational chemical data
Identification
  • Cas NO.:857064-38-1
  • CID:11210478
  • Name:
  • WP1066 (Related Reference)
  • InChI:
  • InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
Safety Data
Properties
  • Molecular Weight:
  • 356.21656
  • Density:
  • 1.425
  • Boiling Point:
  • 569.9±50.0 °C at 760 mmHg
  • Flash Point:
  • 298.5±30.1 °C
  • Storage Temperature:
  • +2C to +8C
  • Refractive index:
  • 1.637
  • More Properties>>
There are 26 suppliers who can provide WP1066 with CAS No. 857064-38-1
Country:
Purity:
Unit:
Business Type:
WP1066  857064-38-1 supplier
WP1066 857064-38-1 supplier
  • Min.Order:1 Milligram 
  • Supply Ability:100 Metric Ton/Year 
  • Appearance:powder 
  • Purity:99% 
  • Packaging:as your required 
  • Description:Superiority nanjing sunsure chemical technology co., ltd., established in 2009, has expanded a compositive entity from initially only as a small manufacturer. the company dedicated to the development, production and marketing of chemicals. sunsure covers whole...
  • Updatetime:Feb 25 2019 
WP1066
WP1066
  • FOB Price:65 USD/10mg 
  • Min.Order:10 mg 
  • Supply Ability:10 Gram/Month 
  • Appearance:powder 
  • Purity:99% 
  • Packaging:10mg, 100mg, 1g, 5g, 10g, 1kg 
  • Description:Introduction: WP1066 is a novel analog of the JAK2 inhibitor AG490, and significantly more potent and active against human malignant glioma cells in vitro and in vivo. · CAS Number: 857064-38-1 Name: 2-Propenamide, 3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phe...
  • Updatetime:Mar 16 2015 
WP1066/857064-38-1/99% in stock
WP1066/857064-38-1/99% in stock
  • FOB Price:1 USD/gram 
  • Min.Order:1 Gram 
  • Supply Ability:1000 Gram/Month 
  • Appearance:white or off-white crystalline powder 
  • Purity:99% 
  • Packaging:depends on customer's requirement 
  • Description:Superiority 1.direct manufacturer Details 名称 (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide Molecular Formula:C17H14BrN3O Transportation:by courier or by air Storage:keep away from heat, sparks and flames Keywords:WP1066, 857064-38-1,(S,E)...
  • Updatetime:Jul 06 2022 
WP 1066
WP 1066
  • FOB Price:500 USD/gram 
  • Min.Order:1000 Gram 
  • Supply Ability:100 Kilogram/Day 
  • Appearance:appearance White powder 
  • Purity:99.5 
  • Packaging:1000 g/aluminum foil bag 
  • Description:Superiority chengdu and import and export trade co., ltd., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research ...
  • Updatetime:Feb 25 2019 
WP 1066
WP 1066
  • FOB Price:4,862.00-4,862.00 USD/gram 
  • Min.Order:0 Gram 
  • Appearance:powder 
  • Purity:99% 
  • Packaging:10mg, 100mg, 1g, 1kg 
  • Description:Superiority cas?number:?857064-38-1 name:?2-propenamide,?3-(6-bromo-2-pyridinyl)-2-cyano-n-[(1s)-1-phenylethyl]-,?(2e)- ? · superlist?… Details CAS?Number:?857064-38-1 Name:?2-Propenamide,?3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-,?(2E)- ? · Sup...
  • Updatetime:Feb 25 2019 
WP 1066
WP 1066
  • Min.Order:0 Metric Ton 
  • Supply Ability:Metric Ton/Day 
  • Appearance:white powder 
  • Purity:98% 
  • Packaging:Aluminum foil bag 
  • Description:Superiority high quality , competitive price , in stock. Details Molecular Formula:C17H14BrN3O Transportation:By Air, Storage:customer requirements Keywords:WP 1066 supplier,WP 1066 price,857064-38-1 in stock
  • Updatetime:Feb 25 2019 
WP1066
WP1066
  • Min.Order:1 Gram 
  • Supply Ability:100g Metric Ton/Day 
  • Purity:99% 
  • Description:Superiority in stock ,if you need hnmr\hplc,please contact us! excellent quality and reasonable price and absolutely worthy. Details WP1066 is a novel inhibitor of JAK2
  • Updatetime:Feb 25 2019 
Stat3 Inhibitor III, WP1066
Stat3 Inhibitor III, WP1066
  • Appearance:Solid 
  • Purity:99% 
  • Packaging:1g/bag, 5g/bag 
  • Description:Superiority wuhan sunrise technology development company limited(wuhan sunrise pharmaceutical tehcnology co., ltd) wuhan sunrise technology development company limited is a high-tech pharmaceutical enterprise dedicated to r&d of chemical drug. the main busines...
  • Updatetime:Apr 01 2019 
WP1066
WP1066
  • Purity:98% 
  • Packaging:1g,5g,10g,100g,1000g, 
  • Description:Superiority best quality & attractive price & professional service; kailiqi biopharma is leading by professional teams for years and is qualified as the superior supplier of merck, novartis, mitsui chemicals. kailiqi biopharma develop produce and distribute hi...
  • Updatetime:Feb 25 2019 
WP1066
WP1066
  • Purity:99% 
  • Description:Superiority we have two r&d center both in suzhou and nanjing. the r&d center owns labs with 2500m701 production base. and excellent staff, advanced equipments ,instruments, strict quality management system enhance our competitiveness.we are good at rare&hard ...
  • Updatetime:Feb 23 2019 
WP1066
WP1066
  • Purity:98% 
  • Packaging:Asyourrequirement 
  • Description:Superiority wehaveamaturetechnologhyandhavestockinhand Details Transportation:ByExpress Keywords:WP1066
  • Updatetime:Feb 25 2019 
(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acry...
  • Purity:95 
  • Packaging:250mg 
  • Description:Superiority comprehensive range product, high quality, quick shippment, coa with spectras Details Keywords:(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide,857064-38-1
  • Updatetime:Feb 23 2019 
WP1066
WP1066
  • Description:Synonyms:WP1066;(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide;WP1066/WP-1066;(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
  • Updatetime:Dec 20 2016 
WP 1066
WP 1066
  • Description:Superiority Details Molecular Formula:C17H14BrN3O
  • Updatetime:Feb 25 2019 
WP 1066
WP 1066
  • Description:Superiority Details Molecular Formula:C17H14BrN3O
  • Updatetime:Feb 25 2019 
WP 1066
WP 1066
  • Description:Superiority Details Molecular Formula:C17H14BrN3O
  • Updatetime:Feb 24 2019 
(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
<Pre12Next >
About Products and Service Guidechem will help you find WP1066 857064-38-1 suppliers from 1 different countries and regions around the world,26 products, both certified manufacturers and traders. You can choose and inquire according to your actual needs. Guidechem provides you with information matching service. If you have not found the right supplier, release the purchase inquiry, the system will automatically match the corresponding supplier for you, for you to quote, to meet your needs for product quality and price. Guidechem, with its platform of more than 100,000 suppliers, can meet all your needs for products. Please place your order now and start a happy purchasing experience.
Related Categories