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Current Position: Home > Dictionary EN > C > 108-91-8

Cyclohexylamine 108-91-8

108-91-8 Properties
Density 0.867
Boiling Point 133-134℃
Flash Point 27℃
Melting Point -17℃
Appearance Clear to yellow liquid
Vapour 8.07mmHg at 25°C
Refractive Index 1.458-1.46
Solubility miscible
Color/Form Colorless or yellow liquid.
HS Code 2921300090
Storage temp Flammables area
Spectral properties Index of refraction: 1.4565 @ 25 deg C/D
IR: SAD 845 (Sadtler Research Laboratories Prism Collection)
NMR: SAD 6937 (Sadtler Research Laboratories Spectral Collection)
MASS: NIST 27855 (NIST/EPA/MSDC Mass Spectral Database, 1990 version)
108-91-8 Safety Infomation
Safety Statements S1/2;S36/37/39;S45
Risk Statements R10;R21/22;R34
Hazard Codes C
HazardClass 8
Safety Hazard Codes:C
Risk Statements:10-21/22-34
21/22:Harmful by inhalation, in contact with skin and if swallowed
34:Causes burns
Safety Statements:36/37/39-45-1/2
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
1/2:Keep locked up and out of the reach of children
RIDADR:UN 2357 8/PG 2
WGK Germany:1
Hazardous Substances Data:108-91-8(Hazardous Substances Data)
Toxicity This is classified as very toxic -- probable oral lethal dose is 50-500 mg/kg or between 1 teaspoon and 1 ounce for a 70 kg (150 lb.) person. It is considered a nerve poison. This is a weak methemoglobin-forming substance.
PackingGroup II
Skin, Eye, and Respiratory Irritations Irritating to skin, eyes, and respiratory system.
Can cause dermatitis and convulsions.
Cleanup Methods Stop or control the leak, if this can be done without undue risk. Eliminate all ignition sources. Use water spray to cool and disperse vapors, protect personnel, and dilute spills to form nonflammable mixtures. Approach release from upwind. Absorb in noncombustible material for proper disposal.
Transport UN 2357
Fire Fighting Procedures Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Use water spray to keep fire-exposed containers cool. Solid streams of water may be ineffective and spread material.
Fire Potential FLAMMABLE LIQUID...
Dangerous fire hazard when exposed to heat, flame, or oxidizers.
DOT Emergency Guidelines /GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible materials. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing is recommended for fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Evacuation: ... Fire: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire: Some of these materials may react violently with water. Small fires: Dry chemical, CO2, water spray or alcohol-resistant foam. Large fires: Water spray, fog or alcohol-resistant foam. Move containers from fire area if you can do it without risk. Dike fire control water for later disposal; do not scatter the material. Do not get water inside containers. Fire involving tanks or car/trailer loads: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn.
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Spill or Leak: Fully encapsulating, vapor protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material and transfer to containers ... . Use clean non-sparking tools to collect absorbed material. Large spills: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor; but may not prevent ignition in closed spaces.
/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ First Aid: Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves.
Reactivities and Incompatibilities Oxidizers, organic compounds, acid anhydrides, acid chlorides, acids, lead [Note: Corrosive to copper, aluminum, zinc & galvanized steel].
Other Preventative Measures SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
The worker should immediately wash the skin when it becomes contaminated.
Work clothing that becomes wet should be immediately removed due to its flammability hazard.
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
Wear special protective clothing and positive pressure self-contained breathing apparatus.
Wear appropriate personal protective clothing to prevent skin contact.
Wear appropriate eye protection to prevent eye contact.
Eyewash fountains should be provided in areas where there is any possbility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection.
Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.]

The Cyclohexylamine, with the cas registry number 108-91-8, is a kind of colorless liquid with an odor of ammonia. Being sensitive to air and light, it is soluble in water and may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Besides, its product categories are including Pharmaceutical Intermediates.

The physical properties of this chemical are as follows: (1)ACD/LogP: 1.40; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.7; (4)ACD/LogD (pH 7.4): -1.44; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 3.24; (13)Index of Refraction: 1.459; (14)Molar Refractivity: 31.22 cm3; (15)Molar Volume: 114 cm3; (16)Polarizability: 12.37 ×10-24 cm3; (17)Surface Tension: 31.4 dyne/cm; (18)Density: 0.869 g/cm3; (19)Flash Point: 32.2 °C; (20)Enthalpy of Vaporization: 36.14 kJ/mol; (21)Boiling Point: 134.5 °C at 760 mmHg; (22)Vapour Pressure: 8.07 mmHg at 25°C.

Use of this chemical: Cyclohexylamine could react with N-tert-Butyl-3-oxobutyramid to produce N-tert-Butyl-3-(cyclohexylamino)crotonsaeure-amid, with the following condition: reagent: conc. HCl ; solvent: CH2Cl2; reaction temp.: 2 hours; yield: 87%.

As to its usage, it is widely applied in many ways. It could be used as the thiofide, the raw material for synthetic fibre, dye and vapour-phase inhibitor; It could also used in producing reactive dye, softening agent, solaziquone, and as the intermediate of phytocide Hexazinone, rubber accelerator, petroleum additive and rust inhibitor; Then it is usually used in organic synthesis, rubber synthesis, and also could be as the preservative and sour gas absorbent. When store it, keep it in a dry, cool and well-ventilated place, away from the oxidizing agent, acids.

When you are dealing with this kind of chemical, you should be much more careful and then take some measures to protect yourself. For one thing, it is corrosive which may destroy living tissue on contact. If in contact with skin and if swallowed, it will be harmful. For another thing, it is flammable and then causes burns. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. If in case of accident or if you feel unwell seek medical advice immediately (show the label where possible). When store it, keep locked up and out of the reach of children.

In addition, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: C1CCC(CC1)N
(2)InChI: InChI=1S/C6H13N/c7-6-4-2-1-3-5-6/h6H,1-5,7H2

Below are the toxicity information of this chemical:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 200mg/kg (200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65(1), Pg. 53S, 1969.
guinea pig LCLo inhalation 1200ppm/7H (1200ppm) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Industrial Medicine and Surgery. Vol. 19, Pg. 317, 1950.
mammal (species unspecified) LD50 intraperitoneal 200mg/kg (200mg/kg) BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES


AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 5, Pg. 311, 1952.
mouse LC50 inhalation 1070mg/m3 (1070mg/m3) BEHAVIORAL: EXCITEMENT

Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(11), Pg. 51, 1963.
mouse LD50 intraperitoneal 129mg/kg (129mg/kg) ? Pharmaceutical Chemistry Journal Vol. 22, Pg. 469, 1988.
mouse LD50 intravenous 200mg/kg (200mg/kg) ? International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.
mouse LD50 oral 224mg/kg (224mg/kg) ? "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 41, 1982.
mouse LD50 subcutaneous 1150mg/kg (1150mg/kg) ? Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. Vol. 4, Pg. 659, 1958.
mouse LD50 unreported 770mg/kg (770mg/kg) ? Toxicology and Applied Pharmacology. Vol. 14, Pg. 654, 1969.
rabbit LCLo inhalation 150ppm/7H (150ppm) ? Industrial Medicine and Surgery. Vol. 19, Pg. 317, 1950.
rabbit LD50 skin 320uL/kg (0.32mL/kg) ? American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rabbit LDLo parenteral 500mg/kg (500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Industrial and Engineering Chemistry. Vol. 29, Pg. 1247, 1937.
rat LC50 inhalation 7500mg/m3 (7500mg/m3) BEHAVIORAL: EXCITEMENT

Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 7(11), Pg. 51, 1963.


Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65(1), Pg. 53S, 1969.
rat LD50 oral 11mg/kg (11mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)


National Technical Information Service. Vol. OTS0534836,

Octanol/Water Partition Coefficient log Kow = 1.49
Disposal Methods SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
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