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Current Position: Home > Dictionary EN > H > 26833-87-4

26833-87-4

Chemical Name Homoharringtonine
CAS Registry Number 26833-87-4
PubChemID 285033
Molecular Weight 545.629
PSA 134.99000
LogP 2.60430
EINECS
Molecular Formula C29H39NO9
Aliases
 
26833-87-4 Properties
Density 1.33
Boiling Point 713.1 ºC at 760 mmHg
Flash Point 385.1 ºC
Melting Point 144-146 °C
Appearance Off-white Cryst
Vapour 2.41E-21mmHg at 25°C
Refractive Index 1.604
Solubility Soluble in DMSO or 100% ethanol.
Storage temp 2-8°C
 
26833-87-4 Safety Infomation
Safety Statements 36/37/39-45-27-26
Risk Statements R26/27/28
Hazard Codes T+; Xi
HazardClass 6.1(a)
Safety

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
Safety information of Homoharringtonine (CAS NO.26833-87-4):
Hazard Codes: T+,Xi
Risk Statements: 26/27/28-36/37/38
R26/27/28: Very Toxic by inhalation, in contact with skin and if swallowed
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 36/37/39-45-27-26
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S27: Take off immediately all contaminated clothing
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
RIDADR: UN 1544 6.1/PG 2
WGK Germany: 3
RTECS: FK0260000
HazardClass: 6.1(a)
PackingGroup: II

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD10 intravenous 640ug/kg (0.64mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

CARDIAC: CHANGE IN RATE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Cancer Institute Report. Vol. AUG1982,
mouse LD50 intraperitoneal 3170ug/kg (3.17mg/kg) ? Chinese Medical Journal Vol. 92, Pg. 175, 1979.
mouse LD50 intravenous 2400ug/kg (2.4mg/kg) ? Journal of Ethnopharmacology. Vol. 24, Pg. 1, 1988.
mouse LD50 oral 7456ug/kg (7.456mg/kg) ? National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse LD50 subcutaneous 3948ug/kg (3.948mg/kg) ? National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,

PackingGroup II
Transport UN 1544 6
Specification

? Homoharringtonine (CAS NO.26833-87-4), its Synonyms are 1-((1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H-cyclopenta(a)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-yl) 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate ; Ceflatonin ; Myelostat ; Omacetaxine mepesuccinate ; Omapro ; Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) (9CI) ; Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), (3(R))- (9CI) ; Cephalotaxine, 4-methyl-, 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester) ; Homoharringtonine (8CI) .

 
26833-87-4 Specturm
 
 
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