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Current Position: Home > Dictionary EN > A > 41294-56-8
 
41294-56-8 Properties
Density 1.01
Boiling Point 531.5oC at 760 mmHg
Flash Point 222.6 oC
Melting Point 136oC
Appearance white to off-white crystalline powder
Refractive Index 1.534
Solubility Practically insoluble in water, freely soluble in ethanol (96 per cent), soluble in fatty oils.
Stability Stable at normal temperatures and pressures.
HS Code 29361000
Storage temp −20°C
 
41294-56-8 Safety Infomation
Safety Statements 28-36/37-45-36-26
Risk Statements R26/27/28
Hazard Codes T+; Xi
HazardClass 6.1(a)
Hazard Note H300 + H310 + H330
Safety

Hazard Codes Alfacalcidolum (CAS NO.41294-56-8):?VeryT+,IrritantXi
Risk Statements: 26/27/28-36/37/38?
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 28-36/37-45-26?
S28: After contact with skin, wash immediately with plenty of soap-suds.?
S36/37: Wear suitable protective clothing and gloves.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: VS2851000
F: 8-10
HazardClass: 6.1(a)
PackingGroup: I

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 200ug/kg (0.2mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 103, 1978.
dog LD50 oral 500ug/kg (0.5mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 9, Pg. 103, 1978.
mouse LD50 intravenous 56ug/kg (0.056mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

MUSCULOSKELETAL: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Toxicology and Applied Pharmacology. Vol. 36, Pg. 323, 1976.
mouse LD50 oral 440ug/kg (0.44mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BLOOD: CHANGES IN SPLEEN

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 560, 1977.
mouse LD50 subcutaneous 55ug/kg (0.055mg/kg) ? PCT Vol. #86-05395,
rat LD50 intravenous 101ug/kg (0.101mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE

BLOOD: CHANGES IN SPLEEN
Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 653, 1978.
rat LD50 oral 340ug/kg (0.34mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

ENDOCRINE: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 560, 1977.
rat LD50 subcutaneous 40ug/kg (0.04mg/kg) ? PCT Vol. #86-05395,

PackingGroup I
Transport 281
Specification
White Solid
usageEng:A synthetic analog of Calcitiol (the hormonal form of vitamin D3), which shows identical potency with respect to stimulation of intestinal calcium absorption and bone mineral mobilization. Vitamin D source
Safety Statements:28-36/37-45-36-26
28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36/37:Wear suitable protective clothing and gloves
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36:Wear suitable protective clothing
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
 
41294-56-8 NMR Specturm
 
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