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Current Position: Home > Dictionary EN > I > 50847-11-5

Ibudilast 50847-11-5

Chemical Name Ibudilast
CAS Registry Number 50847-11-5
PubChemID 3671
Molecular Weight 230.30552
PSA 34.37000
LogP 3.29640
EINECS
Molecular Formula C14H18N2O
 
50847-11-5 Properties
Density 1.09
Boiling Point 175°C/7.5mmHg(lit.)
Melting Point 53-54℃
Appearance white solid
Refractive Index 1.57
Solubility DMSO: 28 mg/mL, soluble
Color/Form white
HS Code 2933990090
Storage temp 2-8°C
 
50847-11-5 Safety Infomation
Safety Statements S26;S36
Risk Statements R22;R36/37/38
Hazard Codes Xn
Safety

Safety Information about?Ibudilast (CAS NO.50847-11-5):
Hazard Codes:?HarmfulXn
Risk Statements: 22-36/37/38
R22: Harmful if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: UR0711200

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 460mg/kg (460mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse LD50 intravenous 146mg/kg (146mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse LD50 oral 1860mg/kg (1860mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse LD50 subcutaneous 3100mg/kg (3100mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat LD50 intraperitoneal 419mg/kg (419mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat LD50 intravenous 42500ug/kg (42.5mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
KIDNEY, URETER, AND BLADDER: HEMATURIA
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat LD50 oral 1340mg/kg (1340mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat LD50 subcutaneous 1300mg/kg (1300mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.

Specification
White Solid
usageEng:A leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
 
 
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