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Current Position: Home > Dictionary EN > 4 > 5382-16-1


Chemical Name 4-Hydroxypiperidine
CAS Registry Number 5382-16-1
PubChemID 79341
Molecular Weight 101.149
PSA 32.26000
LogP 0.05950
EINECS 226-373-1
Molecular Formula C5H11NO
5382-16-1 Properties
Density 108
Boiling Point 108-114℃ (10 mmHg)
Flash Point 107℃
Melting Point 86-90℃
Appearance yellow to yellow-orange wet solid
Solubility soluble in water
Stability No data.
HS Code 29333999
Storage temp Store in a cool, dry place. Store in a tightly closed container.
5382-16-1 Safety Infomation
Safety Statements S26;S37/39
Risk Statements R36/37/38
Hazard Codes Xi
HazardClass 8
PackingGroup III
Sensitive Hygroscopic
Transport UN 2811

The IUPAC name of?4-Hydroxypiperidine is?piperidin-4-ol. With the?CAS registry number 5382-16-1, it is also named?as?4-Piperidinol;?NSC 62083;?AI3-39158.?The product's categories are?alcohols and derivatives, amines and anilines, piperidines, piperidones, piperazines, pyrans, piperidines & piperazines, piperidine, heterocyclic compounds and pyrans and?piperidines & piperazines. It is?yellow to yellow-orange wet solid?which is soluble in water.

The other characteristics of this product can be summarized as:?(1)ACD/LogP: -0.52; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.61; (4)ACD/LogD (pH 7.4): -3.33; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.474; (13)Molar Refractivity: 27.99 cm3; (14)Molar Volume: 99.4 cm3; (15)Polarizability: 11.09×10-24 cm3; (16)Surface Tension: 33.7 dyne/cm; (17)Enthalpy of Vaporization: 53.31 kJ/mol; (18)Vapour Pressure: 0.0214 mmHg at 25°C; (19)Exact Mass: 101.084064; (20)MonoIsotopic Mass: 101.084064; (21)Topological Polar Surface Area: 32.3; (22)Heavy Atom Count: 7.

Uses of?4-Hydroxypiperidine: 1. It can react with?2-bromomethyl-[1,3]dioxolane?to get?1-(1,3-dioxolan-2-ylmethyl)-4-piperidinol.?This reaction needs reagent?K2CO3 and solvent?acetonitrile?by heating. The reaction time is?15 hours. The yield is 83.5%.

2. It also reacts with?4-chloromethyl-[1,3]dioxolane?to obtain?1-[1,3]dioxolan-4-ylmethyl-piperidin-4-ol.?This reaction needs reagent K2CO3 and solvent acetonitrile by heating. The reaction time is 16?hours. The yield is 56.4%.

When you are using this chemical, please be cautious about it as the following:
It can causes burns.?And?it is irritating to eyes, respiratory system and skin.?In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?Take off immediately all contaminated clothing.?If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.?In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
2.?InChI: InChI=1/C5H11NO/c7-5-1-3-6-4-2-5/h5-7H,1-4H2.

5382-16-1   Synthesis Route
Total: 2 Synthesis Route
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