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Current Position: Home > Dictionary EN > N > 59-67-6

59-67-6

Chemical Name Nicotinic acid
CAS Registry Number 59-67-6
PubChemID 938
Molecular Weight 123.111
PSA 50.19000
LogP 0.77980
EINECS 200-441-0
Molecular Formula C6H5NO2
Aliases
 
59-67-6 Properties
Density 1.473
Boiling Point 457° F (NTP, 1992)
Flash Point 193°C c.c.
Melting Point 234-238℃
Appearance White crystalline powder
Vapour 9.36X10-5 mm Hg at 25 deg C (est)
Refractive Index 1.4936
Solubility Slightly soluble
Color/Form Needles from alc or water
Colorless needles
Other physical and chemical properties PHYSICAL DESCRIPTION: Odorless white crystalline powder with a feebly acid taste. pH (saturated aqueous solution) 2.7. pH (1.3% solution) 3-3.5. (NTP, 1992)
Stability Stable. Incompatible with strong oxidizing agents. May be light sensitive.
HS Code 29362990
Storage temp 0-6°C
Spectral properties SADTLER REFERENCE NUMBER: 434 (IR, PRISM); 120 (IR, GRATING)
Max absorption: 263 nm
IR: 5076 (Coblentz Society Spectral Collection)
UV: 161 (Sadtler Research Laboratories Prism Collection)
1H NMR: 14671 (Sadtler Research Laboratories Spectral Collection)
MASS: 40521 (NIST/EPA/MSDC Mass Spectral database, 1990 version); 203 (National Bureau of Standards)
Intense mass spectral peaks: 78 m/z, 106 m/z, 137 m/z
 
59-67-6 Safety Infomation
Safety Statements S24/25
Risk Statements R36/37/38
Hazard Codes Xi
Hazard Note H319
Safety

Poison by intraperitoneal route. Moderately toxic by ingestion, intravenous, and subcutaneous routes. Human systemic effects: change in clotting factors, changes in platelet count. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:?Xi
Risk Statements: 36/37/38?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.?
S24/25: Avoid contact with skin and eyes.
WGK Germany of Niacin (CAS NO.59-67-6): 1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 3500mg/kg (3500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Proceedings of the Society for Experimental Biology and Medicine. Vol. 38, Pg. 241, 1938.
man TDLo intravenous 357ug/kg (0.357mg/kg) CARDIAC: CARDIAC OUTPUT
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Annals of Internal Medicine. Vol. 29, Pg. 558, 1948.
man TDLo oral 2571mg/kg/90D (2571mg/kg) BLOOD: CHANGE IN CLOTTING FACTORS
BLOOD: CHANGES IN PLATELET COUNT
Archives of Internal Medicine. Vol. 152, Pg. 861, 1992.
man TDLo oral 9713mg/kg/58W (9713mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING
SKIN AND APPENDAGES (SKIN): SWEATING: OTHER
Southern Medical Journal. Vol. 84, Pg. 496, 1991.
man TDLo oral 31200mg/kg/78 (31200mg/kg) SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
JAMA, Journal of the American Medical Association. Vol. 279, Pg. 1702, 1998.
mouse LD50 intraperitoneal 358mg/kg (358mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977.
mouse LD50 intravenous 5gm/kg (5000mg/kg) ? Therapie. Vol. 26, Pg. 831, 1971.
mouse LD50 oral 3720mg/kg (3720mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 149, 1973.
mouse LD50 subcutaneous 3500mg/kg (3500mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977.
mouse LD50 unreported 4gm/kg (4000mg/kg) ? British UK Patent Application. Vol. #2041937,
rabbit LD50 oral 4550mg/kg (4550mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977.
rat LD50 intraperitoneal 730mg/kg (730mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 14, Pg. 741, 1977.
rat LD50 oral 7gm/kg (7000mg/kg) ? Drugs in Japan Vol. 6, Pg. 544, 1982.
rat LD50 subcutaneous 5gm/kg (5000mg/kg) ? Drugs in Japan Vol. 6, Pg. 544, 1982.
rat LD50 unreported 4gm/kg (4000mg/kg) ? United States Patent Document. Vol. #4412998,
rat LDLo intravenous 3500mg/kg (3500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Proceedings of the Society for Experimental Biology and Medicine. Vol. 38, Pg. 241, 1938.

Skin, Eye, and Respiratory Irritations In the workplace, single or repeated contact can lead to a flush effect on the skin, including the face. The reddening is the result of increased peripheral blood circulation from dilation of capillaires at the skin surface. The flush effect is accompanied by sensations of itching, tingling, and warmness of the skin. It vanishes after the exposure has ended and is thus reversible.
Transport 25kgs
Formulations/Preparations GRADES: NATIONAL FORMULARY; FOOD CHEMICALS CODEX; BLENDED WITH SOY FLOUR (ANIMAL FEEDS)
Oral: Capsules, extended-release: 125 mg; 250 mg; 400 mg; 500 mg; Tablets: 50 mg 100 mg; 250 mg; 500 mg; (available by nonproprietary name). Tablets, extended-release: 250 mg Slo-Niacin, (Upsher-Smith); 500 mg Slo-Niacin, (Upsher-Smith); 750 mg Slo-Niacin, (Upsher-Smith).
Oral: Tablets, extended-release: 500 mg with Lovastatin 20 mg Advicor ( with povidone), (Kos); 750 mg with Lovastatin 20 mg Advicor ( with povidone), (Kos); 1 g with Lovastatin 20 mg Advicor ( with povidone), (Kos); 1 g with Lovastatin 40 mg Advicor ( with povidone), (Kos). /Niacin combinations/
Oral: Tablets: 500 mg Niacor (scored), (Upsher-Smith). Tablets, extended-release: 500 mg Niaspan, (Kos); 750 mg Niaspan, (Kos); 1000 mg Niaspan, (Kos).
Exposure Standards and Regulations Substance added directly to human food affirmed as generally recognized as safe (GRAS).
Niacin used as a nutrient and/or dietary supplement in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
Reactivities and Incompatibilities Dust explosion. Avoid contact with strong acids, alkaline solutions and oxidizing agents.
Protective Equipment and Clothing In the workplace, single or repeated contact can lead to a flush effect on the skin, including the face. The reddening is the result of increased peripheral blood circulation from dilation of capillaires at the skin surface. The flush effect is accompanied by sensations of itching, tingling, and warmness of the skin. It vanishes after the exposure has ended and is thus reversible.
Specification

?Niacin (CAS NO.59-67-6), its Synonyms are Nicotinic acid ; 3-Pyridinecarboxylic acid ; 3-Carboxypyridine ; Acide nicotinique ; Acido nicotinico ; Acidum nicotinicum ; Akotin ; Apelagrin ; Kyselina nikotinova ; Enduracin ; Daskil ; Davitamon PP ; Diacin ; Direktan ; Niaspan Titration Starter Pack ; Nicacid ; Nicagin ; Nicamin ; Nicangin ; Pyridine-3-carboxylic acid ; Pyridine-beta-carboxylic acid ; Pyridine-carboxylique-3 ; Pyridinecarboxylic acid, 3- . It is odorless white crystalline powder with a feebly acid taste.

Octanol/Water Partition Coefficient log Kow = 0.36
Report

Reported in EPA TSCA Inventory.

Disposal Methods SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
 
 
 
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