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Current Position: Home > Dictionary EN > C > 62571-86-2
 
62571-86-2 Properties
Density 1.2447 (rough estimate)
Boiling Point 427 °C at 760 mmHg
Flash Point 212.1 °C
Melting Point 104-108 °C(lit.)
Appearance White to off-white crystalline power
Refractive Index -127.5 ° (C=1.7, EtOH)
Alpha -129.5 o (C=1, ETOH)
Solubility soluble in water
Color/Form white to off-white
Stability Stable. Incompatible with strong oxidizing agents.
HS Code 2933990090
Storage temp Store in a cool, dry place. Store in a tightly closed container.
Spectral properties Specific optical rotation -131.0 deg @ 22 deg C/D (approx 1.7% in ethanol)
 
62571-86-2 Safety Infomation
Safety Statements 36/37-37/39-26-36-22
Risk Statements 43-63-36/37/38-40
Hazard Codes Xn,Xi
Safety

Hazard Codes:?HarmfulXn,IrritantXi
Risk Statements: 43-63-36/37/38-40
R43:May cause sensitization by skin contact.?
R63:Possible risk of harm to the unborn child.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R40:Limited evidence of a carcinogenic effect.
Safety Statements: 36/37-37/39-26-36-22
S36/37:Wear suitable protective clothing and gloves.?
S37/39:Wear suitable gloves and eye/face protection.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.?
S22:Do not breathe dust.
WGK Germany: 2
RTECS: UY0550000
Moderately toxic by intravenous route. Mildly toxic by ingestion. Human systemic effects: blood pressure lowering, changes in kidney function, decreased urine volume or anuria, dermatitis, dyspnea, hemolysis with or without anemia, metabolic changes, somnolence, ureter or bladder tubules failure. An experimental teratogen. Experimental reproductive effects. Used to treat refractory systemic hypertension and as an experimental drug in heart failure. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also MERCAPTANS.

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 600mg/kg (600mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING "Captopril and Hypertension, Collection of Papers presented at a Symposium, Princeton, N.J., 1979?," Case, David B., et al. eds., New York, Plenum Publishing, 1980Vol. -, Pg. 137, 1980.
man LDLo oral 2500ug/kg/3D- (2.5mg/kg) KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Postgraduate Medical Journal. Vol. 60, Pg. 561, 1984.
man LDLo oral 2680ug/kg/5D- (2.68mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Southern Medical Journal. Vol. 86, Pg. 1269, 1993.
man LDLo oral 16mg/kg (16mg/kg) ? Journal of Toxicology, Clinical Toxicology. Vol. 28, Pg. 379, 1990.
man TDLo oral 2679ug/kg/5D- (2.679mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Israel Journal of Medical Sciences. Vol. 21, Pg. 892, 1985.
man TDLo oral 4mg/kg/8D-I (4mg/kg) BEHAVIORAL: TOXIC PSYCHOSIS American Journal of Psychiatry. Vol. 142, Pg. 270, 1985.
man TDLo oral 7143ug/kg/2D- (7.143mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" British Medical Journal. Vol. 294, Pg. 91, 1987.
man TDLo oral 12500ug/kg/25 (12.5mg/kg) BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA Canadian Medical Association Journal. Vol. 129, Pg. 525, 1983.
man TDLo oral 87mg/kg/18W-I (87mg/kg) KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI

KIDNEY, URETER, AND BLADDER: PROTEINURIS

KIDNEY, URETER, AND BLADDER: HEMATURIA
Annals of Internal Medicine. Vol. 112, Pg. 550, 1990.
man TDLo oral 239mg/kg/6W-I (239mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BLOOD: NORMOCYTIC ANEMIA
American Journal of Medicine. Vol. 71, Pg. 493, 1981.
monkey LD oral > 1500mg/kg (1500mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING "Captopril and Hypertension, Collection of Papers presented at a Symposium, Princeton, N.J., 1979?," Case, David B., et al. eds., New York, Plenum Publishing, 1980Vol. -, Pg. 137, 1980.
mouse LD50 intravenous 663mg/kg (663mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 297, 1983.
mouse LD50 oral 2500mg/kg (2500mg/kg) ? Pharmaceutical Chemistry Journal Vol. 22, Pg. 212, 1988.
mouse LD50 subcutaneous > 2400mg/kg (2400mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2439, 1982.
rat LD50 intravenous 554mg/kg (554mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 297, 1983.
rat LD50 oral 4245mg/kg (4245mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 297, 1983.
rat LD50 subcutaneous > 600mg/kg (600mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2439, 1982.
women LDLo oral 1500ug/kg/7W (1.5mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Annals of Internal Medicine. Vol. 94, Pg. 58, 1981.
women TDLo oral 10mg/kg (10mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Annals of Emergency Medicine. Vol. 20, Pg. 1125, 1991.
women TDLo oral 10mg/kg/10D-I (10mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" British Medical Journal. Vol. 294, Pg. 91, 1987.
women TDLo oral 14mg/kg/2W-I (14mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Annals of Internal Medicine. Vol. 104, Pg. 126, 1986.

Formulations/Preparations Oral tablets: 25, 50, and 100 mg Capoten (scored).
Oral tablets 25 mg with Hydrochlorothiazide 15 mg, Capozide 25/15 (scored), Squibb; 25 mg with hydrochlorothiazide 25 mg, Capozide 25/25 (scored), Squibb; 50 mg with Hydrochlorothiazide 15 mg, Capozide 50/15 (scored), Squibb; 50 mg with Hydroxhlorothiazide 25 mg, Capozide 50/25 (scored), Squibb. /Captopril combinations/
Oral tablets 12.5 mg, 25 mg, 50 mg, 100 mg Capoten (scored), Squibb.
Each tablet for oral administration contains 12.5 mg, 25 mg, 50 mg or 100 mg of Captopril and the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, crospovidone, microcrystalline cellulose and stearic acid.
12.5-150 mg/d
Exposure Standards and Regulations Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).
Specification

? Captopril ,?its cas register number is 62571-86-2. It also can be called?(2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline ;
?(S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline ; 1-((2S)-3-Mercapto-2-methylpropionyl)-L-proline?; 1-(D-3-Mercapto-2-methyl-1-oxopropyl)-L-proline (S,S) ; 3-Mercapto-2-methylpropionyl-proline ; Alopresin ; Asisten ;?Captoprilum ; Cesplon ; D-3-Mercapto-2-methylpropanoyl-L-proline ; D-3-Mercapto-2-methylpropionylproline ; Garranil ;?Lopirin ; Tensoprel ; UNII-9G64RSX1XD . Captopril (CAS NO.62571-86-2) is?white crystalline powder.

Octanol/Water Partition Coefficient log Kow= 0.34 [Ranadive SA et al; Pharm Res 9: 1480-6 (1992)] PubMed Abstract
Disposal Methods SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
 
 
 
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