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Current Position: Home > Dictionary EN > S > 7647-14-5
 
7647-14-5 Properties
Density 1.199 g/mL at 20 °C
Boiling Point 100 °C750 mm Hg
Flash Point 1413°C
Melting Point 801 °C(lit.)
Appearance colourless crystals or white powder
Vapour 1 mm Hg ( 865 °C)
Refractive Index n20/D 1.378
Solubility 360 g/L (20 °C)
Color/Form White
Stability Stable. Incompatible with strong oxidizing agents.
HS Code 3822 00 00
Storage temp Store in a cool, dry, well-ventilated area away from incompatible substances.
Spectral properties Index of refraction: 1.5442
 
7647-14-5 Safety Infomation
Safety Statements 24/25-26-36
Risk Statements 36-36/37/38-22
Hazard Codes Xi
Safety Poison by intraperitoneal and intracervical routes. Moderately toxic by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: blood pressure increase. Human reproductive effects by intraplacental route: terminates pregnancy. Experimental reproductive effects. Human mutation data reported. A skin and eye irritant. When bulk sodium chloride is heated to high temperature, a vapor is emitted that is irritating, particularly to the eyes. Ingestion of large amounts of sodium chloride can cause irritation of the stomach. Improper use of salt tablets may produce this effect. Potentially explosive reaction with dichloromaleic anhydride + urea. Electrolysis of mixtures with nitrogen compounds may form the explosive nitrogen trichloride. Reaction with burning lithium forms the dangerously reactive sodium. The molten salt at 1100° reacts explosively with water. Violent reaction with BrF3. When heated to decomposition it emits toxic fumes of Cl- and Na2O.
Hazard Codes:?IrritantXi
The Risk Statements information of: Sodium chloride:
22:? Harmful if swallowed
36:? Irritating to the eyes
36/37/38:? Irritating to eyes, respiratory system and skin
The Safety Statements information of? Sodium chloride:
26:? In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:? Wear suitable protective clothing
24/25:? Avoid contact with skin and eyes
WGK Germany:? 1
F:? 3-10
Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 21, Pg. 119, 1886.
guinea pig LDLo intraarterial 300mg/kg (300mg/kg) ? Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig LDLo intravenous 300mg/kg (300mg/kg) ? Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig LDLo parenteral 300mg/kg (300mg/kg) ? Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig LDLo subcutaneous 2160mg/kg (2160mg/kg) ? "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
human TDLo oral 12357mg/kg/23 (12357mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION American Journal of Digestive Diseases. Vol. 21, Pg. 180, 1954.
man LDLo oral 1gm/kg (1000mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Mayo Clinic Proceedings. Vol. 65, Pg. 1587, 1990.
mouse LD50 intracervical 131mg/kg (131mg/kg) ? Tohoku Yakka Daigaku Kenkyu Nempo. Annual Report of the Tohoku College of Pharmacy. Vol. 27, Pg. 131, 1980.
mouse LD50 intraperitoneal 2602mg/kg (2602mg/kg) ? Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 256, Pg. 1043, 1963.
mouse LD50 intravenous 645mg/kg (645mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 445, 1957.
mouse LD50 oral 4gm/kg (4000mg/kg) ? Farmaco, Edizione Pratica. Vol. 27, Pg. 19, 1972.
mouse LD50 subcutaneous 3gm/kg (3000mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 445, 1957.
rabbit LD50 skin > 10gm/kg (10000mg/kg) ? BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 20-3/1971,
rabbit LDLo intravenous 1100mg/kg (1100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

CARDIAC: OTHER CHANGES
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 21, Pg. 119, 1886.
rabbit LDLo oral 8gm/kg (8000mg/kg) ? "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rat LC50 inhalation > 42gm/m3/1H (42000mg/m3) ? BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 20-3/1971,
rat LD50 oral 3gm/kg (3000mg/kg) ? Toxicology and Applied Pharmacology. Vol. 20, Pg. 57, 1971.
rat LDLo subcutaneous 3500mg/kg (3500mg/kg) BEHAVIORAL: IRRITABILITY Endocrinology Vol. 24, Pg. 523, 1939.

Sensitive Hygroscopic
Skin, Eye, and Respiratory Irritations Sodium chloride at concentrations much above that in tears causes a stinging sensation on contact with the eye.
Cleanup Methods Solids: Collect and remove with a broom in a large bucket. Dilute with water. Drain into the sewer with sufficient water. For solution: Wipe with mop or use water aspiration. Drain into the sewer with sufficient water.
Formulations/Preparations Intra-amniotic: Injection 20%
Highest purity medicinal, crystals; highest purity, dried; highest purity, fine powder; highest purity, fused; reagent; reagent, fused; sea evaporated; ground; microsized; powdered; table salt; rock salt; chemically pure; United States Pharmacopeia; "Food Chemicals Codex"; single pure crystals.
Some rock salt deposits contain pure, crystallized salt. This salt is extremely clear and free from defects. It is about 99.8% pure sodium chloride.
Iodized salt
Trade Name: Purex
Parenteral Injection: 0.9% (with benzyl alcohol or parabens)
Parenteral: Injection, for preparation of IV admixtures: 2.5 mEq of Na+/mL and Cl-/mL; 2.5 mEq of Na+/mL and Cl-/mL pharmacy bulk package Sodium Chloride Additive Solution, (American Pharmaceutical Partners), Sodium Chloride Additive Solution, (Hospira); 4 mEq of Na+/mL and Cl-/mL; 4 mEq of Na+/mL and Cl-/mL pharmacy bulk package Sodium Chloride Injection Concentrate MaxiVial, (American Pharmaceutical Partners).
Parenteral: Injection: 0.45%: 0.45% Sodium Chloride Injection, (Baxter); 0.45% Sodium Chloride Injection, (Braun); 0.45% Sodium Chloride Injection, (Hospira); 0.9%: 0.9% Sodium Chloride Injection, (Baxter); 0.9% Sodium Chloride Injection, (Braun); 0.9% Sodium Chloride Injection, (Hospira); 3% 3% Sodium Chloride Injection Hypertonic, (Baxter); 3% Sodium Chloride Injection Hypertonic, (Braun) 5%: 5% Sodium Chloride Injection Hypertonic, (Baxter), 5% Sodium Chloride Injection Hypertonic, (Braun), 5% Sodium Chloride Injection Hypertonic, (Hospira).
Oral: Inhalation Aerosol, sterile, for dilution of oral inhalation solutions: 0.9% Bronco Saline, (Blairex) Solution, for nebulization: 0.45% Arm-a-Vial Sodium Chloride Solution, (AstraZeneca); 0.9% Arm-a-Vial Sodium Chloride Solution, (AstraZeneca), Dey-Pak Sodium Chloride Solution, (Dey), Dey-Vial Sodium Chloride Solution, (Dey) Sodium Chloride Inhalation Solution, (Nephron), Sodium Chloride Inhalation Solution, (Roxane), Sodium Chloride Inhalation Solution, (Wyeth); 3% Dey-Pak Sodium Chloride Solution, (Dey); 10% Dey-Pak Sodium Chloride Solution, (Dey).
Local Solution, sterile, for irrigation: 0.45%: 0.45% Sodium Chloride Irrigation, (Baxter), 0.45% Sodium Chloride Irrigation, (Hospira); 0.9%: 0.9% Sodium Chloride Irrigation, (Baxter), 0.9% Sodium Chloride Irrigation, (Braun), 0.9% Sodium Chloride Irrigation, (Hospira) Tablets, for solution: 1 g (for preparation of 0.9% sodium chloride solution) Sodium Chloride Tablets, (Lilly).
Exposure Standards and Regulations The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed over-the-counter drug products, incl sodium chloride, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.
Reactivities and Incompatibilities Sodium chloride is rapidly attacked by bromine trifluoride.
Violent reaction with lithium.
Sodium chloride extinguishant should no be used on lithium fires since the reaction releases sodium and results in a more violent fire.
Electrolysis of sodium chloride in presence of nitrogenous compounds to produce chlorine may lead to formation of explosive nitrogen trichloride.
To prepare dichloromaleimide, sodium chloride, urea, and dichloromaleic anhydride are melted together with stirring. At 118 deg C the vigorous exothermic reaction sets in, and rapid ice cooling must then be applied to prevent explosion.
The mechanism of explosion of molten salt /eg, sodium chloride at 1100 deg C in accidental contact with water was studied.
The causes of furnace blasts occurring in soda-regeneration plants when water is split into molten sodium chloride are discussed, together with method of prevention.
Other Preventative Measures SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
Protective Equipment and Clothing Sodium chloride at concentrations much above that in tears causes a stinging sensation on contact with the eye.
Specification Sodium chloride (CAS NO.7647-14-5), also known as common salt, table salt, or halite,it also has synonyms such as Salt;Sea Salt;Tanker Fine Salt;Sodium Stock Solution.It is an ionic compound.
Report Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Disposal Methods

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
Put into large vessel containing water. Discharge into the sewer with sufficient water.

 
 
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