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Current Position: Home > Dictionary EN > C > 77-92-9
 
77-92-9 Properties
Density 1.542
Boiling Point 309.6 °C at 760 mmHg
Flash Point 100℃
Melting Point 153-154.5℃
Appearance White crystalline powder
Vapour 1.66e-08 mmHg
Refractive Index 1.493~1.509
Solubility 1 M at 20 °C in water, clear, colorless
Color/Form Powder
Stability Stable. Incompatible with bases, strong oxidizing agents, reducing agents, metal nitrates.
HS Code 2918140000
Storage temp Store at RT.
Spectral properties SADTLER REFERENCE NUMBER: 765 (IR, PRISM)
IR: 5104 (Coblentz Society Spectral Collection)
1H NMR: 7552 (Sadtler Research Laboratories Spectral Collection)
MASS: 8394 (NIST/EPA/MSDC Mass Spectral Database 1990 version)
 
77-92-9 Safety Infomation
Safety Statements S26;S37/39
Risk Statements R36/37/38
Hazard Codes Xi
Safety

Safety Information about?Citric Acid Anhydrous (CAS NO: 77-92-9):
Hazard Codes: Xi, C
Risk Statements: 41-36/37/38-34
41:?Risk of serious damage to eyes?
36/37/38:?Irritating to eyes, respiratory system and skin?
34:?Causes burns
Safety Statements: 26-24/25-36/37/39-45
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
24/25: Avoid contact with skin and eyes?
36/37/39: Wear suitable protective clothing, gloves and eye/face protection?
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR:?UN 1789 8/PG 3
WGK Germany : 1
F: 9: Keep under nitrogen.

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 903mg/kg (903mg/kg) ? Toxicology. Vol. 62, Pg. 203, 1990.
mouse LD50 intravenous 42mg/kg (42mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
mouse LD50 oral 5040mg/kg (5040mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

MUSCULOSKELETAL: OTHER CHANGES
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 25, 1971.
mouse LD50 subcutaneous 2700mg/kg (2700mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

MUSCULOSKELETAL: OTHER CHANGES
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 25, 1971.
rabbit LD50 intravenous 330mg/kg (330mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
rabbit LDLo oral 7gm/kg (7000mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Industrial and Engineering Chemistry. Vol. 15, Pg. 628, 1923.
rat LD50 intraperitoneal 290mg/kg (290mg/kg) ? Toksikologicheskii Vestnik. Vol. (5), Pg. 9, 1994.
rat LD50 oral 3gm/kg (3000mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 561, 1992.
rat LD50 subcutaneous 5500mg/kg (5500mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

MUSCULOSKELETAL: OTHER CHANGES
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 25, 1971.

Sensitive Hygroscopic
Skin, Eye, and Respiratory Irritations Inhalation of dust irritates nose and throat. Contact with eyes causes irritation.
Cleanup Methods Addition of lime will neutralize and precipitate calcium citrate.
Transport UN 1789 8/PG 3
Fire Fighting Procedures /EXTINGUISH WITH/ WATER, FOAM, DRY CHEM, CARBON DIOXIDE.
Fire Potential Combustible liquid
Formulations/Preparations ... Anticoagulant citrate dextrose solution, anticoagulant citrate phosphate dextrose solution, citric acid syrup, & effervescent salts.
Grades of purity: USP; reagent; monohydrate grade.
Grades: Both hydrous (hydrated) and anhydrous, Technical, Chemically Pure, United States Pharmacopeia, Food Chemical Codex.
Citric acid for pharmaceutical use: not 5% water; not >0.05% ash; not >0.001% heavy metals; not > 0.0003% As. Hydrous citric acid may contain up to 8.8% water
Liquid citric acid is commercially available in a variety of concentrations with 50% w/w being most common. Grades are available that vary in appearance, purity, and color.
Exposure Standards and Regulations Substance added directly to human food affirmed as generally recognized as safe (GRAS).
Citric acid used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
Citric acid used as a sequestrant in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.
Drug products containing certain active ingredients offered over-the-counter (OTC) for certain uses. A number of active ingredients have been present in OTC drug products for various uses, as described below. However, based on evidence currently available, there are inadequate data to establish general recognition of the safety and effectiveness of these ingredients for the specified uses: citric acid is included in weight control drug products.
Reactivities and Incompatibilities Pharmaceutical incompatibilities: Potassium tartrate, alkali, and alkaline earth carbonates and bicarbonates, acetates, sulfides.
Potentially explosive reaction with metal nitrates.
Other Preventative Measures SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
Protective Equipment and Clothing Inhalation of dust irritates nose and throat. Contact with eyes causes irritation.
Specification

Citric Acid Anhydrous (CAS NO: 77-92-9) is also called Citric acid anhydrous ; 2-Hydroxy-1,2,3-propanetricarboxylic acid ; 2-Hydroxytricarballylic acid .

Octanol/Water Partition Coefficient log Kow = -1.64
Disposal Methods SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
Inject at base of incinerator equipped with afterburner. Flammable solvent may be added.
 
 
 
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